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COMPLETED Phase 1

A Study of Anti-PD-L1 Checkpoint Antibody (LY3300054) Alone and in Combination in Participants With Advanced Refractory Solid Tumors

NCT02791334 · View on ClinicalTrials.gov ↗

Study Summary

The main purpose of this study is to evaluate the safety and tolerability of anti-programmed cell death ligand 1 (PD-L1) checkpoint antibody LY3300054 in participants with advanced refractory solid tumors.

Interventions

  • DRUG Abemaciclib
  • DRUG Ramucirumab
  • DRUG Merestinib
  • DRUG LY3300054
  • DRUG LY3321367

Study Locations (14)

Other

  • Cliniques Universitaires Saint-Luc — Brussels
  • Universitair Ziekenhuis Antwerpen — Edegem
  • Institut Bergonié - Centre Régional de Lutte Contre Le Cancer de Bordeaux et Sud Ouest — Bordeaux
  • Gustave Roussy — Villejuif
  • Seoul National University Hospital — Seoul
  • Severance Hospital Yonsei University Health System — Seoul
  • Hospital Universitario Fundación Jiménez Díaz — Madrid
  • Hospital Madrid Norte Sanchinarro — Madrid
  • National Cheng Kung University Hospital — Tainan
  • National Taiwan University Hospital — Taipei

Texas

  • University of Texas MD Anderson Cancer Center — Houston
  • The START Center for Cancer Care — San Antonio

Tennessee

  • Tennessee Oncology PLLC — Nashville

Ontario

  • Princess Margaret Hospital — Toronto

Trial Details

FieldValue
Enrollment Target 164 participants
Start Date 2016-06-29
Est. Completion 2024-06-27
Phase Phase 1

Sponsor

Eli Lilly and Company

704 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT02791334

The ClinicalTrials.gov registry entry for NCT02791334 describes a study currently listed as completed. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 164 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Eli Lilly and Company, which has 704 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 5 conditions, with Pancreatic Cancer appearing as the primary indexed condition, and to 5 interventions — of which Abemaciclib is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT02791334 reports 14 study locations spanning 4 distinct geographic areas — top geographies include Other, Texas, Tennessee. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT02791334 about?

NCT02791334 is a clinical study titled "A Study of Anti-PD-L1 Checkpoint Antibody (LY3300054) Alone and in Combination in Participants With Advanced Refractory Solid Tumors". The main purpose of this study is to evaluate the safety and tolerability of anti-programmed cell death ligand 1 (PD-L1) checkpoint antibody LY3300054 in participants with advanced refractory solid tumors.

What is the current status of trial NCT02791334?

This trial is currently completed. It is a Phase 1 study. The enrollment target is 164 participants. The study started on 2016-06-29. Estimated completion is 2024-06-27.

What conditions does trial NCT02791334 study?

This clinical trial studies the following conditions: Pancreatic Cancer, Solid Tumor, Cutaneous Melanoma, Microsatellite Instability-High (MSI-H) Solid Tumors, Breast Cancer (HR+HER2-). These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT02791334?

The interventions under investigation include: Abemaciclib (DRUG), Ramucirumab (DRUG), Merestinib (DRUG), LY3300054 (DRUG), LY3321367 (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT02791334?

This trial is sponsored by Eli Lilly and Company, which has 704 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT02791334 being conducted?

This trial has 14 study locations across Tennessee, Texas, Ontario. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial