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ClinicalTrials.gov 30 recruiting now early-phase tilt

Chronic Myelomonocytic Leukemia: early-phase trial registry

30 of 74 indexed Chronic Myelomonocytic Leukemia trials are currently recruiting, with more weight in Phase 1-2.

Corpus placement: #183 of 28,707 conditions by registered trial count.

74 US clinical trials · 30 currently recruiting · #183 of 28,707 conditions by registered trial count

Chronic Myelomonocytic Leukemia: 74 US clinical trials tracked, 30 recruiting.

Chronic Myelomonocytic Leukemia is the subject of 74 registered US clinical trials on ClinicalTrials.gov, 30 of them currently open to new participants. 3 are in Phase 3-4 (later-stage) and 70 in Phase 1-2 (earlier-stage). The most active sponsor is M.D. Anderson Cancer Center, running 15 of these trials.

Enrollment posture brief

Registry condition chronic-myelomonocytic-leukemia

OPEN 30 | RECR 41% | LATE 3 | EARLY 70 | RANK #183 | SPON 15

Nearest open-share peer: Pain, Acute (41% recruiting · 32 trials)

Chronic Kidney Diseases62.2%Anatomic Stage II Breast Can54.1%Chronic Myelomonocytic L (th…41%Anemia18.9%HIV Infection12.2%
Open-enrollment share among volume-matched conditions near Chronic Myelomonocytic Leukemia

Chronic Myelomonocytic Leukemia lists 30 open slots (41% of 74 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →

Key findings

What ClinicalTrials.gov does not surface for Chronic Myelomonocytic Leukemia on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.

  1. Chronic Myelomonocytic Leukemia recruits in line with its size-band peers.

    30 of 74 indexed trials (40.5%) are open to enrollment, against a 39.7% average across 762 conditions with 20-99 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.

  2. One sponsor concentrates Chronic Myelomonocytic Leukemia research.

    M.D. Anderson Cancer Center accounts for 15 of 74 trials (20.3%). 37 distinct sponsors appear on at least one study for this condition label.

  3. Most Chronic Myelomonocytic Leukemia trials plan to enrol fewer than 100 people.

    Median target enrolment is 52 among the 74 trials that report a genuine target (sentinel values excluded). 57 of those (77%) plan for fewer than 100 participants.

  4. Chronic Myelomonocytic Leukemia research is mostly interventional.

    73 interventional and 1 observational studies make up this index (98.6% interventional). Study type is sponsor-reported on ClinicalTrials.gov.

Phase 131Phase 239Phase 33

Open and recent trials

74 total, page 2 of 2

ACTIVE NOT RECRUITING Phase 2 20 participants

Adding Itacitinib to Cyclophosphamide and Tacrolimus for the Prevention of Graft Versus Host Disease in Patients Undergoing Hematopoietic Stem Cell Transplants

City of Hope Medical Center

NCT05364762

COMPLETED Phase 3 880 participants

Combination Chemotherapy With or Without Bone Marrow Transplantation in Treating Children With Acute Myelogenous Leukemia or Myelodysplastic Syndrome

National Cancer Institute (NCI)

NCT00002798

COMPLETED Phase 3 226 participants

Supersaturated Calcium Phosphate Rinse in Preventing Oral Mucositis in Young Patients Undergoing Autologous or Donor Stem Cell Transplant

Children's Oncology Group

NCT01305200

COMPLETED Phase 2 150 participants

Nivolumab and Azacitidine With or Without Ipilimumab in Treating Patients With Refractory/Relapsed or Newly Diagnosed Acute Myeloid Leukemia

M.D. Anderson Cancer Center

NCT02397720

COMPLETED Phase 2 128 participants

Study of Three Different Schedules of Low-Dose Decitabine in Myelodysplastic Syndrome (MDS)

M.D. Anderson Cancer Center

NCT00067808

COMPLETED Phase 1 106 participants

Total-Body Irradiation and Fludarabine Phosphate Followed by Donor Peripheral Blood Stem Cell Transplant in Treating Patients With Hematologic Malignancies or Kidney Cancer

Fred Hutchinson Cancer Center

NCT00027820

COMPLETED Phase 1 82 participants

Tagraxofusp (SL-401) in Participants With Chronic Myelomonocytic Leukemia (CMML) and Myelofibrosis (MF)

Stemline Therapeutics

NCT02268253

COMPLETED Phase 2 74 participants

CCI-779 in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, Myelodysplastic Syndromes, or Chronic Myelogenous Leukemia in Blastic Phase

National Cancer Institute (NCI)

NCT00084916

COMPLETED Phase 2 65 participants

Oral Clofarabine Study in Patients With Myelodysplastic Syndrome

M.D. Anderson Cancer Center

NCT00299156

COMPLETED Phase 1 65 participants

Tipifarnib in Treating Patients With Myelodysplastic Syndromes

National Cancer Institute (NCI)

NCT00005845

COMPLETED Phase 1 56 participants

Belinostat and Azacitidine in Treating Patients With Advanced Hematologic Cancers or Other Diseases

National Cancer Institute (NCI)

NCT00351975

COMPLETED Phase 2 52 participants

Phase II Study of Lenalidomide and Eltrombopag in Patients With Symptomatic Anemia

Albert Einstein College of Medicine

NCT01772420

COMPLETED 50 participants

Ascorbic Acid Levels in MDS, AML, and CMML Patients

Van Andel Research Institute

NCT03526666

COMPLETED Phase 2 50 participants

Chemotherapy in Treating Patients With Myelodysplastic Syndrome Before Donor Stem Cell Transplant

Fred Hutchinson Cancer Center

NCT01812252

COMPLETED Phase 2 50 participants

Clofarabine, Cytarabine, and Filgrastim in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia, Advanced Myelodysplastic Syndrome, and/or Advanced Myeloproliferative Neoplasm

University of Washington

NCT01101880

COMPLETED Phase 2 43 participants

Azacitidine in Treating Patients With Relapsed Myelodysplastic Syndrome, Chronic Myelomonocytic Leukemia, or Acute Myeloid Leukemia Who Have Undergone Stem Cell Transplant

Fred Hutchinson Cancer Center

NCT01083706

COMPLETED Phase 1 37 participants

Biological Therapy in Treating Patients With Advanced Myelodysplastic Syndrome, Acute or Chronic Myeloid Leukemia, or Acute Lymphoblastic Leukemia Who Are Undergoing Stem Cell Transplantation

Fred Hutchinson Cancer Center

NCT00052520

COMPLETED Phase 1 35 participants

Chemotherapy Plus Sargramostim in Treating Patients With Refractory Myeloid Cancer

National Cancer Institute (NCI)

NCT00012376

COMPLETED Phase 2 34 participants

A Study of Gleevec in Patients With Idiopathic Myelofibrosis or Chronic Myelomonocytic Leukemia (CMML)

Dana-Farber Cancer Institute

NCT00136409

COMPLETED Phase 1 23 participants

IDH2 Inhibition Using Enasidenib as Maintenance Therapy for IDH2-mutant Myeloid Neoplasms Following Allogeneic Stem Cell Transplantation

Massachusetts General Hospital

NCT03515512

COMPLETED Phase 2 22 participants

Total Body Irradiation +/- Total Lymphoid Irradiation & Anti-Thymocyte Globulin in Non-myeloablative Hematopoietic Cell Transplantation

Stanford University

NCT03734601

COMPLETED Phase 1 21 participants

Ibrutinib and Azacitidine for Treatment of Higher Risk Myelodysplastic Syndrome

Brian Jonas

NCT02553941

COMPLETED Phase 2 12 participants

A Study of E7820 in People With Bone Marrow (Myeloid) Cancers

Memorial Sloan Kettering Cancer Center

NCT05024994

COMPLETED Phase 2 11 participants

A Study of 5-Azacitidine (Vidaza®) in Patients With Chronic Myelomonocytic Leukemia

University of Utah

NCT01350947

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Phase Distribution

PhaseTrial count
Phase 1 31
Phase 2 39
Phase 3 3

Named interventions

Most-linked intervention names on Chronic Myelomonocytic Leukemia records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.

Azacitidine Drug
14 trials
Cyclophosphamide Drug
8 trials
Biospecimen Collection Procedure
6 trials
Venetoclax Drug
6 trials
laboratory biomarker analysis Other
5 trials
Laboratory Biomarker Analysis Other
5 trials
Peripheral Blood Stem Cell Transplantation Procedure
4 trials
Tacrolimus Drug
4 trials

US sites by state

Facility locations filed on Chronic Myelomonocytic Leukemia trials. A trial with sites in several states counts in each.

Texas 24 trials
California 23 trials
New York 16 trials
Ohio 14 trials
Massachusetts 13 trials
Florida 11 trials
Washington 10 trials
Maryland 10 trials

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

What to do with this Chronic Myelomonocytic Leukemia page

74 registered trials, 30 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.

Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Chronic Myelomonocytic Leukemia condition card totals 74 registered trials; most-linked intervention Azacitidine; top US site state Texas. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.