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NCT00655980 · ClinicalTrials.gov registry record · NA
Vitamins in Nitrous Oxide Study
A NA study of Coronary Artery Disease and Major Surgery, sponsored by Washington University School of Medicine.
- Completed
- Registry status
- NA
- Development phase
- 687
- Enrollment target
- 1
- Study location
NCT00655980: Completed NA study of Coronary Artery Disease and Major Surgery, sponsored by Washington University School of Medicine.
NCT00655980 is a NA study of Coronary Artery Disease and Major Surgery that has completed, run by Washington University School of Medicine. The registered enrollment target is 687 participants, below the 1,284-participant average among 219 other Coronary Artery Disease trials with a reported enrollment target (46% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00655980, a NA study of Coronary Artery Disease and Major Surgery, has completed, sponsored by Washington University School of Medicine.
- COMPLETED
- Registry status
- NA
- Development phase
- 687 participants
- Enrollment target
- 1
- Study location
Study Summary
In this study, we want to find out if laughing gas (nitrous oxide) leads to a higher rate of cardiac complications after surgery in patients with a specific genetic profile (mutations in the MTHFR gene) and if this risk can be prevented by giving patients vitamin B12 and folate during surgery.
Primary Outcome
Measured by serial troponin and ECG
Conditions Studied
Interventions
- OTHER standard of care
- DRUG Vitamin B12 and folic acid
- DRUG Nitrous oxide and placebo
Study Locations (1)
Missouri
- Barnes-Jewish Hospital - St Louis
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 687 participants |
| Start Date | 2008-02 |
| Est. Completion | 2016-12 |
| Phase | NA |
What the finished NCT00655980 record still lists
NCT00655980 is an interventional study that assigns participants to a tested intervention. The registered 687 participants enrollment target is mid-sized for trials with a published cap, below the 1,284-participant average among 219 other Coronary Artery Disease trials with a reported enrollment target (46% lower).
The record links to 2 conditions, with Coronary Artery Disease appearing as the primary indexed condition, and to 3 interventions - of which standard of care is the first listed.
NCT00655980 reports a single indexed study location in Missouri.
Frequently Asked Questions
What is clinical trial NCT00655980 about?
NCT00655980 is a clinical study titled "Vitamins in Nitrous Oxide Study". In this study, we want to find out if laughing gas (nitrous oxide) leads to a higher rate of cardiac complications after surgery in patients with a specific genetic profile (mutations in the MTHFR gene) and if this risk can be prevented by giving patients vitamin B12 and folate during surgery.
What is the current status of trial NCT00655980?
This trial is currently completed. It is a NA study. The enrollment target is 687 participants. The study started on 2008-02. Estimated completion is 2016-12.
What conditions does trial NCT00655980 study?
This clinical trial studies the following conditions: Coronary Artery Disease, Major Surgery.
What interventions are being tested in trial NCT00655980?
The interventions under investigation include: standard of care (OTHER), Vitamin B12 and folic acid (DRUG), Nitrous oxide and placebo (DRUG).
Who is sponsoring clinical trial NCT00655980?
This trial is sponsored by Washington University School of Medicine, which has 1,502 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT00655980 being conducted?
This trial has 1 study location across Missouri. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Coronary Artery Disease
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT00655980's enrollment target sits among peer trials
687 64th of 219 higher than 156 of 219 other Coronary Artery Disease trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Coronary Artery Disease trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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