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Cachexia clinical trials
Every US clinical trial registered for Cachexia — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.
17 US clinical trials · 3 currently recruiting
The research picture
Cachexia has 17 registered US clinical trials, 3 of them open to new participants right now — about 18% of the total.
- 3
- recruiting participants now
- 18%
- of trials open to enrollment
- 8
- in Phase 3–4 (later-stage)
- 3
- top sponsor: Bristol-Myers Squibb
Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.
Active & Recent Trials
A Study to Learn About the Medicine Ponsegromab in Adults With Cancer of the Pancreas Which Has Spread and Caused Significant Body Weight Loss and Fatigue
Pfizer
NCT06989437
Assoc. of Genomic Polymorphisms With Cancer Cachexia in Subjects With Panc Adenocarcinoma
Wake Forest University Health Sciences
NCT05376592
A Dose Escalation Study of AV-380 in Cancer Patients With Cachexia
AVEO Pharmaceuticals
NCT05865535
Ruxolitinib for Cancer Cachexia
Tu Dan
NCT04906746
Safety and Efficacy of Anamorelin HCl in Patients With Non-Small Cell Lung Cancer-Cachexia (ROMANA 2)
Helsinn Therapeutics (U.S.)
NCT01387282
Comparison of Nutritional Supplements in Preventing Weight Loss in Patients With Cancer
Radiation Therapy Oncology Group
NCT00053053
Multimodal Intervention for Cachexia in Advanced Cancer Patients Undergoing Chemotherapy
Norwegian University of Science and Technology
NCT02330926
Study to Evaluate the Safety and Efficacy of 13 Weeks of the Selective Androgen Receptor Modulator (SARM) GSK2881078 in Chronic Obstructive Pulmonary Disease (COPD)
GlaxoSmithKline
NCT03359473
Docetaxel With or Without Infliximab in Treating Weight Loss, Loss of Appetite, and Fatigue in Patients With Unresectable Non-Small Cell Lung Cancer (Infliximab Treatment Discontinued Effective 10/05/05)
Alliance for Clinical Trials in Oncology
NCT00040885
Phase II Randomized Study of Physiologic Testosterone Replacement in Premenopausal, HIV-Positive Women
Charles Drew University of Medicine and Science
NCT00004400
The Safety and Effectiveness of Megace in HIV-Infected Women
Bristol-Myers Squibb
NCT00002345
Megestrol in Treating Patients Who Are Undergoing Radiation Therapy for Lung Cancer
Wake Forest University Health Sciences
NCT00031785
Study to Compare the Effects of Repeated Doses of an Investigational New Drug and a Placebo on Appetite in Advanced Cancer and Anorexia
Pfizer
NCT04803305
Bovine Lactoferrin Supplement in Improving Taste in Patients With Cancer Receiving Chemotherapy
Wake Forest University Health Sciences
NCT01941810
A Study Comparing Megestrol Acetate at 800 mg/Day, and Placebo in AIDS Patients With Anorexia and Cachexia
Bristol-Myers Squibb
NCT00002067
A Study of Different Doses of Megestrol Acetate in Patients With AIDS Who Have Anorexia and Malnutrition
Bristol-Myers Squibb
NCT00002300
Etanercept in Treating Cancer-Related Cachexia and Anorexia in Patients With Advanced Cancer
Mayo Clinic
NCT00046904
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 3 |
| Phase 2 | 4 |
| Phase 3 | 7 |
| Phase 4 | 1 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Cachexia Trial Landscape
ClinicalTrials.gov lists 17 US studies indexed under Cachexia, and 3 of those are currently open to recruitment — roughly 18% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
The phase distribution for Cachexia shows 8 late-stage studies (Phase 3 and Phase 4 combined) alongside 7 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
Top sponsor activity for Cachexia is led by Bristol-Myers Squibb with 3 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 17 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Cachexia?
PlainTrial tracks 17 US clinical trials for Cachexia, of which 3 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Cachexia?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology — how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.