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NCT06646276 · ClinicalTrials.gov registry record · Phase 3
A Study to Compare the Efficacy and Safety of BMS-986489 (BMS-986012+ Nivolumab Fixed Dose Combination) in Combination With Carboplatin Plus Etoposide to That of Atezolizumab With Carboplatin Plus Etoposide as First-Line Therapy in Participants With Extensive-Stage Small Cell Lung Cancer (TIGOS).
A Phase 3 study of Extensive-stage Small-cell Lung Cancer, sponsored by Bristol-Myers Squibb.
- Recruiting
- Registry status
- Phase 3
- Development phase
- 530
- Enrollment target
- 20
- Study locations
NCT06646276: Recruiting Phase 3 study of Extensive-stage Small-cell Lung Cancer, sponsored by Bristol-Myers Squibb.
NCT06646276 is a Phase 3 study of Extensive-stage Small-cell Lung Cancer that is actively recruiting participants, run by Bristol-Myers Squibb. The registered enrollment target is 530 participants, above the 154-participant average among 25 other Extensive-stage Small-cell Lung Cancer trials with a reported enrollment target (244% higher). The trial reports 20 study locations across 15 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06646276, a Phase 3 study of Extensive-stage Small-cell Lung Cancer, is actively recruiting participants, sponsored by Bristol-Myers Squibb.
- RECRUITING
- Registry status
- Phase 3
- Development phase
- 530 participants
- Enrollment target
- 20
- Study locations
Study Summary
The Purpose of the Study is to Compare the Efficacy and Safety of BMS-986489 (Anti-fucosyl-GM1+ Nivolumab Fixed Dose Combination) in Combination with Carboplatin plus Etoposide to that of Atezolizumab with Carboplatin plus Etoposide as First-Line Therapy in Participants with Extensive-Stage Small Cell Lung Cancer.
Conditions Studied
Interventions
- DRUG Carboplatin
- BIOLOGICAL Atezolizumab
- DRUG Etoposide
- BIOLOGICAL BMS-986489 (BMS-986012+Nivolumab)
Study Locations (20)
Florida
- Florida Cancer Specialists - South - Fort Myers
- Mid Florida Hematology and Oncology Center - Orange City
- Florida Cancer Specialists - North - St. Petersburg
North Dakota
- Local Institution - 0232 - Bismarck
- Local Institution - 0010 - Fargo
Texas
- Texas Oncology - Central/South Texas - Austin
- Texas Oncology - Northeast Texas - Tyler
Washington
- Swedish Cancer Institute - Edmonds - Edmonds
- Swedish Medical Center - Seattle
Alabama
- Southern Cancer Center, PC - Daphne
Arkansas
- Local Institution - 0283 - Hot Springs
Georgia
- Northwest Georgia Oncology Centers, a Service of Wellstar Cobb Hospital - Marietta
Illinois
- Illinois Cancer Care - Peoria
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 530 participants |
| Start Date | 2025-02-25 |
| Est. Completion | 2031-09-05 |
| Phase | Phase 3 |
What NCT06646276 shows while recruiting
NCT06646276 is an interventional study that assigns participants to a tested intervention. The registered 530 participants enrollment target is mid-sized for trials with a published cap, above the 154-participant average among 25 other Extensive-stage Small-cell Lung Cancer trials with a reported enrollment target (244% higher).
The record links to 1 condition, with Extensive-stage Small-cell Lung Cancer appearing as the primary indexed condition, and to 4 interventions - of which Carboplatin is the first listed.
NCT06646276 names 20 study sites across 15 states, led by Florida, North Dakota, Texas.
Frequently Asked Questions
What is clinical trial NCT06646276 about?
NCT06646276 is a clinical study titled "A Study to Compare the Efficacy and Safety of BMS-986489 (BMS-986012+ Nivolumab Fixed Dose Combination) in Combination With Carboplatin Plus Etoposide to That of Atezolizumab With Carboplatin Plus Etoposide as First-Line Therapy in Participants With Extensive-Stage Small Cell Lung Cancer (TIGOS).". The Purpose of the Study is to Compare the Efficacy and Safety of BMS-986489 (Anti-fucosyl-GM1+ Nivolumab Fixed Dose Combination) in Combination with Carboplatin plus Etoposide to that of Atezolizumab with Carboplatin plus Etoposide as First-Line Therapy in Participants with Extensive-Stage Small Ce...
What is the current status of trial NCT06646276?
This trial is currently recruiting. It is a Phase 3 study. The enrollment target is 530 participants. The study started on 2025-02-25. Estimated completion is 2031-09-05.
What conditions does trial NCT06646276 study?
This clinical trial studies the following conditions: Extensive-stage Small-cell Lung Cancer.
What interventions are being tested in trial NCT06646276?
The interventions under investigation include: Carboplatin (DRUG), Atezolizumab (BIOLOGICAL), Etoposide (DRUG), BMS-986489 (BMS-986012+Nivolumab) (BIOLOGICAL).
Who is sponsoring clinical trial NCT06646276?
This trial is sponsored by Bristol-Myers Squibb, which has 1,025 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06646276 being conducted?
This trial has 20 study locations across Alabama, Arkansas, Florida, Georgia, Illinois. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT06646276's enrollment target sits among peer trials
530 3rd of 25 higher than 23 of 25 other Extensive-stage Small-cell Lung Cancer trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Extensive-stage Small-cell Lung Cancer trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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