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Atrial Fibrillation clinical trials
60 of 204 indexed Atrial Fibrillation trials are currently recruiting.
204 US clinical trials · 60 currently recruiting
Atrial Fibrillation is the subject of 204 registered US clinical trials on ClinicalTrials.gov, 60 of them currently open to new participants. 45 are in Phase 3-4 (later-stage) and 19 in Phase 1-2 (earlier-stage). The most active sponsor is The Cleveland Clinic, running 9 of these trials.
The research picture
Atrial Fibrillation has 204 registered US clinical trials, 60 of them open to new participants right now, about 29% of the total.
- 60
- recruiting participants now
- 29%
- of trials open to enrollment
- 45
- in Phase 3–4 (later-stage)
- 9
- top sponsor: The Cleveland Clinic
Active & Recent Trials
204 total, page 4 of 5
Is Endothelial Function a Predictor of Successful Ablation Therapy Provided to Patients With Atrial Fibrillation?
Itamar-Medical, Israel
NCT02129842
First Arrhythmia Collection of Transvenous and Simultaneous Subcutaneous Implantable Defibrillator Data
Boston Scientific Corporation
NCT01161589
Study to Evaluate the Effect of Ranolazine and Dronedarone When Given Alone and in Combination in Patients With Paroxysmal Atrial Fibrillation
Gilead Sciences
NCT01522651
Screening for Sleep Apnea in Patients Undergoing Atrial Fibrillation Ablation
Beth Israel Deaconess Medical Center
NCT02332096
Temporary Autonomic Blockade to Prevent Atrial Fibrillation After Cardiac Surgery
Joseph Mathew, M.D.
NCT02498769
Esophagus Deviation During Radiofrequency Ablation of Atrial Fibrillation - EASY AF STUDY
S4 Medical
NCT04659213
Short Term Outcomes From Minimally Invasive Surgery for the Treatment of Atrial Fibrillation
Virginia Commonwealth University
NCT00571597
Metformin as an Adjunctive Therapy to Catheter Ablation in Atrial Fibrillation
University of Michigan
NCT04625946
Use of Dabigatran Etexilate to Prevent Stroke and Thromboembolism
Vanderbilt University Medical Center
NCT01976507
General Anesthesia With ETT vs LMA in Patients Undergoing Ablation for Atrial Fibrillation
Virginia Commonwealth University
NCT02896595
The Use of Dual Chamber ICD With Special Programmed Features to Lower the Risk of Inappropriate Shock
Mayo Clinic
NCT00787800
Intra-Cardiac Echocardiography Guided Cardioversion(ICE-CHIP) Study
EP MedSystems
NCT00281073
Selective Complex Fractionated Atrial Electrograms (CFAE) Targeting for Atrial Fibrillation
Biosense Webster
NCT00926783
Peri-device Leakage Closure After LAAO
Cardiovascular Center Frankfurt
NCT04590898
Yoga on Arrhythmia Burden and Quality of Life in Paroxysmal Atrial Fibrillation
Dhanunjaya Lakkireddy, MD, FACC
NCT00798356
Evaluation of Conventional Ablation With or Without Focal Impulse and Rotor Modulation to Eliminate Human AF
Stanford University
NCT02456233
Continued Access Protocol
Medtronic Cardiac Rhythm and Heart Failure
NCT00889681
Prevention of Atrial Fibrillation Following Esophagectomy
Indiana University
NCT00420017
Recording for Potential AF Drivers and Patient Specific Atrial Anatomy & Atrial Electrogram Maps
Virginia Commonwealth University
NCT01581437
Medtronic Concomitant Utilization of Radio Frequency for Atrial Fibrillation CURE-AF/Persistent
Medtronic Cardiac Surgery
NCT00506493
Comparison of Intracardiac Echocardiography and Transesophageal Echocardiography
Elad Anter
NCT02213666
Cardiac Resynchronization Therapy Efficacy Enhancements
Medtronic Cardiac Rhythm and Heart Failure
NCT02222818
Impact of an Atrial Fibrillation Decision Support Tool (AFDST) on Thromboprophylaxis for Atrial Fibrillation
