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ClinicalTrials.gov 10 recruiting now official registry

Extensive-stage Small-cell Lung Cancer clinical trials

10 of 26 indexed Extensive-stage Small-cell Lung Cancer trials are currently recruiting.

26 US clinical trials · 10 currently recruiting

Extensive-stage Small-cell Lung Cancer is the subject of 26 registered US clinical trials on ClinicalTrials.gov, 10 of them currently open to new participants. 5 are in Phase 3-4 (later-stage) and 20 in Phase 1-2 (earlier-stage). The most active sponsor is Amgen, running 5 of these trials.

The research picture

Extensive-stage Small-cell Lung Cancer has 26 registered US clinical trials, 10 of them open to new participants right now, about 38% of the total.

10
recruiting participants now
38%
of trials open to enrollment
5
in Phase 3–4 (later-stage)
5
top sponsor: Amgen
Phase 17Phase 213Phase 35

Active & Recent Trials

26 total, page 1 of 1

RECRUITING Phase 3 621 participants

Safety and Efficacy of BNT327, an Investigational Therapy in Combination With Chemotherapy for Patients With Untreated Small-cell Lung Cancer

BioNTech SE

NCT06712355

RECRUITING Phase 3 530 participants

A Study to Compare the Efficacy and Safety of BMS-986489 (BMS-986012+ Nivolumab Fixed Dose Combination) in Combination With Carboplatin Plus Etoposide to That of Atezolizumab With Carboplatin Plus Etoposide as First-Line Therapy in Participants With Extensive-Stage Small Cell Lung Cancer (TIGOS).

Bristol-Myers Squibb

NCT06646276

RECRUITING Phase 1 380 participants

A Study of Tarlatamab in Combination With AB248 in Participants With Extensive Stage Small Cell Lung Cancer (DeLLphi-311)

Amgen

NCT07037758

RECRUITING Phase 3 330 participants

A Study Comparing Tarlatamab, Durvalumab, Carboplatin, and Etoposide Versus Durvalumab, Carboplatin, and Etoposide in First-line Extensive Stage Small-Cell Lung Cancer (ES-SCLC)

Amgen

NCT07005128

RECRUITING Phase 1 220 participants

Subcutaneous Tarlatamab in Participants With Extensive Stage Small Cell Lung Cancer (DeLLphi-308)

Amgen

NCT06598306

RECRUITING Phase 1 123 participants

A Study of I-DXd in Combination With Atezolizumab With or Without Carboplatin as First-Line Induction or Maintenance in Subjects With Extensive Stage-Small Cell Lung Cancer (IDeate-Lung03)

Daiichi Sankyo

NCT06362252

RECRUITING Phase 2 49 participants

Durvalumab and Ablative Radiation in Small Cell Lung Cancer (DARES)

University of Chicago

NCT05068232

RECRUITING Phase 2 39 participants

Study of Bevacizumab in Combination With Chemoimmunotherapy and Atezolizumab in Patients With Extensive Stage Small Cell Lung Cancer and Liver Metastases

Kamya Sankar

NCT05588388

RECRUITING Phase 2 30 participants

Chemo-Immunotherapy Followed by Durvalumab and Ceralasertib in Treatment Naïve Patients With Extensive Stage Small Cell Lung Cancer

Muhammad Furqan

NCT04699838

RECRUITING Phase 1 24 participants

A Study of Valemetostat in Combination With Atezolizumab in People With Lung Cancer

Memorial Sloan Kettering Cancer Center

NCT06807632

ACTIVE NOT RECRUITING Phase 3 563 participants

Study Comparing Tarlatamab and Durvalumab Versus Durvalumab Alone in First-Line Extensive-Stage Small-Cell Lung Cancer (ES-SCLC) Following Platinum, Etoposide and Durvalumab

Amgen

NCT06211036

ACTIVE NOT RECRUITING Phase 3 200 participants

To Evaluate Efficacy and Safety of Serplulimab + Chemotherapy (Carboplatin- Etoposide) in US Patients With ES-SCLC

