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NCT06950034 · ClinicalTrials.gov registry record · Phase 1
A Phase 1 Study of STX-0712 in Patients With Advanced Hematological Malignancies (CMML and AML)
A Phase 1 study of Acute Myeloid Leukemia and Chronic Myelomonocytic Leukemia, sponsored by Solu Therapeutics.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 105
- Enrollment target
- 7
- Study locations
NCT06950034: Recruiting Phase 1 study of Acute Myeloid Leukemia and Chronic Myelomonocytic Leukemia, sponsored by Solu Therapeutics.
NCT06950034 is a Phase 1 study of Acute Myeloid Leukemia and Chronic Myelomonocytic Leukemia that is actively recruiting participants, run by Solu Therapeutics. The registered enrollment target is 105 participants, roughly in line with the 115-participant average among 306 other Acute Myeloid Leukemia trials with a reported enrollment target. The trial reports 7 study locations across 7 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06950034, a Phase 1 study of Acute Myeloid Leukemia and Chronic Myelomonocytic Leukemia, is actively recruiting participants, sponsored by Solu Therapeutics.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 105 participants
- Enrollment target
- 7
- Study locations
Study Summary
This is a first-in-human, multicenter, open-label, phase 1 study to evaluate the safety, PK, PD and preliminary efficacy of STX-0712 in patients with advanced CMML and AML for whom there are no further treatment options known to confer clinical benefit.
Primary Outcome
Incidence of dose-limiting toxicity (DLT) events during the DLT monitoring period
Conditions Studied
Interventions
- BIOLOGICAL STX-0712
Study Locations (7)
California
- Stanford University - Stanford
Florida
- Moffitt - Tampa
Massachusetts
- DFCI - Boston
Minnesota
- Mayo Clinic - Rochester
Oregon
- OHSU - Portland
Tennessee
- Vanderbilt University - Nashville
Texas
- MD Anderson Cancer Center - Houston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 105 participants |
| Start Date | 2025-03-13 |
| Est. Completion | 2027-06-30 |
| Phase | Phase 1 |
What NCT06950034 shows while recruiting
NCT06950034 is an interventional study that assigns participants to a tested intervention. The registered 105 participants enrollment target is mid-sized for trials with a published cap, roughly in line with the 115-participant average among 306 other Acute Myeloid Leukemia trials with a reported enrollment target.
The record links to 10 conditions, with Acute Myeloid Leukemia appearing as the primary indexed condition, and to 1 intervention - of which STX-0712 is the first listed.
NCT06950034 lists 7 locations in 7 states (California, Florida, Massachusetts).
Frequently Asked Questions
What is clinical trial NCT06950034 about?
NCT06950034 is a clinical study titled "A Phase 1 Study of STX-0712 in Patients With Advanced Hematological Malignancies (CMML and AML)". This is a first-in-human, multicenter, open-label, phase 1 study to evaluate the safety, PK, PD and preliminary efficacy of STX-0712 in patients with advanced CMML and AML for whom there are no further treatment options known to confer clinical benefit.
What is the current status of trial NCT06950034?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 105 participants. The study started on 2025-03-13. Estimated completion is 2027-06-30.
What conditions does trial NCT06950034 study?
This clinical trial studies the following conditions: Acute Myeloid Leukemia, Chronic Myelomonocytic Leukemia, Acute Myeloid Leukemia (AML), Acute Myeloid Leukemia Post Cytotoxic Therapy, Refractory Chronic Myelomonocytic Leukemia.
What interventions are being tested in trial NCT06950034?
The interventions under investigation include: STX-0712 (BIOLOGICAL).
Who is sponsoring clinical trial NCT06950034?
This trial is sponsored by Solu Therapeutics, which has 1 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06950034 being conducted?
This trial has 7 study locations across California, Florida, Massachusetts, Minnesota, Oregon. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT06950034's enrollment target sits among peer trials
105 75th of 306 higher than 231 of 306 other Acute Myeloid Leukemia trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Acute Myeloid Leukemia trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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