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Diabetes Mellitus, Type 2 clinical trials
63 of 351 indexed Diabetes Mellitus, Type 2 trials are currently recruiting.
351 US clinical trials · 63 currently recruiting
Diabetes Mellitus, Type 2 is the subject of 351 registered US clinical trials on ClinicalTrials.gov, 63 of them currently open to new participants. 100 are in Phase 3-4 (later-stage) and 80 in Phase 1-2 (earlier-stage). The most active sponsor is Novo Nordisk A/S, running 48 of these trials.
The research picture
Diabetes Mellitus, Type 2 has 351 registered US clinical trials, 63 of them open to new participants right now, about 18% of the total.
- 63
- recruiting participants now
- 18%
- of trials open to enrollment
- 100
- in Phase 3–4 (later-stage)
- 48
- top sponsor: Novo Nordisk A/S
Active & Recent Trials
351 total, page 4 of 8
Diabetes Coaching Program for Medicare Advantage Members With Type 2 Diabetes - Impact on A1c
Evidation Health
NCT03363100
Impact of Dietary Intervention on Weight Change in Subjects With Type 2 Diabetes
Novo Nordisk A/S
NCT01232491
Project MiNT: Assessing the Impact of Food & Video-Based Nutrition Education on Patients With Poorly Controlled Diabetes
Thomas Jefferson University
NCT04264572
Vildagliptin Compared to Pioglitazone in Combination With Metformin in Patients With Type 2 Diabetes
Novartis
NCT00237237
A Research Study to Compare Two Types of Insulin, a New Insulin, Insulin Icodec and an Available Insulin, Insulin Degludec, in People With Type 2 Diabetes Who Have Not Used Insulin Before (ONWARDS 3)
Novo Nordisk A/S
NCT04795531
Gan & Lee Insulin Glargine Target Type (2) Evaluating Research
Gan and Lee Pharmaceuticals, U
NCT03371108
Comparative Effectiveness of Family DSMES and Standard DSMES Among Diverse Populations
University of Arkansas
NCT04334109
Efficacy and Safety of Vildagliptin in Combination With Metformin in Patients With Type 2 Diabetes
Novartis Pharmaceuticals
NCT00099892
Understanding and Improving Diabetes Care for Ethnic Minorities
University of California, Irvine
NCT01123239
Evaluation of Insulin Glargine Versus Sitagliptin in Insulin-naive Patients
Sanofi
NCT00751114
NovoLog Observation Trial in Subjects With Type 1 and Type 2 Diabetes
Novo Nordisk A/S
NCT00095446
A Research Study to See How Semaglutide Helps People With Excess Weight and Type 2 Diabetes Lose Weight
Novo Nordisk A/S
NCT05649137
A Safety and Efficacy Study Comparing Naltrexone SR/Bupropion SR and Placebo in Obese Subjects With Type 2 Diabetes
Orexigen Therapeutics
NCT00474630
Comparison of Insulin Detemir Morning, Insulin Detemir Evening and NPH Insulin Evening in Patients With Type 2 Diabetes
Novo Nordisk A/S
NCT00104182
A Study of LY2963016 Compared to LANTUS® in Adult Participants With Type 2 Diabetes Mellitus
Eli Lilly and Company
NCT02302716
GLP-1 Receptor Agonist Lixisenatide in Patients With Type 2 Diabetes for Glycemic Control and Safety Evaluation, on Top of Metformin
Sanofi
NCT00763451
Comparison of Two Basal Insulins for Patients With Type 2 Diabetes on Anti-Hyperglycemic Medications (IOPE)
Eli Lilly and Company
NCT00510952
Comparison of NN1250 With Insulin Glargine in Subjects With Type 2 Diabetes
Novo Nordisk A/S
NCT01076647
Comparison of NN5401 With Insulin Glargine, Both in Combination With Oral Antidiabetic Drugs, in Subjects With Type 2 Diabetes
Novo Nordisk A/S
NCT01045447
Comparison of NN1250 With Sitagliptin in Subjects With Type 2 Diabetes Never Treated With Insulin
Novo Nordisk A/S
NCT01046110
The Efficacy of Insulin Degludec/Liraglutide as add-on Therapy in Controlling Glycaemia in Adults With Type 2 Diabetes Inadequately Controlled on Sulphonylurea With or Without Metformin Therapy
Novo Nordisk A/S
NCT01618162
Comparison of TAK-875 (Fasiglifam) With Placebo in Participants With Type 2 Diabetes
Takeda
NCT01456195
A Study to Compare a New Drug for Type 2 Diabetes to Placebo and to a Treatment Already Available for Type 2 Diabetes
OPKO Health
NCT02119819
Home Food Delivery for Diabetes Management in Patients of Rural Clinics
University of Arkansas
NCT04876053
A Study to Evaluate the Effect of ASP1941 in Adult Patients With Type 2 Diabetes Mellitus
Astellas Pharma
NCT01071850
Evaluation of Glucose Lowering Effect, Safety and Tolerability of CS-917
Daiichi Sankyo
NCT00290940
Diabetes Prevention Program Lifestyle Intervention in the Marshallese Population
University of Arkansas
NCT03270436
Compare Two Dosing Algorithms in Insulin-Naive Patients With Type 2 Diabetes Mellitus
Eli Lilly and Company
NCT00391209
Comparison of Two Insulin Degludec Formulations in Subjects With Type 2 Diabetes Mellitus
Novo Nordisk A/S
NCT01364428
A Study of Taspoglutide Versus Placebo for the Treatment of Patients With Type 2 Diabetes Mellitus Inadequately Controlled With Diet and Exercise.
Hoffmann-La Roche
NCT00744926
Mitiglinide in Combination With Metformin vs. Metformin Alone in Patients With Type 2 Diabetes Mellitus
Elixir Pharmaceuticals
NCT00519142
English Diabetes Self-Management Program
Stanford University
NCT00684086
The Effect of Insulin Degludec in Combination With Liraglutide and Metformin in Subjects With Type 2 Diabetes Qualifying for Treatment Intensification
Novo Nordisk A/S
NCT01664247
Comparison of Two Basal Insulins for Patients With Type 2 Diabetes Taking Oral Diabetes Medicines and Exenatide
Eli Lilly and Company
NCT00560417
Efficacy and Long-Term Safety of Vildagliptin as Monotherapy in Patients With Type 2 Diabetes
Novartis
NCT00821977
Dose-Ranging Study in Treatment Naive Type 2 Diabetes Mellitus(T2DM)
GlaxoSmithKline
NCT00500331
An Online System to Improve Diabetes Self-Care
Robert Wood Johnson Foundation
NCT00119938
OpT2mise Glucose Control in Type 2 Diabetes Mellitus (DM) With Insulin Pump Therapy
Medtronic Diabetes
NCT01182493
A Study of Taspoglutide Versus Placebo for the Treatment of Patients With Type 2 Diabetes Mellitus Inadequately Controlled With Metformin Plus Pioglitazone.
Hoffmann-La Roche
NCT00744367
Long-Term Effects of Insulin Plus Metformin Regimens on the Overall and Postprandial Glycemic Control of Patients With Type 2 Diabetes
Eli Lilly and Company
NCT00191464
Afrezza® INHALE-1 Study in Pediatrics
Mannkind Corporation
NCT04974528
Linagliptin and Metformin Versus Linagliptin in Newly Diagnosed, Untreated Type 2 Diabetes
Boehringer Ingelheim
NCT01512979
Dulce Digital-Me: An Adaptive mHealth Intervention for Underserved Hispanics With Diabetes
Scripps Whittier Diabetes Institute
NCT03130699
Efficacy and Safety of Semaglutide Once-weekly Versus Placebo as add-on to SGLT-2i in Subjects With Type 2 Diabetes Mellitus
Novo Nordisk A/S
NCT03086330
Improving Physical Activity Through a mHealth Intervention in Cardio-metabolic Risk Patients
Massachusetts General Hospital
NCT02551640
Understanding of Genetic Risk Information for Type 2 Diabetes
Duke University
NCT01186354
Comparison of Biphasic Insulin Aspart 70/30 Versus Insulin Glargine in Subjects With Type 2 Diabetes
Novo Nordisk A/S
NCT00097877
A Study of DPP-IV Inhibitor in Patients With Type 2 Diabetes
Hoffmann-La Roche
NCT00111670
Linagliptin Versus Placebo in Type 2 Diabetic Patients With Inadequate Glycaemic Control on Metformin in Combination With Pioglitazone
Boehringer Ingelheim
NCT00996658
Post Approval Study of the Eversense® Continuous Glucose Monitoring
Senseonics
NCT03908125
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 42 |
| Phase 2 | 38 |
| Phase 3 | 74 |
| Phase 4 | 26 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Diabetes Mellitus, Type 2 Trial Landscape
351 indexed Diabetes Mellitus, Type 2 studies · 63 recruiting (18%).
Phase mix: 100 late (III/IV) vs 80 early (I/II).
Top sponsor: Novo Nordisk A/S (48 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Diabetes Mellitus, Type 2?
PlainTrial tracks 351 US clinical trials for Diabetes Mellitus, Type 2, of which 63 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Diabetes Mellitus, Type 2?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.