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Diabetes Mellitus, Type 2 clinical trials
63 of 351 indexed Diabetes Mellitus, Type 2 trials are currently recruiting.
351 US clinical trials · 63 currently recruiting
Diabetes Mellitus, Type 2 is the subject of 351 registered US clinical trials on ClinicalTrials.gov, 63 of them currently open to new participants. 100 are in Phase 3-4 (later-stage) and 80 in Phase 1-2 (earlier-stage). The most active sponsor is Novo Nordisk A/S, running 48 of these trials.
The research picture
Diabetes Mellitus, Type 2 has 351 registered US clinical trials, 63 of them open to new participants right now, about 18% of the total.
- 63
- recruiting participants now
- 18%
- of trials open to enrollment
- 100
- in Phase 3–4 (later-stage)
- 48
- top sponsor: Novo Nordisk A/S
Active & Recent Trials
351 total, page 5 of 8
A Study of GK Activator (2) in Patients With Type 2 Diabetes Mellitus
Hoffmann-La Roche
NCT00266240
Technology to Improve the Health of Resource-poor Hispanics With Diabetes
Baylor College of Medicine
NCT03394456
Evaluation of Blood Volume and Perceived Pain During Fingerstick Monitoring of Blood Glucose
Becton, Dickinson and Company
NCT00741390
A Study for Patients With Type 2 Diabetes Mellitus
Eli Lilly and Company
NCT00804986
A Research Study to Look Into How Well Semaglutide Medicine Works at Different Doses in People With Type 2 Diabetes and Overweight
Novo Nordisk A/S
NCT05486065
Randomized, Double-blind (db), Placebo-controlled 18 Week Study of Linagliptin (BI 1356) in Type 2 Diabetic Patients With Insufficient Glycaemic Control on a Sulfonylurea Drug
Boehringer Ingelheim
NCT00819091
Efficacy, Safety and Preference Study of a Insulin Pen PDS290 vs. a Novo Nordisk Marketed Insulin Pen in Diabetics
Novo Nordisk A/S
NCT00773279
Study In Postmenopausal Women With Type 2 Diabetes Looking At Approved Diabetes Drugs And How They Affect Bone Health
GlaxoSmithKline
NCT00679939
Benefits of Insulin Supplementation for Correction of Hyperglycemia in Patients With Type 2 Diabetes
Emory University
NCT02408120
Expanding Technology-Enabled Nurse Delivered Chronic Disease Care
Duke University
NCT05120544
A Study to Evaluate the Efficacy and Safety of the Addition of Canagliflozin in Participants With Type 2 Diabetes Mellitus With Inadequate Glycemic Control on Metformin and Sitagliptin
Janssen Research & Development
NCT02025907
Internet Intervention to Improve Rural Diabetes Care
University of Alabama at Birmingham
NCT00403091
Computerized Cognitive Training for Diabetic Elderly Veterans
VA Office of Research and Development
NCT01736124
A Study of Aleglitazar in Combination With Metformin in Patients With Type 2 Diabetes Mellitus Who Are Inadequately Controlled With Sulfonylurea Alone or Sulfonylurea Plus Metformin Therapy
Hoffmann-La Roche
NCT01691989
Improving Diabetic Patient Health Through Assistive-Reading Technology
GogyUp
NCT05337306
Study to Assess Safety and Effect of a Prebiotic Fiber Meal Replacement Shake in Individuals With Type 2 Diabetes
Uplifting Results Labs
NCT05110703
Add Glucokinase Activator to Target A1c
vTv Therapeutics
NCT02405260
Multi-Center Study Comparing Efficacy and Safety of Frequently Modified Insulin Therapy
Hygieia Research
NCT02424500
Type 2 Diabetes (T2D) Basal Insulin Users: The Mobile Study (MOBILE)
DexCom
NCT03566693
A Study to Investigate the Efficacy and Safety of Canagliflozin in Children and Adolescents (>=10 to <18 Years) With Type 2 Diabetes Mellitus
Janssen Research & Development
NCT03170518
Technology Intervention for Diabetes Engagement & Self-Care (TIDES)
Geisinger Clinic
NCT01440530
Impact of Community Health Workers on Adherence to Therapy for Non-Communicable Chronic Disease in Chiapas, Mexico
Brigham and Women's Hospital
NCT02549495
Regional Fat Depots and Insulin Resistance
Stanford University
NCT01336777
Defective Atypical Protein Kinase C (PKC) Activation in Diabetes and Metabolic Syndrome
