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RECRUITING Phase 2

A Study to Learn About the Medicine Ponsegromab in Adults With Cancer of the Pancreas Which Has Spread and Caused Significant Body Weight Loss and Fatigue

NCT06989437 · View on ClinicalTrials.gov ↗

Study Summary

Study to investigate the efficacy, safety and tolerability of systemic chemotherapy plus ponsegromab versus systemic chemotherapy plus placebo for the first-line treatment in adult participants with cachexia and metastatic pancreatic ductal adenocardinoma.

Interventions

  • DRUG placebo
  • DRUG ponsegromab

Study Locations (20)

Arkansas

  • Central Arkansas Radiation Therapy Institute, dba CARTI — Bryant
  • Central Arkansas Radiation Therapy Institute, dba CARTI — Conway
  • CARTI Cancer Center — Little Rock
  • Central Arkansas Radiation Therapy Institute, dba CARTI — North Little Rock
  • Central Arkansas Radiation Therapy Institute, dba CARTI — Pine Bluff

Hawaii

  • Invision, LLC — Honolulu
  • University of Hawaii Cancer Center — Honolulu
  • Cardiology Associates, Inc — ‘Aiea

Nevada

  • Renown Health Medical Oncology — Reno
  • Renown Office of Clinical Research — Reno
  • Renown Regional Medical Center — Reno

Oregon

  • OHSU Center for Health & Healing 1 — Portland
  • Oregon Health and Science University — Portland
  • OSHU Center for Health and Healing 2 — Portland

California

  • Cedars-Sinai Cancer at Cedars-Sinai Medical Center — Los Angeles
  • Providence Medical Foundation — Santa Rosa

Illinois

  • Hope and Healing Cancer Services — Hinsdale
  • Hope and Healing Cancer Services New Lenox — New Lenox

Washington

  • Virginia Mason Medical Center — Seattle

New South Wales

  • Shoalhaven District Memorial Hospital — Nowra

Trial Details

FieldValue
Enrollment Target 982 participants
Start Date 2025-10-03
Est. Completion 2029-12-10
Phase Phase 2

Sponsor

Pfizer

769 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06989437

The ClinicalTrials.gov registry entry for NCT06989437 describes a study currently listed as recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 982 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Pfizer, which has 769 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 2 conditions, with Metastatic Pancreatic Ductal Adenocarcinoma appearing as the primary indexed condition, and to 2 interventions — of which placebo is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT06989437 reports 20 study locations spanning 8 distinct geographic areas — top geographies include Arkansas, Hawaii, Nevada. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT06989437 about?

NCT06989437 is a clinical study titled "A Study to Learn About the Medicine Ponsegromab in Adults With Cancer of the Pancreas Which Has Spread and Caused Significant Body Weight Loss and Fatigue". Study to investigate the efficacy, safety and tolerability of systemic chemotherapy plus ponsegromab versus systemic chemotherapy plus placebo for the first-line treatment in adult participants with cachexia and metastatic pancreatic ductal adenocardinoma.

What is the current status of trial NCT06989437?

This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 982 participants. The study started on 2025-10-03. Estimated completion is 2029-12-10.

What conditions does trial NCT06989437 study?

This clinical trial studies the following conditions: Metastatic Pancreatic Ductal Adenocarcinoma, Cachexia. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT06989437?

The interventions under investigation include: placebo (DRUG), ponsegromab (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT06989437?

This trial is sponsored by Pfizer, which has 769 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT06989437 being conducted?

This trial has 20 study locations across Arkansas, California, Hawaii, Illinois, Nevada. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial