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Avascular Necrosis: early-phase trial registry
4 of 25 indexed Avascular Necrosis trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #652 of 28,707 conditions by registered trial count.
25 US clinical trials · 4 currently recruiting · #652 of 28,707 conditions by registered trial count
Avascular Necrosis: 25 US clinical trials tracked, 4 recruiting.
Avascular Necrosis is the subject of 25 registered US clinical trials on ClinicalTrials.gov, 4 of them currently open to new participants. 1 are in Phase 3-4 (later-stage) and 2 in Phase 1-2 (earlier-stage). The most active sponsor is Zimmer Biomet, running 9 of these trials.
Enrollment posture brief
Registry condition avascular-necrosis
OPEN 4 | RECR 16% | LATE 1 | EARLY 2 | RANK #652 | SPON 9
Volume-matched condition peers
Nearest open-share peer: Atrial Flutter (16% recruiting · 25 trials)
Avascular Necrosis lists 4 open slots (16% of 25 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Avascular Necrosis on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Avascular Necrosis is recruiting below its size-band peers.
4 of 25 indexed trials (16%) are open to enrollment, against a 39.7% average across 762 conditions with 20-99 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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One sponsor concentrates Avascular Necrosis research.
Zimmer Biomet accounts for 9 of 25 trials (36%). 12 distinct sponsors appear on at least one study for this condition label.
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Typical Avascular Necrosis enrolment sits around 160 participants.
Median target enrolment is 160 among the 25 trials that report a genuine target (sentinel values excluded). 8 of those (32%) plan for fewer than 100 participants.
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Avascular Necrosis research leans observational.
10 interventional and 15 observational studies make up this index (40% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
25 total, page 1 of 1
Physica System Total Knee Replacement Registry Study
Limacorporate S.p.a
NCT03048201
Persona OsseoTi Keel Compatibility Study (Total Knee Arthroplasty)
Zimmer Biomet
NCT05787821
Perform Humeral System Study
Stryker Trauma and Extremities
NCT05067543
Alendronate for Osteonecrosis in Adults With Sickle Cell Disease
University of California, Davis
NCT06016634
Persona Partial Knee Clinical Outcomes Study
Zimmer Biomet
NCT03034811
Insignia™ Hip Stem Outcomes Study
Stryker Orthopaedics
NCT05144191
Cemented vs Cementless Persona Keel RCT
Zimmer Biomet
NCT05630053
Persona Ti-Nidium Post-Market Clinical Follow-up
Zimmer Biomet
NCT04817969
Outcomes Study of the Trabecular Metal (TM) Reverse Shoulder System
Zimmer Biomet
NCT01480440
Zimmer Continuum Metal on Polyethylene (MoP) PostMarket Clinical Followup (PMCF) Study
Zimmer Biomet
NCT01307384
Database Retrieval for the Comprehensive Shoulder
Zimmer Biomet
NCT03409718
Post Market Clinical Follow-Up Study for EVOLUTION® BIOFOAM® Tibia and EVOLUTION® CS/CR Porous Femur
MicroPort Orthopedics
NCT04301622
A Multi-Centre Study in Patients Undergoing Total Hip Arthroplasty With the Smith+Nephew CATALYSTEM™ Primary Hip System
Smith & Nephew
NCT06564636
Post Market Clinical Follow-Up Study for EVOLUTION® NitrX™ Keeled Tibia and EVOLUTION® NitrX™ CS/CR Femur With Cruciate Sacrificing Insert
MicroPort Orthopedics
NCT07391592
Pyrocarbon Clinical Follow-up Study
Stryker Trauma and Extremities
NCT05049993
Sickle Cell Disease (SCD) Bone Pain Study
University of California, Davis
NCT05283148
The Use of Genex in the Management of Early-Stage Osteonecrosis of the Femoral Head
The Cleveland Clinic
NCT05706909
Clinical Study Evaluating an Acetabular Cup System After Total Hip Replacement
DePuy Orthopaedics
NCT00306930
A Clinical Investigation of the Oxford® Meniscal Unicompartmental Knee System
Biomet Orthopedics
NCT00578994
Post-PMA Approval Study: 10 Year Follow-Up IDE Subjects
Corin
NCT00721994
A Clinical Investigation of ArComXL® Polyethylene in Total Hip Replacement
Zimmer Biomet
NCT00698152
Opioid-Free Shoulder Arthroplasty
OrthoCarolina Research Institute
NCT03540030
Continuum™ Metal Bearing System in Total Hip Arthroplasty
Zimmer Biomet
NCT03382652
Ceramic On Ceramic (COC) 36mm PAS IDE Rollover Subjects; Ceramic Acetabular Bearing With Ceramic Femoral Head in Total Hip Replacement
DePuy Orthopaedics
NCT02096198
Acetabular Shell Positioning Using Patient Specific Instruments
The Cleveland Clinic
NCT01791738
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 1 |
| Phase 2 | 1 |
| Phase 4 | 1 |
Top Sponsors
Named interventions
Most-linked intervention names on Avascular Necrosis records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Avascular Necrosis trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Avascular Necrosis page
25 registered trials, 4 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 4 Avascular Necrosis trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Zimmer Biomet sponsors the most Avascular Necrosis trials on record, review their full trial history before evaluating a specific study. See Zimmer Biomet's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Avascular Necrosis condition card totals 25 registered trials; most-linked intervention Acetabular positioning system; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.