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COMPLETED Phase 2

Study of Talabostat and Rituximab in Advanced Chronic Lymphocytic Leukemia (CLL)

NCT00086203 · View on ClinicalTrials.gov ↗

Study Summary

The objective of this study is to assess the efficacy and safety of talabostat and rituximab in patients with advanced CLL who failed to respond, or have progressed following a prior response, to a fludarabine regimen.

Interventions

  • DRUG Rituximab
  • DRUG Talabostat mesylate (PT-100) tablets

Study Locations (19)

New York

  • Queens Medical Associates, PC — Fresh Meadows
  • Long Island Jewish Medical Center — New Hyde Park
  • NYU Medical Center — New York
  • James P. Wilmot Cancer Center/University of Rochester — Rochester

Florida

  • Ocala Oncology Center — Ocala
  • Gulfcoast Oncology Associates — St. Petersburg

North Carolina

  • Raleigh Hematology/Oncology Clinic — Cary
  • Wake Forest University Health Sciences — Winston-Salem

Oklahoma

  • Cancer Care Associates/Oklahoma City — Oklahoma City
  • Cancer Care Associates--Tulsa — Tulsa

Texas

  • Texas Cancer Center/Abilene — Abilene
  • MD Anderson Cancer Center — Houston

Arkansas

  • University of Arkansas for Medical Science — Little Rock

Indiana

  • Indiana Oncology/Hematology Consultants — Indianapolis

Massachusetts

  • Dana Farber Cancer Institute — Boston

Trial Details

FieldValue
Est. Completion 2007-09
Phase Phase 2

Sponsor

Point Therapeutics

2 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT00086203

The ClinicalTrials.gov registry entry for NCT00086203 describes a study currently listed as completed. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. An enrollment target was not published in the registry record, which is common for early-stage or observational entries. The listed sponsor is Point Therapeutics, which has 2 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Chronic Lymphocytic Leukemia appearing as the primary indexed condition, and to 2 interventions — of which Rituximab is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT00086203 reports 19 study locations spanning 12 distinct geographic areas — top geographies include New York, Florida, North Carolina. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT00086203 about?

NCT00086203 is a clinical study titled "Study of Talabostat and Rituximab in Advanced Chronic Lymphocytic Leukemia (CLL)". The objective of this study is to assess the efficacy and safety of talabostat and rituximab in patients with advanced CLL who failed to respond, or have progressed following a prior response, to a fludarabine regimen.

What is the current status of trial NCT00086203?

This trial is currently completed. It is a Phase 2 study. Estimated completion is 2007-09.

What conditions does trial NCT00086203 study?

This clinical trial studies the following conditions: Chronic Lymphocytic Leukemia. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT00086203?

The interventions under investigation include: Rituximab (DRUG), Talabostat mesylate (PT-100) tablets (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT00086203?

This trial is sponsored by Point Therapeutics, which has 2 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT00086203 being conducted?

This trial has 19 study locations across Arkansas, Florida, Indiana, Massachusetts, Montana. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial