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Atrial Fibrillation: later-stage trial registry
60 of 204 indexed Atrial Fibrillation trials are currently recruiting, with more weight in Phase 3-4.
Corpus placement: #46 of 28,707 conditions by registered trial count.
204 US clinical trials · 60 currently recruiting · #46 of 28,707 conditions by registered trial count
Atrial Fibrillation: 204 US clinical trials tracked, 60 recruiting.
Atrial Fibrillation is the subject of 204 registered US clinical trials on ClinicalTrials.gov, 60 of them currently open to new participants. 45 are in Phase 3-4 (later-stage) and 19 in Phase 1-2 (earlier-stage). The most active sponsor is The Cleveland Clinic, running 9 of these trials.
Enrollment posture brief
Registry condition atrial-fibrillation
OPEN 60 | RECR 29% | LATE 45 | EARLY 19 | RANK #46 | SPON 9
Volume-matched condition peers
Nearest open-share peer: Addiction (29% recruiting · 17 trials)
Atrial Fibrillation lists 60 open slots (29% of 204 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Atrial Fibrillation on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Atrial Fibrillation is recruiting below its size-band peers.
60 of 204 indexed trials (29.4%) are open to enrollment, against a 37.1% average across 139 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Atrial Fibrillation trials is spread across many organizations.
The Cleveland Clinic accounts for 9 of 204 trials (4.4%). 109 distinct sponsors appear on at least one study for this condition label.
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Typical Atrial Fibrillation enrolment sits around 200 participants.
Median target enrolment is 200 among the 203 trials that report a genuine target (sentinel values excluded). 59 of those (29.1%) plan for fewer than 100 participants.
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Atrial Fibrillation splits between interventional and observational designs.
137 interventional and 67 observational studies make up this index (67.2% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
204 total, page 4 of 5
Is Endothelial Function a Predictor of Successful Ablation Therapy Provided to Patients With Atrial Fibrillation?
Itamar-Medical, Israel
NCT02129842
First Arrhythmia Collection of Transvenous and Simultaneous Subcutaneous Implantable Defibrillator Data
Boston Scientific Corporation
NCT01161589
Study to Evaluate the Effect of Ranolazine and Dronedarone When Given Alone and in Combination in Patients With Paroxysmal Atrial Fibrillation
Gilead Sciences
NCT01522651
Screening for Sleep Apnea in Patients Undergoing Atrial Fibrillation Ablation
Beth Israel Deaconess Medical Center
NCT02332096
Temporary Autonomic Blockade to Prevent Atrial Fibrillation After Cardiac Surgery
Joseph Mathew, M.D.
NCT02498769
Esophagus Deviation During Radiofrequency Ablation of Atrial Fibrillation - EASY AF STUDY
S4 Medical
NCT04659213
Short Term Outcomes From Minimally Invasive Surgery for the Treatment of Atrial Fibrillation
Virginia Commonwealth University
NCT00571597
Metformin as an Adjunctive Therapy to Catheter Ablation in Atrial Fibrillation
University of Michigan
NCT04625946
Use of Dabigatran Etexilate to Prevent Stroke and Thromboembolism
Vanderbilt University Medical Center
NCT01976507
General Anesthesia With ETT vs LMA in Patients Undergoing Ablation for Atrial Fibrillation
Virginia Commonwealth University
NCT02896595
The Use of Dual Chamber ICD With Special Programmed Features to Lower the Risk of Inappropriate Shock
Mayo Clinic
NCT00787800
Intra-Cardiac Echocardiography Guided Cardioversion(ICE-CHIP) Study
EP MedSystems
NCT00281073
Selective Complex Fractionated Atrial Electrograms (CFAE) Targeting for Atrial Fibrillation
Biosense Webster
NCT00926783
Peri-device Leakage Closure After LAAO
Cardiovascular Center Frankfurt
NCT04590898
Yoga on Arrhythmia Burden and Quality of Life in Paroxysmal Atrial Fibrillation
Dhanunjaya Lakkireddy, MD, FACC
NCT00798356
Evaluation of Conventional Ablation With or Without Focal Impulse and Rotor Modulation to Eliminate Human AF
Stanford University
NCT02456233
Continued Access Protocol
Medtronic Cardiac Rhythm and Heart Failure
NCT00889681
Prevention of Atrial Fibrillation Following Esophagectomy
Indiana University
NCT00420017
Recording for Potential AF Drivers and Patient Specific Atrial Anatomy & Atrial Electrogram Maps
