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NCT06946225 · ClinicalTrials.gov registry record · Phase 1
ACTengine® IMA203 Combined With mRNA-4203
A Phase 1 study of Cutaneous Melanoma and Synovial Sarcoma, sponsored by Immatics US.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 15
- Enrollment target
- 4
- Study locations
NCT06946225: Recruiting Phase 1 study of Cutaneous Melanoma and Synovial Sarcoma, sponsored by Immatics US.
NCT06946225 is a Phase 1 study of Cutaneous Melanoma and Synovial Sarcoma that is actively recruiting participants, run by Immatics US. The registered enrollment target is 15 participants, below the 367-participant average among 30 other Cutaneous Melanoma trials with a reported enrollment target (96% lower). The trial reports 4 study locations across 4 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06946225, a Phase 1 study of Cutaneous Melanoma and Synovial Sarcoma, is actively recruiting participants, sponsored by Immatics US.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 15 participants
- Enrollment target
- 4
- Study locations
Study Summary
This purpose of this clinical trial is to evaluate the safety, tolerability and anti-tumor activity of IMA203 in combination with different doses of mRNA-4203. The trial includes participants with previously treated unresectable or metastatic cutaneous melanoma (CM) or synovial sarcoma (SS).
Primary Outcome
Number of DLTs will be used to determine the maximum tolerated dose (MTD) and/or recommended dose for extension (RDE) after treatment with IMA203 product in combination with mRNA-4203
Conditions Studied
Interventions
- BIOLOGICAL IMA203
- BIOLOGICAL mRNA-4203
Study Locations (4)
California
- University of California San Francisco - San Francisco
Massachusetts
- Dana Farber Cancer Institute - Boston
New York
- Memorial Sloan Kettering Cancer Center - New York
Texas
- MD Anderson Cancer Center - Houston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 15 participants |
| Start Date | 2025-07-25 |
| Est. Completion | 2029-08 |
| Phase | Phase 1 |
What NCT06946225 shows while recruiting
NCT06946225 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 15 participants, a relatively small participant target, below the 367-participant average among 30 other Cutaneous Melanoma trials with a reported enrollment target (96% lower).
The record links to 2 conditions, with Cutaneous Melanoma appearing as the primary indexed condition, and to 2 interventions - of which IMA203 is the first listed.
NCT06946225 reports a single indexed study location in California, Massachusetts, New York.
Frequently Asked Questions
What is clinical trial NCT06946225 about?
NCT06946225 is a clinical study titled "ACTengine® IMA203 Combined With mRNA-4203". This purpose of this clinical trial is to evaluate the safety, tolerability and anti-tumor activity of IMA203 in combination with different doses of mRNA-4203. The trial includes participants with previously treated unresectable or metastatic cutaneous melanoma (CM) or synovial sarcoma (SS).
What is the current status of trial NCT06946225?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 15 participants. The study started on 2025-07-25. Estimated completion is 2029-08.
What conditions does trial NCT06946225 study?
This clinical trial studies the following conditions: Cutaneous Melanoma, Synovial Sarcoma.
What interventions are being tested in trial NCT06946225?
The interventions under investigation include: IMA203 (BIOLOGICAL), mRNA-4203 (BIOLOGICAL).
Who is sponsoring clinical trial NCT06946225?
This trial is sponsored by Immatics US, which has 7 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06946225 being conducted?
This trial has 4 study locations across California, Massachusetts, New York, Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Cutaneous Melanoma
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06946225's enrollment target sits among peer trials
15 29th of 30 higher than 2 of 30 other Cutaneous Melanoma trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Cutaneous Melanoma trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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