Shanghai Henlius Biotech

NCT05468489

ACTIVE NOT RECRUITING Phase 2 187 participants

Ifinatamab Deruxtecan (I-DXd) in Subjects With Pretreated Extensive-Stage Small Cell Lung Cancer (ES-SCLC)

Daiichi Sankyo

NCT05280470

ACTIVE NOT RECRUITING Phase 1 184 participants

First-Line Tarlatamab in Combination With Carboplatin, Etoposide, and PD-L1 Inhibitor in Subjects With Extensive Stage Small Cell Lung Cancer (ES-SCLC)

Amgen

NCT05361395

ACTIVE NOT RECRUITING Phase 1 141 participants

A Phase 1/2a Study of 23ME-00610 in Patients With Advanced Solid Malignancies

23andMe

NCT05199272

ACTIVE NOT RECRUITING Phase 2 120 participants

A Study of BMS-986012 in Combination With Carboplatin, Etoposide, and Nivolumab as First-line Therapy in Extensive-stage Small Cell Lung Cancer

Bristol-Myers Squibb

NCT04702880

ACTIVE NOT RECRUITING Phase 2 110 participants

Safety, Preliminary Effectiveness of BNT327, an Investigational Therapy for Patients With Small-cell Lung Cancer in Combination With Chemotherapy

BioNTech SE

NCT06449209

ACTIVE NOT RECRUITING Phase 1 24 participants

A Study of [177Lu]Lu-DOTA-TATE in Newly Diagnosed ES-SCLC Patients in Combination With Carboplatin, Etoposide and Atezolizumab

Novartis Pharmaceuticals

NCT05142696

ACTIVE NOT RECRUITING Phase 2 9 participants

MGC018 in Patients With Relapsed or Refractory Extensive-Stage Small-Cell Lung Cancer

Georgetown University

NCT06227546

ACTIVE NOT RECRUITING Phase 2 6 participants

Personalized Neoantigen Vaccine in Combination With Durvalumab (MEDI4736) in Extensive Stage Small Cell Lung Cancer

Washington University School of Medicine

NCT04397003

COMPLETED 272 participants

To Assess the Effectiveness and Safety of Zepzelca in Adult Patients With Extensive Stage Small Cell Lung Cancer (SCLC)

Jazz Pharmaceuticals

NCT04894591

COMPLETED Phase 2 81 participants

A Trial of Amrubicin and Carboplatin With Pegfilgrastim in Patients With Extensive-Stage Small Cell Lung Cancer

SCRI Development Innovations

NCT01076504

COMPLETED Phase 2 72 participants

Cisplatin, Irinotecan, and Bevacizumab, in Treating Patients With Small Cell Lung Cancer

National Cancer Institute (NCI)

NCT00118235

COMPLETED Phase 2 44 participants

Dasatinib in Treating Patients With Relapsed Small Cell Lung Cancer

National Cancer Institute (NCI)

NCT00470054

COMPLETED Phase 2 16 participants

Sunitinib Maintenance Therapy After Induction Platinum-Based Chemotherapy in Patients With ES-SCLC

University of Michigan Rogel Cancer Center

NCT00616109

COMPLETED Phase 2 15 participants

R-(-)-Gossypol Acetic Acid in Treating Patients With Recurrent Extensive-Stage Small Cell Lung Cancer

National Cancer Institute (NCI)

NCT00773955

Phase Distribution

PhaseTrial count
Phase 1 7
Phase 2 13
Phase 3 5

Top Sponsors

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Extensive-stage Small-cell Lung Cancer Trial Landscape

26 indexed Extensive-stage Small-cell Lung Cancer studies · 10 recruiting (38%).

Phase mix: 5 late (III/IV) vs 20 early (I/II).

Top sponsor: Amgen (5 trials), 9 others listed. 26 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Extensive-stage Small-cell Lung Cancer?

PlainTrial tracks 26 US clinical trials for Extensive-stage Small-cell Lung Cancer, of which 10 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Extensive-stage Small-cell Lung Cancer?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.