Virginia Commonwealth University
NCT01581437
Medtronic Concomitant Utilization of Radio Frequency for Atrial Fibrillation CURE-AF/Persistent
Medtronic Cardiac Surgery
NCT00506493
Comparison of Intracardiac Echocardiography and Transesophageal Echocardiography
Elad Anter
NCT02213666
Cardiac Resynchronization Therapy Efficacy Enhancements
Medtronic Cardiac Rhythm and Heart Failure
NCT02222818
Impact of an Atrial Fibrillation Decision Support Tool (AFDST) on Thromboprophylaxis for Atrial Fibrillation
University of Cincinnati
NCT02524977
Implantable Loop Recorders in Post-atrial Fibrillation (AF) Ablation: RPAF-A
The Cleveland Clinic
NCT01061125
The Physiological Effects of Pacing on Catheter Ablation Procedures to Treat Atrial Fibrillation
NYU Langone Health
NCT02766712
Pradaxa Study in Non-valvular Atrial Fibrillation Patients With Severely Impaired Renal Function
Boehringer Ingelheim
NCT01896297
Patient Centered Mobile Health Technology Enabled Atrial Fibrillation Management
Johns Hopkins University
NCT05400837
Post-Market Surveillance With a Novel mHealth Platform
Yale University
NCT03436082
Combined Treatment of Arterial Hypertension and Atrial Fibrillation
Meshalkin Research Institute of Pathology of Circulation
NCT01897545
Esophageal Cooling for AF Ablation
University of Pennsylvania
NCT03691571
ImplemeNtation oF demOnstration pRoject for Health systeMs: Atrial Fibrillation (INFORM-AF) Part 1
Duke University
NCT02569528
OptiSense™ Performance in Detecting Atrial Episodes
Abbott Medical Devices
NCT00870324
Adjunctive Renal Denervation in the Treatment of Atrial Fibrillation
Vivek Reddy
NCT01635998
Esophageal Temperature Management During Cryo AF Ablation (EnsoETM)
Northwestern University
NCT04079634
Safety Monitoring of Patients Having Pulmonary Vein Ablation
The Cleveland Clinic
NCT00590668
FREEZE-AFIB Post-Market Study
AtriCure
NCT05089877
Comparison of Rotational Angiography/Electroanatomical Mapping Fusion Versus CT/Electroanatomical Mapping Fusion to Guide AF Ablation
Steward St. Elizabeth's Medical Center of Boston
NCT01537237
Prospective Elimination Of Distal Coronary Sinus-Left Atrial Connections for Atrial Fibrillation Ablation Trial
University of Pennsylvania
NCT03646643
One More Magnetic Resonance Imaging
Saint Luke's Health System
NCT02293070
Atrial Fibrillation Recurrence in Sleep Apnea
Mayo Clinic
NCT00263757
AF-FLOW Registry to Evaluate Electrographic Flow Mapping in Patients Undergoing Ablation for Atrial Fibrillation
Ablacon
NCT05481359
Effect of Diltiazem on Pharmacokinetics of BMS-914392
Bristol-Myers Squibb
NCT01211808
Relationship Between Autonomic Central Nervous System Activation and Atrial Fibrillation Using Functional MRI (fMRI)
University of Utah
NCT02524028
Long Term Arrhythmia Risk and Cardiovascular Events in Hematopoietic Stem Cell Transplant
Abramson Cancer Center at Penn Medicine
NCT04118530
Evaluation of the Use of Apple Watch Features for Identification of Cardiac Arrhythmias
Apple
NCT03769207
ArcticLine Feasibility Study
Medtronic Cardiac Ablation Solutions
NCT03604263
Siemens 3-D C-Arm CT of the Heart Chambers
The Cleveland Clinic
NCT00619450
Stroke Feasibility Study
AtriCure
NCT01997905
Transatrial Pericardial Separation to Enhance Safety of Subxiphoid Pericardial Access for Left Atrial Appendage Ligation
Henry Ford Health System
NCT06584370
Mapping Electrogram Morphology Recurrence for Atrial Fibrillation Ablation
Jeffrey Goldberger
NCT03082963
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 7 |
| Phase 2 | 12 |
| Phase 3 | 26 |
| Phase 4 | 19 |
Top Sponsors
Named interventions
Most-linked intervention names on Atrial Fibrillation records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Atrial Fibrillation trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Atrial Fibrillation page
204 registered trials, 60 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 60 Atrial Fibrillation trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- The Cleveland Clinic sponsors the most Atrial Fibrillation trials on record, review their full trial history before evaluating a specific study. See The Cleveland Clinic's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Atrial Fibrillation condition card totals 204 registered trials; most-linked intervention Placebo; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.