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ClinicalTrials.gov 30 recruiting now official registry

Chronic Myelomonocytic Leukemia clinical trials

30 of 74 indexed Chronic Myelomonocytic Leukemia trials are currently recruiting.

74 US clinical trials · 30 currently recruiting

Chronic Myelomonocytic Leukemia is the subject of 74 registered US clinical trials on ClinicalTrials.gov, 30 of them currently open to new participants. 3 are in Phase 3-4 (later-stage) and 70 in Phase 1-2 (earlier-stage). The most active sponsor is M.D. Anderson Cancer Center, running 15 of these trials.

The research picture

Chronic Myelomonocytic Leukemia has 74 registered US clinical trials, 30 of them open to new participants right now, about 41% of the total.

30
recruiting participants now
41%
of trials open to enrollment
3
in Phase 3–4 (later-stage)
15
top sponsor: M.D. Anderson Cancer Center
Phase 131Phase 239Phase 33

Active & Recent Trials

74 total, page 2 of 2

ACTIVE NOT RECRUITING Phase 2 20 participants

Adding Itacitinib to Cyclophosphamide and Tacrolimus for the Prevention of Graft Versus Host Disease in Patients Undergoing Hematopoietic Stem Cell Transplants

City of Hope Medical Center

NCT05364762

COMPLETED Phase 3 880 participants

Combination Chemotherapy With or Without Bone Marrow Transplantation in Treating Children With Acute Myelogenous Leukemia or Myelodysplastic Syndrome

National Cancer Institute (NCI)

NCT00002798

COMPLETED Phase 3 226 participants

Supersaturated Calcium Phosphate Rinse in Preventing Oral Mucositis in Young Patients Undergoing Autologous or Donor Stem Cell Transplant

Children's Oncology Group

NCT01305200

COMPLETED Phase 2 150 participants

Nivolumab and Azacitidine With or Without Ipilimumab in Treating Patients With Refractory/Relapsed or Newly Diagnosed Acute Myeloid Leukemia

M.D. Anderson Cancer Center

NCT02397720

COMPLETED Phase 2 128 participants

Study of Three Different Schedules of Low-Dose Decitabine in Myelodysplastic Syndrome (MDS)

M.D. Anderson Cancer Center

NCT00067808

COMPLETED Phase 1 106 participants

Total-Body Irradiation and Fludarabine Phosphate Followed by Donor Peripheral Blood Stem Cell Transplant in Treating Patients With Hematologic Malignancies or Kidney Cancer

Fred Hutchinson Cancer Center

NCT00027820

COMPLETED Phase 1 82 participants

Tagraxofusp (SL-401) in Participants With Chronic Myelomonocytic Leukemia (CMML) and Myelofibrosis (MF)

Stemline Therapeutics

NCT02268253

COMPLETED Phase 2 74 participants

CCI-779 in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, Myelodysplastic Syndromes, or Chronic Myelogenous Leukemia in Blastic Phase

National Cancer Institute (NCI)

NCT00084916

COMPLETED Phase 2 65 participants

Oral Clofarabine Study in Patients With Myelodysplastic Syndrome

M.D. Anderson Cancer Center

NCT00299156

COMPLETED Phase 1 65 participants

Tipifarnib in Treating Patients With Myelodysplastic Syndromes

National Cancer Institute (NCI)

NCT00005845

COMPLETED Phase 1 56 participants

Belinostat and Azacitidine in Treating Patients With Advanced Hematologic Cancers or Other Diseases

National Cancer Institute (NCI)

NCT00351975

COMPLETED Phase 2 52 participants

Phase II Study of Lenalidomide and Eltrombopag in Patients With Symptomatic Anemia

Albert Einstein College of Medicine

NCT01772420

COMPLETED 50 participants

Ascorbic Acid Levels in MDS, AML, and CMML Patients

Van Andel Research Institute

NCT03526666

COMPLETED Phase 2 50 participants

Chemotherapy in Treating Patients With Myelodysplastic Syndrome Before Donor Stem Cell Transplant

Fred Hutchinson Cancer Center

NCT01812252

COMPLETED Phase 2 50 participants

Clofarabine, Cytarabine, and Filgrastim in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia, Advanced Myelodysplastic Syndrome, and/or Advanced Myeloproliferative Neoplasm

University of Washington

NCT01101880

COMPLETED Phase 2 43 participants

Azacitidine in Treating Patients With Relapsed Myelodysplastic Syndrome, Chronic Myelomonocytic Leukemia, or Acute Myeloid Leukemia Who Have Undergone Stem Cell Transplant

Fred Hutchinson Cancer Center

NCT01083706

COMPLETED Phase 1 37 participants

Biological Therapy in Treating Patients With Advanced Myelodysplastic Syndrome, Acute or Chronic Myeloid Leukemia, or Acute Lymphoblastic Leukemia Who Are Undergoing Stem Cell Transplantation

Fred Hutchinson Cancer Center

NCT00052520

COMPLETED Phase 1 35 participants

Chemotherapy Plus Sargramostim in Treating Patients With Refractory Myeloid Cancer

National Cancer Institute (NCI)

NCT00012376

COMPLETED Phase 2 34 participants

A Study of Gleevec in Patients With Idiopathic Myelofibrosis or Chronic Myelomonocytic Leukemia (CMML)

Dana-Farber Cancer Institute

NCT00136409

COMPLETED Phase 1 23 participants

IDH2 Inhibition Using Enasidenib as Maintenance Therapy for IDH2-mutant Myeloid Neoplasms Following Allogeneic Stem Cell Transplantation

Massachusetts General Hospital

NCT03515512

COMPLETED Phase 2 22 participants

Total Body Irradiation +/- Total Lymphoid Irradiation & Anti-Thymocyte Globulin in Non-myeloablative Hematopoietic Cell Transplantation

Stanford University

NCT03734601

COMPLETED Phase 1 21 participants

Ibrutinib and Azacitidine for Treatment of Higher Risk Myelodysplastic Syndrome

Brian Jonas

NCT02553941

COMPLETED Phase 2 12 participants

A Study of E7820 in People With Bone Marrow (Myeloid) Cancers

Memorial Sloan Kettering Cancer Center

NCT05024994

COMPLETED Phase 2 11 participants

A Study of 5-Azacitidine (Vidaza®) in Patients With Chronic Myelomonocytic Leukemia

University of Utah

NCT01350947

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Phase Distribution

PhaseTrial count
Phase 1 31
Phase 2 39
Phase 3 3

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Chronic Myelomonocytic Leukemia Trial Landscape

74 indexed Chronic Myelomonocytic Leukemia studies · 30 recruiting (41%).

Phase mix: 3 late (III/IV) vs 70 early (I/II).

Top sponsor: M.D. Anderson Cancer Center (15 trials), 9 others listed. 24 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Chronic Myelomonocytic Leukemia?

PlainTrial tracks 74 US clinical trials for Chronic Myelomonocytic Leukemia, of which 30 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Chronic Myelomonocytic Leukemia?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.