Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.

COMPLETED Phase 1

Total-Body Irradiation and Fludarabine Phosphate Followed by Donor Peripheral Blood Stem Cell Transplant in Treating Patients With Hematologic Malignancies or Kidney Cancer

NCT00027820 · View on ClinicalTrials.gov ↗

Study Summary

This phase I/II trial studies whether a new kind of blood stem cell (bone marrow) transplant, that may be less toxic, is able to treat underlying blood cancer. Stem cells are "seed cells" necessary to make blood cells. Researchers want to see if using less radiation and less chemotherapy with new immune suppressing drugs will enable a stem cell transplant to work. Researchers are hoping to see a mixture of recipient and donor stem cells after transplant. This mixture of donor and recipient stem cells is called "mixed-chimerism". Researchers hope to see these donor cells eliminate tumor cells. This is called a "graft-versus-leukemia" response.

Interventions

  • RADIATION Total-Body Irradiation
  • DRUG Fludarabine Phosphate
  • PROCEDURE Peripheral Blood Stem Cell Transplantation
  • DRUG Cyclosporine
  • PROCEDURE Nonmyeloablative Allogeneic Hematopoietic Stem Cell Transplantation

Study Locations (10)

Other

  • Universitaet Leipzig — Leipzig
  • University of Torino — Torino

Arizona

  • University of Arizona Health Sciences Center — Tucson

California

  • Stanford University Hospitals and Clinics — Stanford

Georgia

  • Emory University/Winship Cancer Institute — Atlanta

Oregon

  • OHSU Knight Cancer Institute — Portland

Texas

  • Baylor Medical Center at Garland — Garland

Utah

  • Huntsman Cancer Institute/University of Utah — Salt Lake City

Washington

  • Fred Hutchinson Cancer Research Center/University of Washington Cancer Consortium — Seattle

Trial Details

FieldValue
Enrollment Target 106 participants
Start Date 2001-08
Est. Completion 2004-09-05
Phase Phase 1

Sponsor

Fred Hutchinson Cancer Center

319 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT00027820

The ClinicalTrials.gov registry entry for NCT00027820 describes a study currently listed as completed. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 106 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Fred Hutchinson Cancer Center, which has 319 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 10 conditions, with Chronic Myelomonocytic Leukemia appearing as the primary indexed condition, and to 5 interventions — of which Total-Body Irradiation is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT00027820 reports 10 study locations spanning 9 distinct geographic areas — top geographies include Other, Arizona, California. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT00027820 about?

NCT00027820 is a clinical study titled "Total-Body Irradiation and Fludarabine Phosphate Followed by Donor Peripheral Blood Stem Cell Transplant in Treating Patients With Hematologic Malignancies or Kidney Cancer". This phase I/II trial studies whether a new kind of blood stem cell (bone marrow) transplant, that may be less toxic, is able to treat underlying blood cancer. Stem cells are "seed cells" necessary to make blood cells. Researchers want to see if using less radiation and less chemotherapy with new im...

What is the current status of trial NCT00027820?

This trial is currently completed. It is a Phase 1 study. The enrollment target is 106 participants. The study started on 2001-08. Estimated completion is 2004-09-05.

What conditions does trial NCT00027820 study?

This clinical trial studies the following conditions: Chronic Myelomonocytic Leukemia, Clear Cell Renal Cell Carcinoma, Adult Acute Myeloid Leukemia in Remission, Previously Treated Myelodysplastic Syndrome, Childhood Acute Lymphoblastic Leukemia in Remission. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT00027820?

The interventions under investigation include: Total-Body Irradiation (RADIATION), Fludarabine Phosphate (DRUG), Peripheral Blood Stem Cell Transplantation (PROCEDURE), Cyclosporine (DRUG), Nonmyeloablative Allogeneic Hematopoietic Stem Cell Transplantation (PROCEDURE). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT00027820?

This trial is sponsored by Fred Hutchinson Cancer Center, which has 319 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT00027820 being conducted?

This trial has 10 study locations across Arizona, California, Georgia, Oregon, Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial