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NCT06729970 · ClinicalTrials.gov registry record · Phase 1
A Study to Evaluate the Effects of Lithium, Valproic Acid, and Lamotrigine on the Pharmacokinetics of KarXT and Effects of KarXT on the Pharmacokinetics of Lithium, Valproic Acid, and Lamotrigine in Healthy Participants
A Phase 1 study of Healthy Volunteers, sponsored by Karuna Therapeutics.
- Completed
- Registry status
- Phase 1
- Development phase
- 133
- Enrollment target
- 1
- Study location
NCT06729970 is a Phase 1 study of Healthy Volunteers that has completed, run by Karuna Therapeutics. The registered enrollment target is 133 participants, below the 481-participant average among 283 other Healthy Volunteers trials with a reported enrollment target (72% lower). The trial reports 1 study location across 1 state.
The verdict
NCT06729970, a Phase 1 study of Healthy Volunteers, has completed, sponsored by Karuna Therapeutics.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 133 participants
- Enrollment target
- 1
- Study location
Study Summary
The purpose of this study is to evaluate the effects of lithium, valproic acid, and lamotrigine on the single-dose pharmacokinetics (PK) of KarXT and the effect of KarXT on the single-dose PK of lithium, valproic acid, and lamotrigine in healthy participants.
Conditions Studied
Interventions
- DRUG Lamotrigine
- DRUG Xanomeline/Trospium Chloride
- DRUG Lithium
- DRUG Valproic Acid
Study Locations (1)
California
- Local Institution - 0001 - Los Alamitos
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 133 participants |
| Start Date | 2024-12-26 |
| Est. Completion | 2026-01-23 |
| Phase | Phase 1 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06729970
The ClinicalTrials.gov registry entry for NCT06729970 describes a study currently listed as completed, categorized as Phase 1. The registered enrollment target is 133 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 481-participant average among 283 other Healthy Volunteers trials with a reported enrollment target (72% lower). The listed sponsor is Karuna Therapeutics, which has 11 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with Healthy Volunteers appearing as the primary indexed condition, and to 4 interventions - of which Lamotrigine is the first listed.
NCT06729970 reports 1 study location spanning 1 distinct geographic area - top geographies include California.
Frequently Asked Questions
What is clinical trial NCT06729970 about?
NCT06729970 is a clinical study titled "A Study to Evaluate the Effects of Lithium, Valproic Acid, and Lamotrigine on the Pharmacokinetics of KarXT and Effects of KarXT on the Pharmacokinetics of Lithium, Valproic Acid, and Lamotrigine in Healthy Participants". The purpose of this study is to evaluate the effects of lithium, valproic acid, and lamotrigine on the single-dose pharmacokinetics (PK) of KarXT and the effect of KarXT on the single-dose PK of lithium, valproic acid, and lamotrigine in healthy participants.
What is the current status of trial NCT06729970?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 133 participants. The study started on 2024-12-26. Estimated completion is 2026-01-23.
What conditions does trial NCT06729970 study?
This clinical trial studies the following conditions: Healthy Volunteers.
What interventions are being tested in trial NCT06729970?
The interventions under investigation include: Lamotrigine (DRUG), Xanomeline/Trospium Chloride (DRUG), Lithium (DRUG), Valproic Acid (DRUG).
Who is sponsoring clinical trial NCT06729970?
This trial is sponsored by Karuna Therapeutics, which has 11 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06729970 being conducted?
This trial has 1 study location across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Read our methodology - how this data is sourced, computed, and verified.
Related
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