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ACTIVE NOT RECRUITING Phase 2

Axitinib With or Without Anti-OX40 Antibody PF-04518600 in Treating Patients With Metastatic Kidney Cancer

NCT03092856 · View on ClinicalTrials.gov ↗

Study Summary

This randomized phase II trial studies how well axitinib with or without anti-OX40 antibody PF-04518600 work in treating patients with kidney cancer that has spread to other parts of the body. Biological therapies, such as anti-OX40 antibody PF-04518600, use substances made from living organisms that may may stimulate the immune system in different ways and stop tumor cells from growing. Axitinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Giving axitinib with or without anti-OX40 antibody PF-04518600 may work better in treating patients with kidney cancer.

Interventions

  • OTHER Placebo
  • OTHER Laboratory Biomarker Analysis
  • DRUG Axitinib
  • BIOLOGICAL Anti-OX40 Antibody PF-04518600

Study Locations (10)

California

  • Los Angeles County-USC Medical Center — Los Angeles
  • USC / Norris Comprehensive Cancer Center — Los Angeles
  • USC Norris Oncology/Hematology-Newport Beach — Newport Beach
  • University of California Davis Comprehensive Cancer Center — Sacramento

Ohio

  • Cleveland Clinic Taussig Cancer Institute, Case Comprehensive Cancer Center — Cleveland
  • Ohio State University Comprehensive Cancer Center — Columbus

Kansas

  • University of Kansas Cancer Center — Kansas City

New York

  • Weill Cornell Medical College, New York- Presbyterian Hospital — New York

Pennsylvania

  • University of Pittsburgh Cancer Institute (UPCI) — Pittsburgh

Virginia

  • University of Virginia Cancer Center — Charlottesville

Trial Details

FieldValue
Enrollment Target 62 participants
Start Date 2017-07-19
Est. Completion 2026-12-31
Phase Phase 2

Sponsor

University of Southern California

412 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT03092856

The ClinicalTrials.gov registry entry for NCT03092856 describes a study currently listed as active not recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 62 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is University of Southern California, which has 412 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 4 conditions, with Clear Cell Renal Cell Carcinoma appearing as the primary indexed condition, and to 4 interventions — of which Placebo is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT03092856 reports 10 study locations spanning 6 distinct geographic areas — top geographies include California, Ohio, Kansas. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT03092856 about?

NCT03092856 is a clinical study titled "Axitinib With or Without Anti-OX40 Antibody PF-04518600 in Treating Patients With Metastatic Kidney Cancer". This randomized phase II trial studies how well axitinib with or without anti-OX40 antibody PF-04518600 work in treating patients with kidney cancer that has spread to other parts of the body. Biological therapies, such as anti-OX40 antibody PF-04518600, use substances made from living organisms tha...

What is the current status of trial NCT03092856?

This trial is currently active not recruiting. It is a Phase 2 study. The enrollment target is 62 participants. The study started on 2017-07-19. Estimated completion is 2026-12-31.

What conditions does trial NCT03092856 study?

This clinical trial studies the following conditions: Clear Cell Renal Cell Carcinoma, Stage IV Renal Cell Cancer, Metastatic Renal Cell Cancer, Recurrent Renal Cell Carcinoma. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT03092856?

The interventions under investigation include: Placebo (OTHER), Laboratory Biomarker Analysis (OTHER), Axitinib (DRUG), Anti-OX40 Antibody PF-04518600 (BIOLOGICAL). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT03092856?

This trial is sponsored by University of Southern California, which has 412 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT03092856 being conducted?

This trial has 10 study locations across California, Kansas, New York, Ohio, Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial