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NCT07148245 · ClinicalTrials.gov registry record
Symptoms of Immune Checkpoint Inhibitor Therapy in Cutaneous Melanoma
A clinical trial of Cutaneous Melanoma and Cutaneous Melanoma, Stage III, sponsored by University of California, San Francisco.
- Recruiting
- Registry status
- 300
- Enrollment target
- 1
- Study location
NCT07148245: Recruiting study of Cutaneous Melanoma and Cutaneous Melanoma, Stage III, sponsored by University of California, San Francisco.
NCT07148245 is a study of Cutaneous Melanoma and Cutaneous Melanoma, Stage III that is actively recruiting participants, run by University of California, San Francisco. The registered enrollment target is 300 participants, below the 357-participant average among 30 other Cutaneous Melanoma trials with a reported enrollment target (16% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07148245, a study of Cutaneous Melanoma and Cutaneous Melanoma, Stage III, is actively recruiting participants, sponsored by University of California, San Francisco.
- RECRUITING
- Registry status
- 300 participants
- Enrollment target
- 1
- Study location
Study Summary
The introduction of immune checkpoint inhibitors (ICIs) for the treatment of patients with stages IIB to IV cutaneous melanoma resulted in dramatic improvements in mortality rates for this common form of cancer. With this rapid shift in treatment, significant gaps in knowledge exist regarding the impact of ICIs on patients' symptom experiences. An in-depth characterization of inter-individual differences in patients' symptom experiences will fill this knowledge gap and assist with the early detection of ICI toxicity; guide symptom management; inform treatment decision making; and refine ICI-symptom instrument development. Furthermore, given the limited knowledge in this area, the identification of demographic, clinical, environmental, and molecular risk factors associated with a worse symptom experience is warranted. This is a longitudinal, prospective study evaluating the symptoms that immune checkpoint inhibitors may cause in patients with cutaneous melanoma.
Primary Outcome
Evaluations of symptoms over time will be assessed via calculating the occurrence rates and means and standard deviations for the severity and distress ratings for all 53 symptoms and determine the most common, severe, and distressing symptoms over time.
Conditions Studied
Interventions
- OTHER Medical Chart Review
- PROCEDURE Blood Sample
- OTHER Health Related Quality of Life Questionnaires (HRQoL)
Study Locations (1)
California
- University of California, San Francisco - San Francisco
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 300 participants |
| Start Date | 2025-10-13 |
| Est. Completion | 2027-06-30 |
What NCT07148245 shows while recruiting
NCT07148245 is an observational study that tracks outcomes without assigning an intervention. The registered 300 participants enrollment target is mid-sized for trials with a published cap, below the 357-participant average among 30 other Cutaneous Melanoma trials with a reported enrollment target (16% lower).
The record links to 4 conditions, with Cutaneous Melanoma appearing as the primary indexed condition, and to 3 interventions - of which Medical Chart Review is the first listed.
NCT07148245 reports a single indexed study location in California.
Frequently Asked Questions
What is clinical trial NCT07148245 about?
NCT07148245 is a clinical study titled "Symptoms of Immune Checkpoint Inhibitor Therapy in Cutaneous Melanoma". The introduction of immune checkpoint inhibitors (ICIs) for the treatment of patients with stages IIB to IV cutaneous melanoma resulted in dramatic improvements in mortality rates for this common form of cancer. With this rapid shift in treatment, significant gaps in knowledge exist regarding the im...
What is the current status of trial NCT07148245?
This trial is currently recruiting. The enrollment target is 300 participants. The study started on 2025-10-13. Estimated completion is 2027-06-30.
What conditions does trial NCT07148245 study?
This clinical trial studies the following conditions: Cutaneous Melanoma, Cutaneous Melanoma, Stage III, Cutaneous Melanoma by AJCC V7 Stage, Cutaneous Melanoma, Stage IV.
What interventions are being tested in trial NCT07148245?
The interventions under investigation include: Medical Chart Review (OTHER), Blood Sample (PROCEDURE), Health Related Quality of Life Questionnaires (HRQoL) (OTHER).
Who is sponsoring clinical trial NCT07148245?
This trial is sponsored by University of California, San Francisco, which has 1,713 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07148245 being conducted?
This trial has 1 study location across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT07148245's enrollment target sits among peer trials
300 8th of 30 higher than 23 of 30 other Cutaneous Melanoma trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Cutaneous Melanoma trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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