Ardelyx

25 total trials 3 currently recruiting 21 completed

Ardelyx sponsors 25 registered US clinical trials on ClinicalTrials.gov, 3 of them currently recruiting, and 21 completed. 9 of these trials are in Phase 3-4 (later-stage) and 16 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Irritable Bowel Syndrome With Constipation (IBS-C), with 2 trials.

Trial Pipeline

25 total, page 1 of 1

RECRUITING Phase 3

A 26-Wk Study to Assess Safety & Efficacy of Tenapanor for T/t of Chronic Idiopathic Constipation in Adults

NCT07382167

RECRUITING Phase 2

4-Week, Multi-center Dose-Ranging Study for the IBS-C in Pts. 6 to <12 Yrs

NCT06553547

RECRUITING Phase 3

Study to Assess Safety and Efficacy of Tenapanor for Treatment of IBS-C in Pediatric Patients 12 to Less Than 18 Years

NCT05643534

COMPLETED Phase 1

An Open-label Study to Evaluate the Pharmacokinetics of Oral Tenapanor in Breast Milk of Lactating Females

NCT06203444

COMPLETED Phase 2

A Study Evaluating the Safety and Efficacy of RDX013 for the Treatment of Hyperkalemia

NCT04780841

COMPLETED Phase 4

Study to Evaluate the Use of Tenapanor as Core Therapy in the Treatment of Hyperphosphatemia

NCT04549597

COMPLETED Phase 4

A Long-Term Study of Tenapanor Alone or in Combination With Sevelamer in Patients With CKD on Dialysis and HP

NCT03988920

COMPLETED Phase 2

Study to Evaluate the Efficacy of Tenapanor as Adjunctive Therapy to Phosphate Binder Therapy

NCT03824587

COMPLETED Phase 3

A Phase 3 Study of Tenapanor to Treat Hyperphosphatemia in ESRD Patients on Dialysis

NCT03427125

TERMINATED Phase 2

A Study Evaluating the Onset-of-Action, Safety, and Efficacy of RDX227675 for the Treatment of Hyperkalemia

NCT03018067

COMPLETED Phase 3

A Long-Term Safety Study of Tenapanor for the Treatment of IBS-C

NCT02727751

COMPLETED Phase 3

An 8-Week Study to Evaluate Tenapanor in the Treatment of Hyperphosphatemia in End-Stage Renal Disease Patients on Hemodialysis (ESRD-HD)

NCT02675998

COMPLETED Phase 3

A 26-Week Study to Evaluate the Efficacy and Safety of Tenapanor in IBS-C

NCT02686138

COMPLETED Phase 3

A 12-Week Study With a 4-Week Randomized Withdrawal Period to Evaluate the Efficacy and Safety of Tenapanor for the Treatment of IBS-C

NCT02621892

COMPLETED Phase 1

To Evaluate the Effect of AZD1722 on the Pharmacokinetics of Oral Midazolam in Healthy Volunteers

NCT02140268

COMPLETED Phase 1

To Assess the Effect of AZD1722 on the Pharmacokinetics of Cefadroxil in Healthy Volunteers

NCT02140281

COMPLETED Phase 2

Dose Finding Study to Treat High Phosphate Levels in the Blood.

NCT02081534

COMPLETED Phase 2

The Efficacy of AZD1722 in Constipation Predominant Irritable Bowel Syndrome (IBS-C)

NCT01923428

COMPLETED Phase 1

Safety, Tolerability, Pharmacokinetics and Pharmacodynamic of AZD1722 in Healthy Male and Female Japanese Subjects

NCT02176252

COMPLETED Phase 2

A Study in CKD Patients With Type 2 Diabetes Mellitus and Albuminuria

NCT01847092

COMPLETED Phase 1

A Phase 1 Study to Examine the Effect of Renvela on the Pharmacodynamics of AZD1722

NCT02346890

COMPLETED Phase 1

D5611C00003 - Food Interaction Study With AZD1722 Tablet in Healthy Subjects

NCT02226783

COMPLETED Phase 1

A Phase 1 Study to Examine the Pharmacodynamics of Different AZD1722 Formulations

NCT02249936

COMPLETED Phase 2

Pharmacodynamic Study of AZD1722 in End-stage Renal Disease Patients on Hemodialysis

NCT01764854

COMPLETED Phase 2

A Study to Evaluate the Safety and Efficacy of RDX5791 for the Treatment of Constipation Predominant Irritable Bowel Syndrome (IBS-C)

NCT01340053

What the Pipeline for Ardelyx Shows

According to the ClinicalTrials.gov registry, Ardelyx is linked to 25 US clinical trials across every stage of research activity. Of those, 3 studies are currently recruiting, about 12% of the sponsor's indexed portfolio, and 21 are already marked complete, representing roughly 84% of the total.

The phase mix for Ardelyx reports 9 late-stage studies (Phase 3 and Phase 4 combined) and 16 earlier-phase studies (Phase 1 and Phase 2).

The top therapeutic focus area indexed for Ardelyx is Irritable Bowel Syndrome With Constipation (IBS-C) with 2 linked trials, and 8 other condition areas appear in the top list above.

How to read these pipeline numbers

Recruiting share is one of the more practical signals here: it reflects how much of a sponsor's research is presently open to new participants, while the completed share indicates the depth of finished work that has already contributed registry results. Both counts come directly from the public ClinicalTrials.gov dataset and are refreshed on the registry side; this page mirrors the latest data pull without altering it.

A portfolio weighted toward Phase 3 usually reflects an organization advancing candidates toward regulatory review, where the research centers on comparative efficacy and broader safety across larger populations. A heavier Phase 1 and Phase 2 tilt generally indicates exploratory work, safety, dosing, and early signal detection, and is common among research-forward sponsors that seed many early programs. Phase 4 entries, when present, track interventions already in real-world use and typically focus on long-term safety, effectiveness across subgroups, or formulation comparisons.

That distribution is a quick read of where the organization concentrates its research attention; it does not imply product availability, market share, or any clinical endorsement. All numbers on this page come from ClinicalTrials.gov maintained by the National Library of Medicine, and counts can shift as new studies are registered or existing ones update their status. This information is provided for reference and educational purposes only, not as medical, investment, or regulatory advice, verify current details directly with ClinicalTrials.gov before relying on any figure here.

Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial from this sponsor, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.