Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Depressive Symptoms: early-phase trial registry
28 of 61 indexed Depressive Symptoms trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #232 of 28,707 conditions by registered trial count.
61 US clinical trials · 28 currently recruiting · #232 of 28,707 conditions by registered trial count
Depressive Symptoms: 61 US clinical trials tracked, 28 recruiting.
Depressive Symptoms is the subject of 61 registered US clinical trials on ClinicalTrials.gov, 28 of them currently open to new participants. 1 are in Phase 3-4 (later-stage) and 5 in Phase 1-2 (earlier-stage). The most active sponsor is Johns Hopkins University, running 3 of these trials.
Enrollment posture brief
Registry condition depressive-symptoms
OPEN 28 | RECR 46% | LATE 1 | EARLY 5 | RANK #232 | SPON 3
Volume-matched condition peers
Nearest open-share peer: Breastfeeding (46% recruiting · 37 trials)
Depressive Symptoms lists 28 open slots (46% of 61 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Depressive Symptoms on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Depressive Symptoms is recruiting above its size-band peers.
28 of 61 indexed trials (45.9%) are open to enrollment, against a 39.7% average across 762 conditions with 20-99 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Depressive Symptoms trials is spread across many organizations.
Johns Hopkins University accounts for 3 of 61 trials (4.9%). 49 distinct sponsors appear on at least one study for this condition label.
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Typical Depressive Symptoms enrolment sits around 96 participants.
Median target enrolment is 96 among the 61 trials that report a genuine target (sentinel values excluded). 31 of those (50.8%) plan for fewer than 100 participants.
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Depressive Symptoms research is mostly interventional.
59 interventional and 2 observational studies make up this index (96.7% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
61 total, page 2 of 2
Testing a Positive Psychology-based Intervention for Couples Coping With Stroke
University of Utah
NCT03335358
Stepped-Care Telehealth for Distress in Cancer Survivors
Wake Forest University Health Sciences
NCT03060096
Accelerated Resolution Therapy for Complicated Grief
University of South Florida
NCT03484338
Examine the Effects of Meditation on Daily Psychological Stress Responses in Woman With a History of Child Adversity
University of California, San Francisco
NCT04606199
Stress-reduction Wellness Program for Midlife Black Women (B-SWELL)
University of Cincinnati
NCT04404478
Vitamin D for Improving Metabolic Control and Depressive Symptoms
Loyola University
NCT01185574
Attachment and Biobehavioral Catch-up for Depression
University of California, San Francisco
NCT04050202
Beating the Blues for Your Heart
Indiana University
NCT01605552
Internet-Based Cognitive Behavioral Therapy for Depressive Symptoms in Adolescents With Type 1 Diabetes Mellitus
University of Texas Southwestern Medical Center
NCT03655067
Can Rumination-Focused Cognitive Behavioral Therapy Reduce the Risk of Cardio-vascular Disease?
University of Louisville
NCT05980130
Programs to Support You During Chemotherapy (Pro-You)
Vanderbilt-Ingram Cancer Center
NCT02148406
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 1 |
| Phase 2 | 4 |
| Phase 4 | 1 |
Top Sponsors
Named interventions
Most-linked intervention names on Depressive Symptoms records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Depressive Symptoms trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Depressive Symptoms page
61 registered trials, 28 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 28 Depressive Symptoms trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Johns Hopkins University sponsors the most Depressive Symptoms trials on record, review their full trial history before evaluating a specific study. See Johns Hopkins University's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Depressive Symptoms condition card totals 61 registered trials; most-linked intervention EMSELLA (HPM-6000UF) Sham Treatment; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.