VA Office of Research and Development
NCT00690755
Managing Type 1 and High Risk Type 2 Diabetes in the Hospital Setting: Glucose as a Vital Sign
Scripps Whittier Diabetes Institute
NCT03068273
Getting in Balance: A Workplace Diabetes Prevention Intervention Trial
Kaiser Permanente
NCT02589873
The Diabetes Medication Adherence Promotion Intervention Trial
Vanderbilt University
NCT02458495
Advanced Medical Therapy Versus Advanced Medical Therapy Plus Bariatric Surgery for the Resolution of Type 2 Diabetes
The Cleveland Clinic
NCT00432809
Evaluating a Web-Based Cardiovascular Disease Risk Factor Reduction Program Among American Indians
Black Hills Center for American Indian Health
NCT00608387
Lifestyle Intervention's Impact on Health Care Costs
University of Virginia
NCT00717158
Switching From Insulin Glargine to Insulin Degludec in Subjects With Type 2 Diabetes Mellitus (BEGIN™)
Novo Nordisk A/S
NCT01135992
SomaSignal Tests on Medical Management and Change in Risk in Patients With Diabetes
Emory University
NCT05256706
Screening, Brief Intervention, and Referral to Treatment in Primary Care
Duke University
NCT01966432
Safety and Efficacy in Type 2 Diabetic Patients With Severe Chronic Renal Impairment, 5 mg BI 1356 (Linagliptin) vs. Placebo, Insulin Background Inclusive
Boehringer Ingelheim
NCT00800683
A Research Study to Compare a New Medicine Oral Semaglutide to a Dummy Medicine in Children and Teenagers With Type 2 Diabetes
Novo Nordisk A/S
NCT04596631
A Randomized, Double-Blind, Comparator- and Placebo-Controlled, Multiple-Dose Study to Evaluate the Safety, Tolerability and Efficacy of Three Dose Levels of MSDC-0602 in Type 2 Diabetic Patients
Metabolic Solutions Development Company
NCT01280695
A Study of RO5095932 in Patients With Type 2 Diabetes Mellitus
Hoffmann-La Roche
NCT00961909
PF-06291874 Multiple Ascending Dose Study In Type 2 Diabetes Mellitus Patients
Pfizer
NCT01856595
Managing Diabetes to Gain Opportunities for a More Active Life
University of Chicago
NCT03692208
Clinical Trial of SB-509 in Subjects With Diabetic Neuropathy
Sangamo Therapeutics
NCT00406458
A Research Study to Find Out How Semaglutide Works in the Kidneys Compared to Placebo, in People With Type 2 Diabetes and Chronic Kidney Disease (the REMODEL Trial)
Novo Nordisk A/S
NCT04865770
Dietary Approaches to Stop Hypertension for Diabetes
Johns Hopkins University
NCT04286555
Ticagrelor With and Without Aspirin in Patients With Diabetes Mellitus
University of Florida
NCT04484259
Delivering Health: Addressing Diabetes and Food Insecurity
University of Arkansas
NCT04831216
A Study of LC542019 in Healthy Subjects and Subjects With T2DM
LG Chem
NCT06333977
A Sub-study to LMF237A2302 to Assess the Effect of 24 Weeks Treatment With Initial Combination of Vildagliptin Plus Metformin
Novartis
NCT00468039
A Study of GSK256073 in Subjects With Type 2 Diabetes Mellitus Who Are Being Treated With Metformin
GlaxoSmithKline
NCT01376323
T2D Pilot Study for Patients With Uncontrolled Type 2 Diabetes
Duke University
NCT06988540
Clinical Trial of SB-509 in Subjects With Diabetic Neuropathy
Sangamo Therapeutics
NCT00476931
Single-Dose And Multiple-Dose Safety And Tolerability Study Of PF-04856883 In Type 2 Diabetic Adult Females
Pfizer
NCT01301456
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 42 |
| Phase 2 | 38 |
| Phase 3 | 74 |
| Phase 4 | 26 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Diabetes Mellitus, Type 2 Trial Landscape
351 indexed Diabetes Mellitus, Type 2 studies · 63 recruiting (18%).
Phase mix: 100 late (III/IV) vs 80 early (I/II).
Top sponsor: Novo Nordisk A/S (48 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Diabetes Mellitus, Type 2?
PlainTrial tracks 351 US clinical trials for Diabetes Mellitus, Type 2, of which 63 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Diabetes Mellitus, Type 2?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.