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COMPLETED Phase 3

A Research Study to See How Semaglutide Helps People With Excess Weight and Type 2 Diabetes Lose Weight

NCT05649137 · View on ClinicalTrials.gov ↗

Study Summary

This study will look at how much weight participants will lose and how much blood sugar control they achieve from the start to the end of the study. The weight loss in participants taking the investigational high dose of semaglutide will be compared to the weight loss in people taking "dummy" medicine and a lower dose of semaglutide. In addition to taking the medicine, participants will have talks with study staff about healthy food choices and how to be more physically active. Participants will either get semaglutide or "dummy" medicine. Which treatment participants get is decided by chance. Participants are more likely (4 out of 5) to get semaglutide than the "dummy" medicine. The study medicine will be injected briefly, under skin, with a thin needle, typically in the stomach, thighs, or upper arms. After receiving first dose, the dose of semaglutide will be gradually increased until reaching the target dose. The study will last for about 1.5 years

Interventions

  • DRUG Placebo
  • DRUG Semaglutide

Study Locations (20)

Texas

  • Amarillo Med Spec LLP — Amarillo
  • Elligo Clin Res Centre — Austin
  • Velocity Clin Res, Dallas — Dallas
  • UT Southwestern Medical Center - Lingvay — Dallas
  • PlanIt Research, PLLC — Houston
  • DCOL Ctr for Clin Res — Longview

Florida

  • ARS- Deland CRU — DeLand
  • Jacksonville Ctr for Clin Res — Jacksonville
  • Florida Inst For Clin Res LLC — Orlando
  • Oviedo Medical Research, LLC — Oviedo

California

  • John Muir Physicians Network — Concord
  • Velocity Clinical Research Westlake — Los Angeles
  • Diablo Clinical Research, Inc. — Walnut Creek

Alabama

  • Univ of Alabama Birmingham — Birmingham
  • Chambliss Clinical Trials, LLC — Montgomery

North Carolina

  • University of North Carolina — Chapel Hill
  • PharmQuest Life Sciences LLC — Greensboro

Colorado

  • New West Physicians PC — Golden

Georgia

  • Hope Clin Res & Wellness — Conyers

New York

  • AMC Community Endocrinology — Albany

Trial Details

FieldValue
Enrollment Target 512 participants
Start Date 2023-01-04
Est. Completion 2024-12-13
Phase Phase 3

Sponsor

Novo Nordisk A/S

189 total trials

Interested in This Trial?

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT05649137

The ClinicalTrials.gov registry entry for NCT05649137 describes a study currently listed as completed. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 512 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Novo Nordisk A/S, which has 189 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 2 conditions, with Obesity appearing as the primary indexed condition, and to 2 interventions — of which Placebo is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT05649137 reports 20 study locations spanning 8 distinct geographic areas — top geographies include Texas, Florida, California. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT05649137 about?

NCT05649137 is a clinical study titled "A Research Study to See How Semaglutide Helps People With Excess Weight and Type 2 Diabetes Lose Weight". This study will look at how much weight participants will lose and how much blood sugar control they achieve from the start to the end of the study. The weight loss in participants taking the investigational high dose of semaglutide will be compared to the weight loss in people taking "dummy" medici...

What is the current status of trial NCT05649137?

This trial is currently completed. It is a Phase 3 study. The enrollment target is 512 participants. The study started on 2023-01-04. Estimated completion is 2024-12-13.

What conditions does trial NCT05649137 study?

This clinical trial studies the following conditions: Obesity, Diabetes Mellitus, Type 2. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT05649137?

The interventions under investigation include: Placebo (DRUG), Semaglutide (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT05649137?

This trial is sponsored by Novo Nordisk A/S, which has 189 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT05649137 being conducted?

This trial has 20 study locations across Alabama, California, Colorado, Florida, Georgia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial