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ClinicalTrials.gov 60 recruiting now official registry

Atrial Fibrillation clinical trials

60 of 204 indexed Atrial Fibrillation trials are currently recruiting.

204 US clinical trials · 60 currently recruiting

Atrial Fibrillation is the subject of 204 registered US clinical trials on ClinicalTrials.gov, 60 of them currently open to new participants. 45 are in Phase 3-4 (later-stage) and 19 in Phase 1-2 (earlier-stage). The most active sponsor is The Cleveland Clinic, running 9 of these trials.

The research picture

Atrial Fibrillation has 204 registered US clinical trials, 60 of them open to new participants right now, about 29% of the total.

60
recruiting participants now
29%
of trials open to enrollment
45
in Phase 3–4 (later-stage)
9
top sponsor: The Cleveland Clinic
Phase 17Phase 212Phase 326Phase 419

Active & Recent Trials

204 total, page 4 of 5

COMPLETED 150 participants

Is Endothelial Function a Predictor of Successful Ablation Therapy Provided to Patients With Atrial Fibrillation?

Itamar-Medical, Israel

NCT02129842

COMPLETED 142 participants

First Arrhythmia Collection of Transvenous and Simultaneous Subcutaneous Implantable Defibrillator Data

Boston Scientific Corporation

NCT01161589

COMPLETED Phase 2 134 participants

Study to Evaluate the Effect of Ranolazine and Dronedarone When Given Alone and in Combination in Patients With Paroxysmal Atrial Fibrillation

Gilead Sciences

NCT01522651

COMPLETED 130 participants

Screening for Sleep Apnea in Patients Undergoing Atrial Fibrillation Ablation

Beth Israel Deaconess Medical Center

NCT02332096

COMPLETED Phase 1 130 participants

Temporary Autonomic Blockade to Prevent Atrial Fibrillation After Cardiac Surgery

Joseph Mathew, M.D.

NCT02498769

COMPLETED NA 129 participants

Esophagus Deviation During Radiofrequency Ablation of Atrial Fibrillation - EASY AF STUDY

S4 Medical

NCT04659213

COMPLETED 118 participants

Short Term Outcomes From Minimally Invasive Surgery for the Treatment of Atrial Fibrillation

Virginia Commonwealth University

NCT00571597

COMPLETED Phase 4 117 participants

Metformin as an Adjunctive Therapy to Catheter Ablation in Atrial Fibrillation

University of Michigan

NCT04625946

COMPLETED Phase 4 101 participants

Use of Dabigatran Etexilate to Prevent Stroke and Thromboembolism

Vanderbilt University Medical Center

NCT01976507

COMPLETED NA 100 participants

General Anesthesia With ETT vs LMA in Patients Undergoing Ablation for Atrial Fibrillation

Virginia Commonwealth University

NCT02896595

COMPLETED Phase 4 100 participants

The Use of Dual Chamber ICD With Special Programmed Features to Lower the Risk of Inappropriate Shock

Mayo Clinic

NCT00787800

COMPLETED Phase 1 95 participants

Intra-Cardiac Echocardiography Guided Cardioversion(ICE-CHIP) Study

EP MedSystems

NCT00281073

COMPLETED Phase 4 86 participants

Selective Complex Fractionated Atrial Electrograms (CFAE) Targeting for Atrial Fibrillation

Biosense Webster

NCT00926783

COMPLETED 85 participants

Peri-device Leakage Closure After LAAO

Cardiovascular Center Frankfurt

NCT04590898

COMPLETED NA 84 participants

Yoga on Arrhythmia Burden and Quality of Life in Paroxysmal Atrial Fibrillation

Dhanunjaya Lakkireddy, MD, FACC

NCT00798356

COMPLETED NA 84 participants

Evaluation of Conventional Ablation With or Without Focal Impulse and Rotor Modulation to Eliminate Human AF

Stanford University

NCT02456233

COMPLETED NA 81 participants

Continued Access Protocol

Medtronic Cardiac Rhythm and Heart Failure

NCT00889681

COMPLETED Phase 4 80 participants

Prevention of Atrial Fibrillation Following Esophagectomy

Indiana University

NCT00420017

COMPLETED NA 78 participants

Recording for Potential AF Drivers and Patient Specific Atrial Anatomy & Atrial Electrogram Maps

Virginia Commonwealth University

NCT01581437

COMPLETED Phase 3 75 participants

Medtronic Concomitant Utilization of Radio Frequency for Atrial Fibrillation CURE-AF/Persistent

Medtronic Cardiac Surgery

NCT00506493

COMPLETED 72 participants

Comparison of Intracardiac Echocardiography and Transesophageal Echocardiography

Elad Anter

NCT02213666

COMPLETED NA 71 participants

Cardiac Resynchronization Therapy Efficacy Enhancements

Medtronic Cardiac Rhythm and Heart Failure

NCT02222818

COMPLETED NA 70 participants

Impact of an Atrial Fibrillation Decision Support Tool (AFDST) on Thromboprophylaxis for Atrial Fibrillation

University of Cincinnati

NCT02524977

COMPLETED 68 participants

Implantable Loop Recorders in Post-atrial Fibrillation (AF) Ablation: RPAF-A

The Cleveland Clinic

NCT01061125

COMPLETED NA 64 participants

The Physiological Effects of Pacing on Catheter Ablation Procedures to Treat Atrial Fibrillation

NYU Langone Health

NCT02766712

COMPLETED Phase 4 63 participants

Pradaxa Study in Non-valvular Atrial Fibrillation Patients With Severely Impaired Renal Function

Boehringer Ingelheim

NCT01896297

COMPLETED NA 61 participants

Patient Centered Mobile Health Technology Enabled Atrial Fibrillation Management

Johns Hopkins University

NCT05400837

COMPLETED 60 participants

Post-Market Surveillance With a Novel mHealth Platform

Yale University

NCT03436082

COMPLETED Phase 2 60 participants

Combined Treatment of Arterial Hypertension and Atrial Fibrillation

Meshalkin Research Institute of Pathology of Circulation

NCT01897545

COMPLETED NA 55 participants

Esophageal Cooling for AF Ablation

University of Pennsylvania

NCT03691571

COMPLETED 52 participants

ImplemeNtation oF demOnstration pRoject for Health systeMs: Atrial Fibrillation (INFORM-AF) Part 1

Duke University

NCT02569528

COMPLETED 50 participants

OptiSense™ Performance in Detecting Atrial Episodes

Abbott Medical Devices

NCT00870324

COMPLETED NA 50 participants

Adjunctive Renal Denervation in the Treatment of Atrial Fibrillation

Vivek Reddy

NCT01635998

COMPLETED NA 42 participants

Esophageal Temperature Management During Cryo AF Ablation (EnsoETM)

Northwestern University

NCT04079634

COMPLETED 42 participants

Safety Monitoring of Patients Having Pulmonary Vein Ablation

The Cleveland Clinic

NCT00590668

COMPLETED 39 participants

FREEZE-AFIB Post-Market Study

AtriCure

NCT05089877

COMPLETED 37 participants

Comparison of Rotational Angiography/Electroanatomical Mapping Fusion Versus CT/Electroanatomical Mapping Fusion to Guide AF Ablation

Steward St. Elizabeth's Medical Center of Boston

NCT01537237

COMPLETED NA 35 participants

Prospective Elimination Of Distal Coronary Sinus-Left Atrial Connections for Atrial Fibrillation Ablation Trial

University of Pennsylvania

NCT03646643

COMPLETED NA 32 participants

One More Magnetic Resonance Imaging

Saint Luke's Health System

NCT02293070

COMPLETED NA 25 participants

Atrial Fibrillation Recurrence in Sleep Apnea

Mayo Clinic

NCT00263757

COMPLETED 25 participants

AF-FLOW Registry to Evaluate Electrographic Flow Mapping in Patients Undergoing Ablation for Atrial Fibrillation

Ablacon

NCT05481359

COMPLETED Phase 1 24 participants

Effect of Diltiazem on Pharmacokinetics of BMS-914392

Bristol-Myers Squibb

NCT01211808

COMPLETED 21 participants

Relationship Between Autonomic Central Nervous System Activation and Atrial Fibrillation Using Functional MRI (fMRI)

University of Utah

NCT02524028

COMPLETED 21 participants

Long Term Arrhythmia Risk and Cardiovascular Events in Hematopoietic Stem Cell Transplant

Abramson Cancer Center at Penn Medicine

NCT04118530

COMPLETED NA 17 participants

Evaluation of the Use of Apple Watch Features for Identification of Cardiac Arrhythmias

Apple

NCT03769207

COMPLETED NA 17 participants

ArcticLine Feasibility Study

Medtronic Cardiac Ablation Solutions

NCT03604263

COMPLETED 16 participants

Siemens 3-D C-Arm CT of the Heart Chambers

The Cleveland Clinic

NCT00619450

COMPLETED Phase 1 13 participants

Stroke Feasibility Study

AtriCure

NCT01997905

COMPLETED NA 13 participants

Transatrial Pericardial Separation to Enhance Safety of Subxiphoid Pericardial Access for Left Atrial Appendage Ligation

Henry Ford Health System

NCT06584370

COMPLETED NA 10 participants

Mapping Electrogram Morphology Recurrence for Atrial Fibrillation Ablation

Jeffrey Goldberger

NCT03082963

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Phase Distribution

PhaseTrial count
Phase 1 7
Phase 2 12
Phase 3 26
Phase 4 19

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Atrial Fibrillation Trial Landscape

204 indexed Atrial Fibrillation studies · 60 recruiting (29%).

Phase mix: 45 late (III/IV) vs 19 early (I/II).

Top sponsor: The Cleveland Clinic (9 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Atrial Fibrillation?

PlainTrial tracks 204 US clinical trials for Atrial Fibrillation, of which 60 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Atrial Fibrillation?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.