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ACTIVE NOT RECRUITING Phase 2

A Study of Belzutifan (MK-6482) in Participants With Advanced Renal Cell Carcinoma (MK-6482-013)

NCT04489771 · View on ClinicalTrials.gov ↗

Study Summary

This study will compare the efficacy and safety of two doses of belzutifan in participants with advanced renal cell carcinoma (RCC) with clear cell component after prior therapy. The primary hypothesis is that the higher dose of belzutifan is superior to the standard dose in terms of objective response rate (ORR).

Conditions Studied

Interventions

  • DRUG Belzutifan

Study Locations (20)

Nebraska

  • Cancer Partners of Nebraska ( Site 0003) — Lincoln
  • Oncology Hematology West, PC dba Nebraska Cancer Specialists ( Site 0012) — Omaha

New York

  • New York Oncology Hematology P.C ( Site 0028) — Albany
  • Roswell Park Cancer Institute ( Site 0038) — Buffalo

Tennessee

  • UT West Cancer Center ( Site 0032) — Germantown
  • Urology Associates ( Site 0015) — Nashville

Texas

  • University of Texas Southwestern Medical Center at Dallas ( Site 0004) — Dallas
  • Baylor Scott & White Medical Center - Temple ( Site 0013) — Temple

Virginia

  • Inova Schar Cancer Institute ( Site 0001) — Fairfax
  • Blue Ridge Cancer Care - Roanoke ( Site 0017) — Roanoke

District of Columbia

  • Georgetown University Medical Center ( Site 0002) — Washington D.C.

Florida

  • Univ of Miami- Sylvester Comprehensive Cancer Center ( Site 0023) — Miami

Kentucky

  • Norton Cancer Institute - St. Matthews ( Site 0025) — Louisville

Trial Details

FieldValue
Enrollment Target 154 participants
Start Date 2020-09-13
Est. Completion 2026-10-04
Phase Phase 2

Sponsor

Merck Sharp & Dohme

741 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT04489771

The ClinicalTrials.gov registry entry for NCT04489771 describes a study currently listed as active not recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 154 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Merck Sharp & Dohme, which has 741 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Carcinoma, Renal Cell appearing as the primary indexed condition, and to 1 intervention — of which Belzutifan is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT04489771 reports 20 study locations spanning 15 distinct geographic areas — top geographies include Nebraska, New York, Tennessee. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT04489771 about?

NCT04489771 is a clinical study titled "A Study of Belzutifan (MK-6482) in Participants With Advanced Renal Cell Carcinoma (MK-6482-013)". This study will compare the efficacy and safety of two doses of belzutifan in participants with advanced renal cell carcinoma (RCC) with clear cell component after prior therapy. The primary hypothesis is that the higher dose of belzutifan is superior to the standard dose in terms of objective resp...

What is the current status of trial NCT04489771?

This trial is currently active not recruiting. It is a Phase 2 study. The enrollment target is 154 participants. The study started on 2020-09-13. Estimated completion is 2026-10-04.

What conditions does trial NCT04489771 study?

This clinical trial studies the following conditions: Carcinoma, Renal Cell. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT04489771?

The interventions under investigation include: Belzutifan (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT04489771?

This trial is sponsored by Merck Sharp & Dohme, which has 741 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT04489771 being conducted?

This trial has 20 study locations across District of Columbia, Florida, Kentucky, Maryland, Nebraska. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial