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NCT03842943 · ClinicalTrials.gov registry record · Phase 2
Neoadjuvant Combination Immunotherapy for Stage III Melanoma
A Phase 2 study of Cutaneous Melanoma, sponsored by University of Louisville.
- Recruiting
- Registry status
- Phase 2
- Development phase
- 28
- Enrollment target
- 1
- Study location
NCT03842943: Recruiting Phase 2 study of Cutaneous Melanoma, sponsored by University of Louisville.
NCT03842943 is a Phase 2 study of Cutaneous Melanoma that is actively recruiting participants, run by University of Louisville. The registered enrollment target is 28 participants, below the 366-participant average among 30 other Cutaneous Melanoma trials with a reported enrollment target (92% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03842943, a Phase 2 study of Cutaneous Melanoma, is actively recruiting participants, sponsored by University of Louisville.
- RECRUITING
- Registry status
- Phase 2
- Development phase
- 28 participants
- Enrollment target
- 1
- Study location
Study Summary
Determine safety and efficacy of pre-operative combination immunotherapy with Talimogene Laherparepvec (T-VEC)/Pembrolizumab given prior to complete lymph node dissection in resectable stage 3 cutaneous melanoma with clinically apparent lymph node metastases.
Primary Outcome
Pathologic response rate in the regional nodal basin assessed after complete lymph node dissection
Conditions Studied
Interventions
- DRUG Pembrolizumab
- DRUG Talimogene Laherparepvec
Study Locations (1)
Kentucky
- University of Louisville - Louisville
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 28 participants |
| Start Date | 2019-07-03 |
| Est. Completion | 2028-06-01 |
| Phase | Phase 2 |
What NCT03842943 shows while recruiting
NCT03842943 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 28 participants, a relatively small participant target, below the 366-participant average among 30 other Cutaneous Melanoma trials with a reported enrollment target (92% lower).
The record links to 1 condition, with Cutaneous Melanoma appearing as the primary indexed condition, and to 2 interventions - of which Pembrolizumab is the first listed.
NCT03842943 reports a single indexed study location in Kentucky.
Frequently Asked Questions
What is clinical trial NCT03842943 about?
NCT03842943 is a clinical study titled "Neoadjuvant Combination Immunotherapy for Stage III Melanoma". Determine safety and efficacy of pre-operative combination immunotherapy with Talimogene Laherparepvec (T-VEC)/Pembrolizumab given prior to complete lymph node dissection in resectable stage 3 cutaneous melanoma with clinically apparent lymph node metastases.
What is the current status of trial NCT03842943?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 28 participants. The study started on 2019-07-03. Estimated completion is 2028-06-01.
What conditions does trial NCT03842943 study?
This clinical trial studies the following conditions: Cutaneous Melanoma.
What interventions are being tested in trial NCT03842943?
The interventions under investigation include: Pembrolizumab (DRUG), Talimogene Laherparepvec (DRUG).
Who is sponsoring clinical trial NCT03842943?
This trial is sponsored by University of Louisville, which has 217 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT03842943 being conducted?
This trial has 1 study location across Kentucky. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Cutaneous Melanoma
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT03842943's enrollment target sits among peer trials
28 23rd of 30 higher than 8 of 30 other Cutaneous Melanoma trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Cutaneous Melanoma trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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