University of Cincinnati
NCT02524977
Implantable Loop Recorders in Post-atrial Fibrillation (AF) Ablation: RPAF-A
The Cleveland Clinic
NCT01061125
The Physiological Effects of Pacing on Catheter Ablation Procedures to Treat Atrial Fibrillation
NYU Langone Health
NCT02766712
Pradaxa Study in Non-valvular Atrial Fibrillation Patients With Severely Impaired Renal Function
Boehringer Ingelheim
NCT01896297
Patient Centered Mobile Health Technology Enabled Atrial Fibrillation Management
Johns Hopkins University
NCT05400837
Post-Market Surveillance With a Novel mHealth Platform
Yale University
NCT03436082
Combined Treatment of Arterial Hypertension and Atrial Fibrillation
Meshalkin Research Institute of Pathology of Circulation
NCT01897545
Esophageal Cooling for AF Ablation
University of Pennsylvania
NCT03691571
ImplemeNtation oF demOnstration pRoject for Health systeMs: Atrial Fibrillation (INFORM-AF) Part 1
Duke University
NCT02569528
OptiSense™ Performance in Detecting Atrial Episodes
Abbott Medical Devices
NCT00870324
Adjunctive Renal Denervation in the Treatment of Atrial Fibrillation
Vivek Reddy
NCT01635998
Esophageal Temperature Management During Cryo AF Ablation (EnsoETM)
Northwestern University
NCT04079634
Safety Monitoring of Patients Having Pulmonary Vein Ablation
The Cleveland Clinic
NCT00590668
FREEZE-AFIB Post-Market Study
AtriCure
NCT05089877
Comparison of Rotational Angiography/Electroanatomical Mapping Fusion Versus CT/Electroanatomical Mapping Fusion to Guide AF Ablation
Steward St. Elizabeth's Medical Center of Boston
NCT01537237
Prospective Elimination Of Distal Coronary Sinus-Left Atrial Connections for Atrial Fibrillation Ablation Trial
University of Pennsylvania
NCT03646643
One More Magnetic Resonance Imaging
Saint Luke's Health System
NCT02293070
Atrial Fibrillation Recurrence in Sleep Apnea
Mayo Clinic
NCT00263757
AF-FLOW Registry to Evaluate Electrographic Flow Mapping in Patients Undergoing Ablation for Atrial Fibrillation
Ablacon
NCT05481359
Effect of Diltiazem on Pharmacokinetics of BMS-914392
Bristol-Myers Squibb
NCT01211808
Relationship Between Autonomic Central Nervous System Activation and Atrial Fibrillation Using Functional MRI (fMRI)
University of Utah
NCT02524028
Long Term Arrhythmia Risk and Cardiovascular Events in Hematopoietic Stem Cell Transplant
Abramson Cancer Center at Penn Medicine
NCT04118530
Evaluation of the Use of Apple Watch Features for Identification of Cardiac Arrhythmias
Apple
NCT03769207
ArcticLine Feasibility Study
Medtronic Cardiac Ablation Solutions
NCT03604263
Siemens 3-D C-Arm CT of the Heart Chambers
The Cleveland Clinic
NCT00619450
Stroke Feasibility Study
AtriCure
NCT01997905
Transatrial Pericardial Separation to Enhance Safety of Subxiphoid Pericardial Access for Left Atrial Appendage Ligation
Henry Ford Health System
NCT06584370
Mapping Electrogram Morphology Recurrence for Atrial Fibrillation Ablation
Jeffrey Goldberger
NCT03082963
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 7 |
| Phase 2 | 12 |
| Phase 3 | 26 |
| Phase 4 | 19 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Atrial Fibrillation Trial Landscape
204 indexed Atrial Fibrillation studies · 60 recruiting (29%).
Phase mix: 45 late (III/IV) vs 19 early (I/II).
Top sponsor: The Cleveland Clinic (9 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Atrial Fibrillation?
PlainTrial tracks 204 US clinical trials for Atrial Fibrillation, of which 60 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Atrial Fibrillation?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.