Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.

NCT04125459 · ClinicalTrials.gov registry record

Assessing the Role of the NLRP3 Inflammasome in Intercritical Gout

A clinical trial of Gout, sponsored by Attune Health Research.

Active
Registry status
8
Enrollment target
1
Study location

NCT04125459: Active study of Gout, sponsored by Attune Health Research.

NCT04125459 is a study of Gout that is active but no longer recruiting, run by Attune Health Research. The registered enrollment target is 8 participants, below the 8,888-participant average among 34 other Gout trials with a reported enrollment target (100% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.

View on ClinicalTrials.gov ↗

View your shortlist →

The verdict

NCT04125459, a study of Gout, is active but no longer recruiting, sponsored by Attune Health Research.

ACTIVE NOT RECRUITING
Registry status
8 participants
Enrollment target
1
Study location

Study Summary

Gout is an autoinflammatory disease characterized by flares of painful joint inflammation. This inflammation occurs in response to uric acid that crystallizes. After a gout attack, patients usually enter a period that is accompanied by low grade inflammation but is otherwise relatively asymptomatic. Gout is typically associated with certain markers, and this study is going describe specific markers in patients that are in between gout attacks. Research has been focused on studying this phase between gout attacks in hopes to manage and prevent the onset of future gout attacks. Biopsies will be taken from the affected joint and blood will be drawn from patients who are currently in between gout attacks. This work will provide important information regarding how crystals in the joint lining are associated with chronic inflammation in the periods between gout attacks. Moreover, this study will identify novel biomarkers that may be useful in determining the severity of disease activity through a blood test.

Conditions Studied

Gout

Interventions

  • PROCEDURE Joint Biopsy

Study Locations (1)

California

  • Attune Health Research Inc. - Beverly Hills

Trial Details

FieldValue
Enrollment Target 8 participants
Start Date 2020-01-22
Est. Completion 2024-10-03
Attune Health Research

2 total trials

What the registry record for NCT04125459 still lists

NCT04125459 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 8 participants, a relatively small participant target, below the 8,888-participant average among 34 other Gout trials with a reported enrollment target (100% lower).

The record links to 1 condition, with Gout appearing as the primary indexed condition, and to 1 intervention - of which Joint Biopsy is the first listed.

NCT04125459 reports a single indexed study location in California.

Frequently Asked Questions

What is clinical trial NCT04125459 about?

NCT04125459 is a clinical study titled "Assessing the Role of the NLRP3 Inflammasome in Intercritical Gout". Gout is an autoinflammatory disease characterized by flares of painful joint inflammation. This inflammation occurs in response to uric acid that crystallizes. After a gout attack, patients usually enter a period that is accompanied by low grade inflammation but is otherwise relatively asymptomatic....

What is the current status of trial NCT04125459?

This trial is currently active not recruiting. The enrollment target is 8 participants. The study started on 2020-01-22. Estimated completion is 2024-10-03.

What conditions does trial NCT04125459 study?

This clinical trial studies the following conditions: Gout.

What interventions are being tested in trial NCT04125459?

The interventions under investigation include: Joint Biopsy (PROCEDURE).

Who is sponsoring clinical trial NCT04125459?

This trial is sponsored by Attune Health Research, which has 2 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT04125459 being conducted?

This trial has 1 study location across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Learn More About Clinical Trials

Similar trials for Gout

Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.

Where NCT04125459's enrollment target sits among peer trials

8 34th of 34 higher than 1 of 34 other Gout trials

participants (enrollment target), bucketed by value

Each bar is a band; taller bars hold more other Gout trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.

Source ClinicalTrials.gov registry export · 2026-08-08

Nationwide trials with similar profiles

Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.

Similar registry start date

  • NCT05962346 · started 2026-12 · NA

    Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia

  • NCT07125183 · started 2026-12 · Phase 2

    Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma

  • NCT07292298 · started 2026-11 · Phase 2

    Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates

  • NCT04263285 · started 2026-10 · NA

    Treatment of Depression Post-SCI

Related registry views

Source: ClinicalTrials.gov NCT04125459, the US trial registry maintained by the National Library of Medicine. NCT04125459 (small enrollment · single site footprint · active not recruiting) retrieved and formatted by PlainTrial, see methodology.