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RECRUITING Phase 1

A Study of Tarlatamab in Combination With AB248 in Participants With Extensive Stage Small Cell Lung Cancer (DeLLphi-311)

NCT07037758 · View on ClinicalTrials.gov ↗

Study Summary

The primary objective for dose exploration and dose expansion is to evaluate the safety and tolerability of tarlatamab in combination with AB248. The primary objective for dose exploration only is to determine the recommended dose for expansion and/or maximum tolerated combination dose (MTCD) of AB248 in combination with tarlatamab.

Interventions

  • DRUG Tarlatamab
  • DRUG AB248

Study Locations (17)

Other

  • Chungbuk National University Hospital — Cheongju Chungbuk
  • Seoul National University Bundang Hospital — Seongnam-si, Gyeonggi-do
  • Severance Hospital Yonsei University Health System — Seoul
  • Adana Sehir Egitim ve Arastirma Hastanesi — Adana
  • Hacettepe Universitesi Tip Fakultesi Hastanesi — Ankara
  • Ankara Bilkent Sehir Hastanesi — Ankara

Pennsylvania

  • Sidney Kimmel Cancer Center — Philadelphia
  • Allegheny General Hospital — Pittsburgh

California

  • University of Southern California, Norris Comprehensive Cancer Center — Los Angeles

Florida

  • Moffitt Cancer Center — Tampa

Georgia

  • Emory University — Atlanta

Kentucky

  • Norton Cancer Institute - Downtown — Louisville

Massachusetts

  • Dana-Farber Cancer Institute — Boston

Missouri

  • Siteman Cancer Center — St Louis

Trial Details

FieldValue
Enrollment Target 380 participants
Start Date 2025-09-16
Est. Completion 2031-01-18
Phase Phase 1

Sponsor

Amgen

266 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT07037758

The ClinicalTrials.gov registry entry for NCT07037758 describes a study currently listed as recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 380 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Amgen, which has 266 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Extensive Stage Small Cell Lung Cancer appearing as the primary indexed condition, and to 2 interventions — of which Tarlatamab is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT07037758 reports 17 study locations spanning 11 distinct geographic areas — top geographies include Other, Pennsylvania, California. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT07037758 about?

NCT07037758 is a clinical study titled "A Study of Tarlatamab in Combination With AB248 in Participants With Extensive Stage Small Cell Lung Cancer (DeLLphi-311)". The primary objective for dose exploration and dose expansion is to evaluate the safety and tolerability of tarlatamab in combination with AB248. The primary objective for dose exploration only is to determine the recommended dose for expansion and/or maximum tolerated combination dose (MTCD) of AB...

What is the current status of trial NCT07037758?

This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 380 participants. The study started on 2025-09-16. Estimated completion is 2031-01-18.

What conditions does trial NCT07037758 study?

This clinical trial studies the following conditions: Extensive Stage Small Cell Lung Cancer. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT07037758?

The interventions under investigation include: Tarlatamab (DRUG), AB248 (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT07037758?

This trial is sponsored by Amgen, which has 266 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT07037758 being conducted?

This trial has 17 study locations across California, Florida, Georgia, Kentucky, Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial