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CSP #2026 - Beta Blocker Dialyzability on Cardiovascular Outcomes
NCT05931276 · View on ClinicalTrials.gov ↗
Study Summary
The investigators aim to determine, using a point-of-care randomized controlled trial design, if hemodialysis patients, who are randomized to metoprolol succinate (a dialyzable, beta-1 selective beta blocker), have an improved cardiovascular outcome compared to those randomized to carvedilol (a non-dialyzable, non-selective beta blocker with alpha-1 antagonist properties). The investigators will also examine intervention practices to identify components that best support engagement and sustainability.
Conditions Studied
Interventions
- DRUG Metoprolol Succinate
- DRUG Carvedilol
Study Locations (8)
California
- VA Long Beach Healthcare System, Long Beach, CA — Long Beach
Florida
- North Florida/South Georgia Veterans Health System, Gainesville, FL — Gainesville
Georgia
- Atlanta VA Medical and Rehab Center, Decatur, GA — Decatur
Iowa
- Iowa City VA Health Care System, Iowa City, IA — Iowa City
Massachusetts
- VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA — Boston
Minnesota
- Minneapolis VA Health Care System, Minneapolis, MN — Minneapolis
Nebraska
- Omaha VA Nebraska-Western Iowa Health Care System, Omaha, NE — Omaha
New Mexico
- New Mexico VA Health Care System, Albuquerque, NM — Albuquerque
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 2,540 participants |
| Start Date | 2024-05-22 |
| Est. Completion | 2028-12-31 |
| Phase | Phase 3 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05931276
The ClinicalTrials.gov registry entry for NCT05931276 describes a study currently listed as recruiting. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 2,540 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is VA Office of Research and Development, which has 1,863 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 2 conditions, with End-Stage Renal Disease appearing as the primary indexed condition, and to 2 interventions — of which Metoprolol Succinate is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT05931276 reports 8 study locations spanning 8 distinct geographic areas — top geographies include California, Florida, Georgia. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT05931276 about?
NCT05931276 is a clinical study titled "CSP #2026 - Beta Blocker Dialyzability on Cardiovascular Outcomes". The investigators aim to determine, using a point-of-care randomized controlled trial design, if hemodialysis patients, who are randomized to metoprolol succinate (a dialyzable, beta-1 selective beta blocker), have an improved cardiovascular outcome compared to those randomized to carvedilol (a non-...
What is the current status of trial NCT05931276?
This trial is currently recruiting. It is a Phase 3 study. The enrollment target is 2,540 participants. The study started on 2024-05-22. Estimated completion is 2028-12-31.
What conditions does trial NCT05931276 study?
This clinical trial studies the following conditions: End-Stage Renal Disease, End-Stage Kidney Disease. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT05931276?
The interventions under investigation include: Metoprolol Succinate (DRUG), Carvedilol (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT05931276?
This trial is sponsored by VA Office of Research and Development, which has 1,863 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT05931276 being conducted?
This trial has 8 study locations across California, Florida, Georgia, Iowa, Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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