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NCT05619289 · ClinicalTrials.gov registry record · Phase 2
Immune Mechanisms of Vitamin D to Reduce Chronic Pain After Burn
A Phase 2 study of Chronic Pain and Burn Injury, sponsored by University of North Carolina, Chapel Hill.
- Completed
- Registry status
- Phase 2
- Development phase
- 40
- Enrollment target
- 1
- Study location
NCT05619289: Completed Phase 2 study of Chronic Pain and Burn Injury, sponsored by University of North Carolina, Chapel Hill.
NCT05619289 is a Phase 2 study of Chronic Pain and Burn Injury that has completed, run by University of North Carolina, Chapel Hill. The registered enrollment target is 40 participants, below the 772-participant average among 301 other Chronic Pain trials with a reported enrollment target (95% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05619289, a Phase 2 study of Chronic Pain and Burn Injury, has completed, sponsored by University of North Carolina, Chapel Hill.
- COMPLETED
- Registry status
- Phase 2
- Development phase
- 40 participants
- Enrollment target
- 1
- Study location
Study Summary
The goal of this pilot clinical trial is to learn whether vitamin D is able to prevent chronic pain following burn injury and to determine what biological mechanisms are engaged by Vitamin D following burn injury. The main question\[s\] it aims to answer are: * Is the clinical trial protocol feasible? * Is Vitamin D administration following burn injury safe? * How does vitamin D cause changes in the immune system in the aftermath of burn injury? Following informed consent, participants will be asked to: * Take 6 capsules by mouth one time following burn injury (Vitamin D or Placebo) * Provide a blood sample at baseline and 6 weeks following injury * Fill out surveys daily while in the hospital, weekly through 6 weeks, and at 3 months and 6 months. Researchers will compare Vitamin D and placebo groups to see if there are differences in adverse effects (side effects), chronic pain, and profiles of immune cells from collected blood samples.
Primary Outcome
The proportion of patients who are able to follow-up at 6 weeks and complete a questionnaire will be calculated. To meet the primary outcome, follow-up will be \>80% at 6 weeks.
Conditions Studied
Interventions
- DRUG Placebo
- DRUG Ergocalciferol
Study Locations (1)
North Carolina
- University Of North Carolina - Chapel Hill
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 40 participants |
| Start Date | 2023-04-12 |
| Est. Completion | 2026-01-16 |
| Phase | Phase 2 |
What the finished NCT05619289 record still lists
NCT05619289 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 40 participants, a relatively small participant target, below the 772-participant average among 301 other Chronic Pain trials with a reported enrollment target (95% lower).
The record links to 2 conditions, with Chronic Pain appearing as the primary indexed condition, and to 2 interventions - of which Placebo is the first listed.
NCT05619289 reports a single indexed study location in North Carolina.
Frequently Asked Questions
What is clinical trial NCT05619289 about?
NCT05619289 is a clinical study titled "Immune Mechanisms of Vitamin D to Reduce Chronic Pain After Burn". The goal of this pilot clinical trial is to learn whether vitamin D is able to prevent chronic pain following burn injury and to determine what biological mechanisms are engaged by Vitamin D following burn injury. The main question\[s\] it aims to answer are: * Is the clinical trial protocol feasib...
What is the current status of trial NCT05619289?
This trial is currently completed. It is a Phase 2 study. The enrollment target is 40 participants. The study started on 2023-04-12. Estimated completion is 2026-01-16.
What conditions does trial NCT05619289 study?
This clinical trial studies the following conditions: Chronic Pain, Burn Injury.
What interventions are being tested in trial NCT05619289?
The interventions under investigation include: Placebo (DRUG), Ergocalciferol (DRUG).
Who is sponsoring clinical trial NCT05619289?
This trial is sponsored by University of North Carolina, Chapel Hill, which has 1,109 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05619289 being conducted?
This trial has 1 study location across North Carolina. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Chronic Pain
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05619289's enrollment target sits among peer trials
40 214th of 301 higher than 81 of 301 other Chronic Pain trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Chronic Pain trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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