Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT00506493 · ClinicalTrials.gov registry record · Phase 3
Medtronic Concomitant Utilization of Radio Frequency for Atrial Fibrillation CURE-AF/Persistent
A Phase 3 study of Atrial Fibrillation, sponsored by Medtronic Cardiac Surgery.
- Completed
- Registry status
- Phase 3
- Development phase
- 75
- Enrollment target
- 15
- Study locations
NCT00506493: Completed Phase 3 study of Atrial Fibrillation, sponsored by Medtronic Cardiac Surgery.
NCT00506493 is a Phase 3 study of Atrial Fibrillation that has completed, run by Medtronic Cardiac Surgery. The registered enrollment target is 75 participants, below the 2,997-participant average among 202 other Atrial Fibrillation trials with a reported enrollment target (97% lower). The trial reports 15 study locations across 13 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00506493, a Phase 3 study of Atrial Fibrillation, has completed, sponsored by Medtronic Cardiac Surgery.
- COMPLETED
- Registry status
- Phase 3
- Development phase
- 75 participants
- Enrollment target
- 15
- Study locations
Study Summary
This investigation is a prospective, nonrandomized multicenter clinical trial evaluating the outcome of patients with atrial fibrillation (AF) requiring concomitant open heart surgery plus the Cardioblate Surgical Ablation System using the modified Maze III procedure. The trial population includes patients requiring valve replacements or repairs, atrial septal defect (ASD) repairs, patent foramen ovale (PFO) closure or coronary artery bypass graft (CABG) procedures. The study objectives are to demonstrate that the Medtronic Cardioblate Surgical Ablation System can safely and effectively treat persistent AF patients.
Primary Outcome
Subject's cardiac rhythm was assessed by wearing a Holter Monitor for 24 hours
Conditions Studied
Interventions
- DEVICE Cardioblate Surgical Ablation System
- PROCEDURE Surgical RF Ablation
Study Locations (15)
California
- East Bay Cardiovascular & Thoracic Associates - Concord
- University of Southern California - Los Angeles
- Eisenhower Medical Center - Palm Springs
Arizona
- Southwest Heart and Lung - Phoenix
Florida
- Cardiac Surgical Associates of Florida - St. Petersburg
Illinois
- Northwestern Memorial Hospital - Chicago
Minnesota
- Mayo/St. Mary's Hospital - