Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.

ClinicalTrials.gov 4 recruiting now official registry

Avascular Necrosis clinical trials

Every US clinical trial registered for Avascular Necrosis — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.

25 US clinical trials · 4 currently recruiting

The research picture

Avascular Necrosis has 25 registered US clinical trials, 4 of them open to new participants right now — about 16% of the total.

4
recruiting participants now
16%
of trials open to enrollment
1
in Phase 3–4 (later-stage)
9
top sponsor: Zimmer Biomet

Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.

Active & Recent Trials

RECRUITING NA 800 participants

Physica System Total Knee Replacement Registry Study

Limacorporate S.p.a

NCT03048201

RECRUITING 760 participants

Persona OsseoTi Keel Compatibility Study (Total Knee Arthroplasty)

Zimmer Biomet

NCT05787821

RECRUITING 300 participants

Perform Humeral System Study

Stryker Trauma and Extremities

NCT05067543

RECRUITING Phase 2 30 participants

Alendronate for Osteonecrosis in Adults With Sickle Cell Disease

University of California, Davis

NCT06016634

ACTIVE NOT RECRUITING NA 643 participants

Persona Partial Knee Clinical Outcomes Study

Zimmer Biomet

NCT03034811

ACTIVE NOT RECRUITING NA 313 participants

Insignia™ Hip Stem Outcomes Study

Stryker Orthopaedics

NCT05144191

ACTIVE NOT RECRUITING NA 300 participants

Cemented vs Cementless Persona Keel RCT

Zimmer Biomet

NCT05630053

ACTIVE NOT RECRUITING NA 240 participants

Persona Ti-Nidium Post-Market Clinical Follow-up

Zimmer Biomet

NCT04817969

ACTIVE NOT RECRUITING 200 participants

Outcomes Study of the Trabecular Metal (TM) Reverse Shoulder System

Zimmer Biomet

NCT01480440

ACTIVE NOT RECRUITING 165 participants

Zimmer Continuum Metal on Polyethylene (MoP) PostMarket Clinical Followup (PMCF) Study

Zimmer Biomet

NCT01307384

ACTIVE NOT RECRUITING 160 participants

Database Retrieval for the Comprehensive Shoulder

Zimmer Biomet

NCT03409718

ACTIVE NOT RECRUITING 150 participants

Post Market Clinical Follow-Up Study for EVOLUTION® BIOFOAM® Tibia and EVOLUTION® CS/CR Porous Femur

MicroPort Orthopedics

NCT04301622

ACTIVE NOT RECRUITING 119 participants

A Multi-Centre Study in Patients Undergoing Total Hip Arthroplasty With the Smith+Nephew CATALYSTEM™ Primary Hip System

Smith & Nephew

NCT06564636

ACTIVE NOT RECRUITING 100 participants

Post Market Clinical Follow-Up Study for EVOLUTION® NitrX™ Keeled Tibia and EVOLUTION® NitrX™ CS/CR Femur With Cruciate Sacrificing Insert

MicroPort Orthopedics

NCT07391592

ACTIVE NOT RECRUITING 76 participants

Pyrocarbon Clinical Follow-up Study

Stryker Trauma and Extremities

NCT05049993

ACTIVE NOT RECRUITING NA 53 participants

Sickle Cell Disease (SCD) Bone Pain Study

University of California, Davis

NCT05283148

ACTIVE NOT RECRUITING 22 participants

The Use of Genex in the Management of Early-Stage Osteonecrosis of the Femoral Head

The Cleveland Clinic

NCT05706909

COMPLETED NA 1,593 participants

Clinical Study Evaluating an Acetabular Cup System After Total Hip Replacement

DePuy Orthopaedics

NCT00306930

COMPLETED 388 participants

A Clinical Investigation of the Oxford® Meniscal Unicompartmental Knee System

Biomet Orthopedics

NCT00578994

COMPLETED 231 participants

Post-PMA Approval Study: 10 Year Follow-Up IDE Subjects

Corin

NCT00721994

COMPLETED 149 participants

A Clinical Investigation of ArComXL® Polyethylene in Total Hip Replacement

Zimmer Biomet

NCT00698152

COMPLETED Phase 4 86 participants

Opioid-Free Shoulder Arthroplasty

OrthoCarolina Research Institute

NCT03540030

COMPLETED 83 participants

Continuum™ Metal Bearing System in Total Hip Arthroplasty

Zimmer Biomet

NCT03382652

COMPLETED 81 participants

Ceramic On Ceramic (COC) 36mm PAS IDE Rollover Subjects; Ceramic Acetabular Bearing With Ceramic Femoral Head in Total Hip Replacement

DePuy Orthopaedics

NCT02096198

COMPLETED Phase 1 36 participants

Acetabular Shell Positioning Using Patient Specific Instruments

The Cleveland Clinic

NCT01791738

Phase Distribution

PhaseTrial count
Phase 1 1
Phase 2 1
Phase 4 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Avascular Necrosis Trial Landscape

ClinicalTrials.gov lists 25 US studies indexed under Avascular Necrosis, and 4 of those are currently open to recruitment — roughly 16% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Avascular Necrosis shows 1 late-stage studies (Phase 3 and Phase 4 combined) alongside 2 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Avascular Necrosis is led by Zimmer Biomet with 9 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 25 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Avascular Necrosis?

PlainTrial tracks 25 US clinical trials for Avascular Necrosis, of which 4 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Avascular Necrosis?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →