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Evaluation of Efficacy and Safety of AR882 and XOI Co-administration in Uricase Treatment Failed Patients
NCT07116746 · View on ClinicalTrials.gov ↗
Study Summary
This study will assess the effect of AR882 and XOI co-administration on sUA lowering as well as reducing tophus burden in the population that has failed uricase treatment (eg., pegloticase). Failed uricase treatment is defined as having an inherent intolerance, anaphylaxis, infusion reaction, antibody development, and/or at least one sUA level that rose to greater than 6 mg/dL while on therapy.
Conditions Studied
Interventions
- DRUG AR882 75 mg
- DRUG XOI Low Dose
- DRUG XOI High Dose
Study Locations (8)
Florida
- Arthrosi Investigative Site (105) — Margate
- Arthrosi Investigative Site (102) — Miami
- Arthrosi Investigative Site (109) — Tampa
Mississippi
- Arthrosi Investigative Site (106) — Jackson
North Carolina
- Arthrosi Investigative Site (108) — Charlotte
Pennsylvania
- Arthrosi Investigative Site (103) — Duncansville
Texas
- Arthrosi Investigative Site (104) — West Lake Hills
Washington
- Arthrosi Investigative Site (107) — Bellevue
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 25 participants |
| Start Date | 2025-12-03 |
| Est. Completion | 2027-01 |
| Phase | Phase 2 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT07116746
The ClinicalTrials.gov registry entry for NCT07116746 describes a study currently listed as recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 25 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Arthrosi Therapeutics, which has 5 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 7 conditions, with Gout appearing as the primary indexed condition, and to 3 interventions — of which AR882 75 mg is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT07116746 reports 8 study locations spanning 6 distinct geographic areas — top geographies include Florida, Mississippi, North Carolina. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT07116746 about?
NCT07116746 is a clinical study titled "Evaluation of Efficacy and Safety of AR882 and XOI Co-administration in Uricase Treatment Failed Patients". This study will assess the effect of AR882 and XOI co-administration on sUA lowering as well as reducing tophus burden in the population that has failed uricase treatment (eg., pegloticase). Failed uricase treatment is defined as having an inherent intolerance, anaphylaxis, infusion reaction, antibo...
What is the current status of trial NCT07116746?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 25 participants. The study started on 2025-12-03. Estimated completion is 2027-01.
What conditions does trial NCT07116746 study?
This clinical trial studies the following conditions: Gout, Hyperuricemia, Gout Chronic, Uncontrolled Gout, Gouty Arthritis. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT07116746?
The interventions under investigation include: AR882 75 mg (DRUG), XOI Low Dose (DRUG), XOI High Dose (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT07116746?
This trial is sponsored by Arthrosi Therapeutics, which has 5 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT07116746 being conducted?
This trial has 8 study locations across Florida, Mississippi, North Carolina, Pennsylvania, Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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