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NCT05426967 · ClinicalTrials.gov registry record · NA

rTMS for Military TBI-related Depression

A NA study of Depressive Symptoms and Mild Traumatic Brain Injury, sponsored by Henry M. Jackson Foundation for the Advancement of Military Medicine.

Recruiting
Registry status
NA
Development phase
198
Enrollment target
3
Study locations

NCT05426967: Recruiting NA study of Depressive Symptoms and Mild Traumatic Brain Injury, sponsored by Henry M. Jackson Foundation for the Advancement of Military Medicine.

NCT05426967 is a NA study of Depressive Symptoms and Mild Traumatic Brain Injury that is actively recruiting participants, run by Henry M. Jackson Foundation for the Advancement of Military Medicine. The registered enrollment target is 198 participants, below the 258-participant average among 60 other Depressive Symptoms trials with a reported enrollment target (23% lower). The trial reports 3 study locations across 3 states. According to ClinicalTrials.gov, the official US trial registry.

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The verdict

NCT05426967, a NA study of Depressive Symptoms and Mild Traumatic Brain Injury, is actively recruiting participants, sponsored by Henry M. Jackson Foundation for the Advancement of Military Medicine.

RECRUITING
Registry status
NA
Development phase
198 participants
Enrollment target
3
Study locations

Study Summary

The purpose of this study is to investigate the efficacy, safety, and tolerability of two dorsolateral prefrontal cortex (DLPFC) repetitive transcranial magnetic stimulation (rTMS) protocols to alleviate symptoms of depression in United States (U.S.) military service members and veterans with a history of concussion/mild traumatic brain injury (TBI).

Primary Outcome

Change in Montgomery-Asberg Depression Rating Scale scores from baseline to post-intervention between groups. The Scale is designed to measure depression severity and consists of 10 items, each of which is scored on a Likert scale from 0 (item not present or normal) to 6 (severe or continuous presence of the symptoms), for a total possible score of 60. Higher scores represent a more severe condition.

Conditions Studied

Depressive Symptoms Mild Traumatic Brain Injury Concussion

Interventions

  • DEVICE Repetitive Transcranial Magnetic Stimulation (rTMS)
  • DEVICE Sham rTMS

Study Locations (3)

California

  • VA Palo Alto Health Care System - Palo Alto

Texas

  • William Beaumont Army Medical Center - Fort Bliss

Virginia

  • Alexander T. Augusta Military Medical Center - Fort Belvoir

Trial Details

FieldValue
Enrollment Target 198 participants
Start Date 2024-12-16
Est. Completion 2026-12-31
Phase NA
Henry M. Jackson Foundation for the Advancement of Military Medicine

60 total trials

What NCT05426967 shows while recruiting

NCT05426967 is an interventional study that assigns participants to a tested intervention. The registered 198 participants enrollment target is mid-sized for trials with a published cap, below the 258-participant average among 60 other Depressive Symptoms trials with a reported enrollment target (23% lower).

The record links to 3 conditions, with Depressive Symptoms appearing as the primary indexed condition, and to 2 interventions - of which Repetitive Transcranial Magnetic Stimulation (rTMS) is the first listed.

NCT05426967 reports a single indexed study location in California, Texas, Virginia.

Frequently Asked Questions

What is clinical trial NCT05426967 about?

NCT05426967 is a clinical study titled "rTMS for Military TBI-related Depression". The purpose of this study is to investigate the efficacy, safety, and tolerability of two dorsolateral prefrontal cortex (DLPFC) repetitive transcranial magnetic stimulation (rTMS) protocols to alleviate symptoms of depression in United States (U.S.) military service members and veterans with a hist...

What is the current status of trial NCT05426967?

This trial is currently recruiting. It is a NA study. The enrollment target is 198 participants. The study started on 2024-12-16. Estimated completion is 2026-12-31.

What conditions does trial NCT05426967 study?

This clinical trial studies the following conditions: Depressive Symptoms, Mild Traumatic Brain Injury, Concussion.

What interventions are being tested in trial NCT05426967?

The interventions under investigation include: Repetitive Transcranial Magnetic Stimulation (rTMS) (DEVICE), Sham rTMS (DEVICE).

Who is sponsoring clinical trial NCT05426967?

This trial is sponsored by Henry M. Jackson Foundation for the Advancement of Military Medicine, which has 60 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT05426967 being conducted?

This trial has 3 study locations across California, Texas, Virginia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Learn More About Clinical Trials

Similar trials for Depressive Symptoms

Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.

Where NCT05426967's enrollment target sits among peer trials

198 13th of 60 higher than 48 of 60 other Depressive Symptoms trials

participants (enrollment target), bucketed by value

Each bar is a band; taller bars hold more other Depressive Symptoms trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.

Source ClinicalTrials.gov registry export · 2026-08-08

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More recruiting context for NCT05426967

Source: ClinicalTrials.gov NCT05426967, the US trial registry maintained by the National Library of Medicine. NCT05426967 (mid enrollment · single site footprint · recruiting) retrieved and formatted by PlainTrial, see methodology.