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Avascular Necrosis clinical trials
Every US clinical trial registered for Avascular Necrosis — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.
25 US clinical trials · 4 currently recruiting
The research picture
Avascular Necrosis has 25 registered US clinical trials, 4 of them open to new participants right now — about 16% of the total.
- 4
- recruiting participants now
- 16%
- of trials open to enrollment
- 1
- in Phase 3–4 (later-stage)
- 9
- top sponsor: Zimmer Biomet
Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.
Active & Recent Trials
Physica System Total Knee Replacement Registry Study
Limacorporate S.p.a
NCT03048201
Persona OsseoTi Keel Compatibility Study (Total Knee Arthroplasty)
Zimmer Biomet
NCT05787821
Perform Humeral System Study
Stryker Trauma and Extremities
NCT05067543
Alendronate for Osteonecrosis in Adults With Sickle Cell Disease
University of California, Davis
NCT06016634
Persona Partial Knee Clinical Outcomes Study
Zimmer Biomet
NCT03034811
Insignia™ Hip Stem Outcomes Study
Stryker Orthopaedics
NCT05144191
Cemented vs Cementless Persona Keel RCT
Zimmer Biomet
NCT05630053
Persona Ti-Nidium Post-Market Clinical Follow-up
Zimmer Biomet
NCT04817969
Outcomes Study of the Trabecular Metal (TM) Reverse Shoulder System
Zimmer Biomet
NCT01480440
Zimmer Continuum Metal on Polyethylene (MoP) PostMarket Clinical Followup (PMCF) Study
Zimmer Biomet
NCT01307384
Database Retrieval for the Comprehensive Shoulder
Zimmer Biomet
NCT03409718
Post Market Clinical Follow-Up Study for EVOLUTION® BIOFOAM® Tibia and EVOLUTION® CS/CR Porous Femur
MicroPort Orthopedics
NCT04301622
A Multi-Centre Study in Patients Undergoing Total Hip Arthroplasty With the Smith+Nephew CATALYSTEM™ Primary Hip System
Smith & Nephew
NCT06564636
Post Market Clinical Follow-Up Study for EVOLUTION® NitrX™ Keeled Tibia and EVOLUTION® NitrX™ CS/CR Femur With Cruciate Sacrificing Insert
MicroPort Orthopedics
NCT07391592
Pyrocarbon Clinical Follow-up Study
Stryker Trauma and Extremities
NCT05049993
Sickle Cell Disease (SCD) Bone Pain Study
University of California, Davis
NCT05283148
The Use of Genex in the Management of Early-Stage Osteonecrosis of the Femoral Head
The Cleveland Clinic
NCT05706909
Clinical Study Evaluating an Acetabular Cup System After Total Hip Replacement
DePuy Orthopaedics
NCT00306930
A Clinical Investigation of the Oxford® Meniscal Unicompartmental Knee System
Biomet Orthopedics
NCT00578994
Post-PMA Approval Study: 10 Year Follow-Up IDE Subjects
Corin
NCT00721994
A Clinical Investigation of ArComXL® Polyethylene in Total Hip Replacement
Zimmer Biomet
NCT00698152
Opioid-Free Shoulder Arthroplasty
OrthoCarolina Research Institute
NCT03540030
Continuum™ Metal Bearing System in Total Hip Arthroplasty
Zimmer Biomet
NCT03382652
Ceramic On Ceramic (COC) 36mm PAS IDE Rollover Subjects; Ceramic Acetabular Bearing With Ceramic Femoral Head in Total Hip Replacement
DePuy Orthopaedics
NCT02096198
Acetabular Shell Positioning Using Patient Specific Instruments
The Cleveland Clinic
NCT01791738
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 1 |
| Phase 2 | 1 |
| Phase 4 | 1 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Avascular Necrosis Trial Landscape
ClinicalTrials.gov lists 25 US studies indexed under Avascular Necrosis, and 4 of those are currently open to recruitment — roughly 16% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
The phase distribution for Avascular Necrosis shows 1 late-stage studies (Phase 3 and Phase 4 combined) alongside 2 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
Top sponsor activity for Avascular Necrosis is led by Zimmer Biomet with 9 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 25 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Avascular Necrosis?
PlainTrial tracks 25 US clinical trials for Avascular Necrosis, of which 4 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Avascular Necrosis?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology — how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.