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Healthy Volunteers: early-phase trial registry
79 of 284 indexed Healthy Volunteers trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #32 of 28,707 conditions by registered trial count.
284 US clinical trials · 79 currently recruiting · #32 of 28,707 conditions by registered trial count
Healthy Volunteers: 284 US clinical trials tracked, 79 recruiting.
Healthy Volunteers is the subject of 284 registered US clinical trials on ClinicalTrials.gov, 79 of them currently open to new participants. 6 are in Phase 3-4 (later-stage) and 206 in Phase 1-2 (earlier-stage). The most active sponsor is Takeda, running 16 of these trials.
Enrollment posture brief
Registry condition healthy-volunteers
OPEN 79 | RECR 28% | LATE 6 | EARLY 206 | RANK #32 | SPON 16
Volume-matched condition peers
Nearest open-share peer: Arrhythmias, Cardiac (28% recruiting · 18 trials)
Healthy Volunteers lists 79 open slots (28% of 284 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Healthy Volunteers on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Healthy Volunteers is recruiting below its size-band peers.
79 of 284 indexed trials (27.8%) are open to enrollment, against a 37.1% average across 139 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Healthy Volunteers trials is spread across many organizations.
Takeda accounts for 16 of 284 trials (5.6%). 144 distinct sponsors appear on at least one study for this condition label.
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Most Healthy Volunteers trials plan to enrol fewer than 100 people.
Median target enrolment is 48 among the 284 trials that report a genuine target (sentinel values excluded). 204 of those (71.8%) plan for fewer than 100 participants.
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Healthy Volunteers research is mostly interventional.
251 interventional and 33 observational studies make up this index (88.4% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
284 total, page 5 of 6
Maribavir Food-Effect Study in Healthy Adults Participants
Takeda
NCT05382104
CYP2B6 Polymorphisms in Ketamine
Washington University School of Medicine
NCT01988922
Effect of Yohimbine on Colon Transit
Mayo Clinic
NCT00217048
Food Effect Study of AG-221 in Healthy Male Subjects
Agios Pharmaceuticals
NCT02218346
A Phase I Study to Compare 3 Different Strengths of an Extended Release Formulation of ASP015K to an Immediate Release Formulation of ASP015K
Astellas Pharma Global Development
NCT01686217
Study to Assess the Intrapulmonary Pharmacokinetics of SPR859 by Comparing the Plasma, Epithelial Lining Fluid (ELF), and Alveolar Macrophages (AM) Concentrations Following the Oral Administration of Five Doses of SPR994 in Healthy, Nonsmoking Volunteers
Spero Therapeutics
NCT04710407
A Study to Assess the Relative Bioavailability and Safety of Different Formulations of AZD4831 in Fasted State in Healthy Volunteers.
AstraZeneca
NCT05457270
A Study to Investigate the Bioequivalence of Two Different Forms of Entrectinib (Forms A and C) Under Fasted Conditions in Healthy Subjects
Genentech
NCT03796013
A Study About How ASP5354 Affects the Body in Healthy Adults and in Adults Whose Kidneys do Not Work Well
Astellas Pharma Global Development
NCT05495581
A Study to Determine the Bioavailability of Vonoprazan Sprinkle Capsules on Pudding or on Applesauce Relative to a Vonoprazan Tablet in Healthy Participants
Phathom Pharmaceuticals
NCT05366738
Study of ITI-214 in Healthy Volunteers to Determine CNS Engagement
Intra-Cellular Therapies
NCT03489772
Phase 1 Study of ALZT-OP1 Combination Therapy in Normal Healthy Volunteers
AZTherapies
NCT02482324
A Study to Compare the Pharmacokinetics and Safety of Mitapivat 100 mg Tablet Formulation With Mitapivat 2 × 50 mg Tablet Formulation in Healthy Adult Participants
Agios Pharmaceuticals
NCT04696393
A Study of TAK-227 in Healthy Adults
Takeda
NCT05818956
A Study to Assess How Food Affects the Safety and Pharmacokinetics of Galicaftor and Navocaftor
AbbVie
NCT05538585
A Study to Assess the Effect Tasimelteon on the Cytochrome P450 3A4 and 2C8 Enzymes in Healthy Subjects
Vanda Pharmaceuticals
NCT01402076
A Study to Evaluate Pharmacokinetic, Safety, Tolerability and Relative Bioavailability of Gepotidacin in Healthy Adult Male and Female Participants
GlaxoSmithKline
NCT05271799
Effect of Venglustat in Patients With Renal Impairment
Genzyme, a Sanofi Company
NCT03687554
A Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of C16TR for Inhalation With Tyvaso® Cohort in Healthy Participants
Insmed Incorporated
NCT06193031
A Study to Assess the Drug Levels of CC-92480 After Coadministration With Rifampin and Itraconazole, and the Drug Levels of Digoxin and Rosuvastatin After Coadministration With CC-92480 in Healthy Participants
Bristol-Myers Squibb
NCT05389722
Food Effect and Bioequivalence Study of Simufilam Tablets in Healthy Volunteers
Cassava Sciences
NCT04932655
A Study of TAK-881 in Healthy Adults
Takeda
NCT05059977
Drug Interaction Study of Multiple Doses of Isavuconazole and a Single Dose of Bupropion
Astellas Pharma Global Development
NCT01635972
Drug Interaction Study of Isavuconazole and Midazolam
Astellas Pharma
NCT01406171
Study in Healthy Volunteers of the Bioavailability of Dexpramipexole Tablets and Food Effects
Knopp Biosciences
NCT01607034
A Study to Understand How the Study Medicine (PF-07081532) is Processed in People With Liver Dysfunction
Pfizer
NCT05478603
A Pilot Study to Compare the Pharmacokinetics (PK) of Single Subcutaneous (SC) Injections of Vedolizumab Administered in Prefilled Syringe (PFS) Versus (vs) Prefilled Syringe in Autoinjector (PFS+AI) in Healthy Participants
Takeda
NCT03961295
Effect Of Hepatic Impairment on the Pharmacokinetics, Safety and Tolerability of PF-06865571 In Subjects With Hepatic Impairment and in Healthy Subjects
Pfizer
NCT04091061
Drug-drug Interaction Study of CTP-543 and Rifampin in Healthy Adult Subjects
Concert Pharmaceuticals
NCT04843540
A Study to Assess Bioequivalence of Fezolinetant Formulations in Healthy Female Participants
Astellas Pharma Global Development
NCT04277624
A Study to Learn About How Food and Esomeprazole Affect the Level of BAY2927088 in the Blood When Taken Together in Healthy Participants
Bayer
NCT06378658
A Study to Assess Potential Interaction Between ASP8062 and Alcohol in Healthy Adult Subjects
Astellas Pharma Global Development
NCT04003402
Effects of Rosuvastatin on the Immune System in Healthy Volunteers With Normal Cholesterol
National Heart, Lung, and Blood Institute (NHLBI)
NCT01200836
Single Oral Dose of 4 mg Cenerimod in Healthy Japanese and Caucasian Subjects
Viatris Innovation
NCT04052360
A Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Repeat Doses of PF-06372865 in Healthy Subjects
Pfizer
NCT03351751
Investigation of Dietary Absorptive Capacity of Fructans in Healthy Subjects - A Dose Response Study
Augusta University
NCT00988403
A Study to Evaluate the Safety, Tolerability, Pharmacodynamics, and Pharmacokinetics (PK) of Oral TAK-994 in an Acute Sleep Phase Delay Paradigm in Healthy Male Participants
Takeda
NCT04551079
Daily Consumption of Well-Cooked Broccoli May Affect Glucosinolate Metabolites and Inflammatory Biomarkers
USDA Beltsville Human Nutrition Research Center
NCT03013465
A Phase 1 Study to Evaluate the Effect of Food on Pharmacokinetics of ASTX029
Astex Pharmaceuticals
NCT04466514
Evaluation of the Relative Bioavailability and Food Effect of GDC-9545 in Healthy Females of Non-Childbearing Potential
Genentech
NCT04274075
Drug Interaction Study Between Raltegravir And UK-453,061
Pfizer
NCT00784420
A Study of RBT-3 in Healthy Volunteers and Volunteers With Stage 3/4 Chronic Kidney Disease
Renibus Therapeutics
NCT04072432
E-cigarette Nicotine Pharmacokinetic Study
British American Tobacco (Investments) Limited
NCT03178981
Tissue Penetration of Ceftolozane/Tazobactam in Diabetic Patients With Lower Limb Infections
Hartford Hospital
NCT02620774
A Study of LY2157299 in Healthy Participants
Eli Lilly and Company
NCT01965808
A Study of Evacetrapib and Digoxin in Healthy Participants
Eli Lilly and Company
NCT01897493
Pediatric Microbiome Study With Children Now Approximately 8-10 Years Old.
Johnson & Johnson Consumer Inc. (J&JCI)
NCT03485755
Effect of Itraconazole on the Pharmacokinetics of Bardoxolone Methyl in Healthy Adults
Biogen
NCT03264079
Metabolic Flexibility as a Biomarker of Adaptation to Diet and Exercise Challenges
USDA Beltsville Human Nutrition Research Center
NCT01987388
A Study to Evaluate the Impact of Omeprazole on the Pharmacokinetics of Sotorasib Co-administered With an Acidic Beverage in Healthy Volunteers
Amgen
NCT05497557
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 198 |
| Phase 2 | 8 |
| Phase 4 | 6 |
Top Sponsors
Named interventions
Most-linked intervention names on Healthy Volunteers records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Healthy Volunteers trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Healthy Volunteers page
284 registered trials, 79 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 79 Healthy Volunteers trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Takeda sponsors the most Healthy Volunteers trials on record, review their full trial history before evaluating a specific study. See Takeda's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Healthy Volunteers condition card totals 284 registered trials; most-linked intervention Placebo; top US site state Maryland. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.