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Depressive Symptoms clinical trials
28 of 61 indexed Depressive Symptoms trials are currently recruiting.
61 US clinical trials · 28 currently recruiting
Depressive Symptoms is the subject of 61 registered US clinical trials on ClinicalTrials.gov, 28 of them currently open to new participants. 1 are in Phase 3-4 (later-stage) and 5 in Phase 1-2 (earlier-stage). The most active sponsor is Johns Hopkins University, running 3 of these trials.
The research picture
Depressive Symptoms has 61 registered US clinical trials, 28 of them open to new participants right now, about 46% of the total.
- 28
- recruiting participants now
- 46%
- of trials open to enrollment
- 1
- in Phase 3–4 (later-stage)
- 3
- top sponsor: Johns Hopkins University
Active & Recent Trials
61 total, page 2 of 2
Testing a Positive Psychology-based Intervention for Couples Coping With Stroke
University of Utah
NCT03335358
Stepped-Care Telehealth for Distress in Cancer Survivors
Wake Forest University Health Sciences
NCT03060096
Accelerated Resolution Therapy for Complicated Grief
University of South Florida
NCT03484338
Examine the Effects of Meditation on Daily Psychological Stress Responses in Woman With a History of Child Adversity
University of California, San Francisco
NCT04606199
Stress-reduction Wellness Program for Midlife Black Women (B-SWELL)
University of Cincinnati
NCT04404478
Vitamin D for Improving Metabolic Control and Depressive Symptoms
Loyola University
NCT01185574
Attachment and Biobehavioral Catch-up for Depression
University of California, San Francisco
NCT04050202
Beating the Blues for Your Heart
Indiana University
NCT01605552
Internet-Based Cognitive Behavioral Therapy for Depressive Symptoms in Adolescents With Type 1 Diabetes Mellitus
University of Texas Southwestern Medical Center
NCT03655067
Can Rumination-Focused Cognitive Behavioral Therapy Reduce the Risk of Cardio-vascular Disease?
University of Louisville
NCT05980130
Programs to Support You During Chemotherapy (Pro-You)
Vanderbilt-Ingram Cancer Center
NCT02148406
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 1 |
| Phase 2 | 4 |
| Phase 4 | 1 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Depressive Symptoms Trial Landscape
61 indexed Depressive Symptoms studies · 28 recruiting (46%).
Phase mix: 1 late (III/IV) vs 5 early (I/II).
Top sponsor: Johns Hopkins University (3 trials), 9 others listed. 11 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Depressive Symptoms?
PlainTrial tracks 61 US clinical trials for Depressive Symptoms, of which 28 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Depressive Symptoms?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.