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COMPLETED Phase 2

GW786034 In Subjects With Locally Recurrent Or Metastatic Clear Cell Renal Cell Carcinoma

NCT00244764 · View on ClinicalTrials.gov ↗

Study Summary

Phase II, multi-center, two-stage study utilising a randomised discontinuation design to evaluate the safety and efficacy of GW786034 (pazopanib) in adult subjects with locally recurrent or metastatic clear-cell Renal Cell Carcinoma (RCC). After the interim analysis, the design was changed to an open label, single arm study with all subjects receiving pazopanib.

Conditions Studied

Interventions

  • DRUG Placebo
  • DRUG GW786034

Study Locations (20)

California

  • GSK Investigational Site — Duarte
  • GSK Investigational Site — Los Angeles
  • GSK Investigational Site — Orange
  • GSK Investigational Site — San Francisco

Victoria

  • GSK Investigational Site — East Melbourne
  • GSK Investigational Site — Footscay
  • GSK Investigational Site — Heidelberg
  • GSK Investigational Site — Parkville

New South Wales

  • GSK Investigational Site — Camperdown
  • GSK Investigational Site — Kogarah
  • GSK Investigational Site — Randwick

Ohio

  • GSK Investigational Site — Cleveland
  • GSK Investigational Site — Cleveland

Colorado

  • GSK Investigational Site — Aurora

Georgia

  • GSK Investigational Site — Tucker

Indiana

  • GSK Investigational Site — Indianapolis

New York

  • GSK Investigational Site — New York

Trial Details

FieldValue
Enrollment Target 225 participants
Start Date 2005-10
Est. Completion 2013-09
Phase Phase 2

Sponsor

GlaxoSmithKline

558 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT00244764

The ClinicalTrials.gov registry entry for NCT00244764 describes a study currently listed as completed. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 225 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is GlaxoSmithKline, which has 558 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Carcinoma, Renal Cell appearing as the primary indexed condition, and to 2 interventions — of which Placebo is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT00244764 reports 20 study locations spanning 11 distinct geographic areas — top geographies include California, Victoria, New South Wales. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT00244764 about?

NCT00244764 is a clinical study titled "GW786034 In Subjects With Locally Recurrent Or Metastatic Clear Cell Renal Cell Carcinoma". Phase II, multi-center, two-stage study utilising a randomised discontinuation design to evaluate the safety and efficacy of GW786034 (pazopanib) in adult subjects with locally recurrent or metastatic clear-cell Renal Cell Carcinoma (RCC). After the interim analysis, the design was changed to an ope...

What is the current status of trial NCT00244764?

This trial is currently completed. It is a Phase 2 study. The enrollment target is 225 participants. The study started on 2005-10. Estimated completion is 2013-09.

What conditions does trial NCT00244764 study?

This clinical trial studies the following conditions: Carcinoma, Renal Cell. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT00244764?

The interventions under investigation include: Placebo (DRUG), GW786034 (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT00244764?

This trial is sponsored by GlaxoSmithKline, which has 558 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT00244764 being conducted?

This trial has 20 study locations across California, Colorado, Georgia, Indiana, New York. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial