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ClinicalTrials.gov 25 recruiting now official registry

End Stage Renal Disease clinical trials

25 of 88 indexed End Stage Renal Disease trials are currently recruiting.

88 US clinical trials · 25 currently recruiting

End Stage Renal Disease is the subject of 88 registered US clinical trials on ClinicalTrials.gov, 25 of them currently open to new participants. 16 are in Phase 3-4 (later-stage) and 27 in Phase 1-2 (earlier-stage). The most active sponsor is Vanderbilt University, running 4 of these trials.

The research picture

End Stage Renal Disease has 88 registered US clinical trials, 25 of them open to new participants right now, about 28% of the total.

25
recruiting participants now
28%
of trials open to enrollment
16
in Phase 3–4 (later-stage)
4
top sponsor: Vanderbilt University
Phase 113Phase 214Phase 37Phase 49

Active & Recent Trials

88 total, page 2 of 2

COMPLETED NA 103 participants

Percutaneous Less Invasive AV Fistula for Vascular Access in ESRD

Medtronic Endovascular

NCT02363972

COMPLETED Phase 3 100 participants

An Evaluation of IV Gamma Globulin As a Method to Improve Kidney Transplant Survival in Patients With End-Stage Renal Disease Who Are Highly Sensitized to Transplant Antigens

National Institute of Allergy and Infectious Diseases (NIAID)

NCT00000935

COMPLETED Phase 2 99 participants

Safety Trial of Single Versus Multiple Dose Thymoglobulin Induction in Kidney Transplantation

Wright State University

NCT00906204

COMPLETED NA 97 participants

Specialized Community Disease Management to Reduce Substance Use and Hospital Readmissions

Treatment Research Institute

NCT02059005

COMPLETED Phase 2 88 participants

Pharmacodynamic Study of AZD1722 in End-stage Renal Disease Patients on Hemodialysis

Ardelyx

NCT01764854

COMPLETED Phase 3 75 participants

A Study to Evaluate the Safety and Efficacy of Paricalcitol Capsules in Reducing Serum Intact Parathyroid Hormone Levels in End Stage Renal Disease Subjects on Peritoneal Dialysis

Abbott

NCT00646035

COMPLETED Phase 1 70 participants

C1INH Inhibitor Preoperative and Post Kidney Transplant to Prevent DGF & IRI

Cedars-Sinai Medical Center

NCT02134314

COMPLETED NA 67 participants

End-Stage Renal Disease Intra-dialysis Lifestyle Education Study

Vanderbilt University Medical Center

NCT02361268

COMPLETED 64 participants

A Study Evaluating the Association of Inflammation With Hemodialysis Access Type

Montefiore Medical Center

NCT01011985

COMPLETED Phase 1 58 participants

Effects of Hemodialysis on the Sleep/Wake Cycle

Emory University

NCT00460863

COMPLETED NA 58 participants

Comparison of Nocturnal Hemodialysis (NHD) and Short Daily Hemodialysis (DHD) With the NxStage® System One™

NxStage Medical

NCT00667511

COMPLETED NA 47 participants

Effects of Oral Cholecalciferol (Vitamin D3) on Bone Health, Neuromuscular Function, and Quality of Life in Adults With Chronic Kidney Disease

Creighton University

NCT00511225

COMPLETED Phase 1 45 participants

A Study to Evaluate the Effect of Renal Function on the Biological Activity of Telavancin

Cumberland Pharmaceuticals

NCT01238796

COMPLETED Phase 1 41 participants

Use of Immune Globulin Plus Rituximab for Desensitization in Highly HLA Sensitized Patients Awaiting Deceased Donor Kidney Transplantation

Stanley Jordan, MD

NCT01178216

COMPLETED Phase 4 38 participants

Thymoglobulin Versus Alemtuzumab Versus Daclizumab in Living Donor Renal Transplantation

University of Miami

NCT01046955

COMPLETED Phase 4 36 participants

Patiromer Efficacy to Reduce Episodic Hyperkalemia in End Stage Renal Disease Patients

Duke University

NCT03781089

COMPLETED 33 participants

A Comparison of Physical Activity Levels With and Without Feedback Via Fitbit® Flex™ in Hemodialysis Patients

Renal Research Institute

NCT02320513

COMPLETED NA 31 participants

Inflammation, Proteolysis and IL-1 Beta Receptor Inhibition in Chronic Hemodialysis Patients

Vanderbilt University

NCT00420290

COMPLETED Phase 2 26 participants

The Effects of Protein Supplementation and Resistance Exercise in Hemodialysis Patients

Vanderbilt University

NCT00179140

COMPLETED Phase 1 23 participants

Study to Investigate the Pharmacokinetic Comparability of Dosing Triferic AVNU IV by Continuous Infusion and IV Bolus.

Rockwell Medical Technologies

NCT04409132

COMPLETED 20 participants

CellCept/Iron Study: The Iron Ion-Mycophenolate Mofetil Chelation Complex Interaction in Renal Allograft Recipients

University of Michigan

NCT00227045

COMPLETED Phase 2 19 participants

The Effects of Resistance Exercise and Protein Supplementation in Hemodialysis Patients

Vanderbilt University

NCT00179218

COMPLETED NA 16 participants

Treatment Modification to Reduce Symptom Burden in Hemodialysis

The Rogosin Institute

NCT01775800

COMPLETED Phase 1 16 participants

Study to Evaluate Daptomycin Given During Dialysis and After Dialysis

Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)

NCT00882557

COMPLETED Phase 2 12 participants

Safety and Dose Finding Study of Xigris in Hemodialysis Patients

George Washington University

NCT01227187

COMPLETED NA 12 participants

First Evaluation of the Moda-Flx Hemodialysis System™ in Real World Clinical Settings

Diality

NCT06581393

COMPLETED Phase 4 12 participants

Triferic AVNU Infusion Via Freedom Pump During Hemodialysis

Rockwell Medical Technologies

NCT04689932

COMPLETED NA 11 participants

Acid-Base Composition With Use of hemoDialysates

Fresenius Medical Care North America

NCT02334267

COMPLETED Phase 2 11 participants

The Effects of Nutrition Supplementation and Resistance Exercise During Hemodialysis

Vanderbilt University

NCT00179179

COMPLETED Phase 1 10 participants

Trial of Adoptive Immunotherapy With TRACT to Prevent Rejection in Living Donor Kidney Transplant Recipients

Northwestern University

NCT02145325

COMPLETED Early Phase 1 9 participants

A Pilot Study Using Autologous Regulatory T Cell Infusion Zortress (Everolimus) in Renal Transplant Recipients

Roberto Gedaly

NCT03284242

COMPLETED NA 8 participants

A Plant Based High Protein Diet to Improve Nutritional Outcomes in Peritoneal Dialysis Patients

Ochsner Health System

NCT02360748

COMPLETED Phase 4 8 participants

Effect of Dialysis on the Pharmacokinetics of Telavancin in Patients With Chronic Kidney Disease Stage 5

University of Michigan

NCT02392208

COMPLETED Phase 4 7 participants

Ertapenem Pharmacokinetics in Patients in Continuous Ambulatory Peritoneal Dialysis

Albany College of Pharmacy and Health Sciences

NCT00939952

COMPLETED Phase 2 7 participants

Pharmacokinetics and Optimal Dose of Ertapenem in Hemodialysis Patients

Corewell Health East

NCT02159859

COMPLETED Phase 1 6 participants

Plazomicin Study in ESRD Patients Receiving IHD

Cipla USA

NCT04699656

COMPLETED Phase 2 1 participants

Eculizumab to Enable Renal Transplantation in Patients With History of Catastrophic Antiphospholipid Antibody Syndrome

Johns Hopkins University

NCT01029587

COMPLETED Phase 3

Prevention of Kidney Transplant Rejection

National Institute of Allergy and Infectious Diseases (NIAID)

NCT00005010

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Phase Distribution

PhaseTrial count
Phase 1 13
Phase 2 14
Phase 3 7
Phase 4 9

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the End Stage Renal Disease Trial Landscape

88 indexed End Stage Renal Disease studies · 25 recruiting (28%).

Phase mix: 16 late (III/IV) vs 27 early (I/II).

Top sponsor: Vanderbilt University (4 trials), 9 others listed. 38 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for End Stage Renal Disease?

PlainTrial tracks 88 US clinical trials for End Stage Renal Disease, of which 25 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for End Stage Renal Disease?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.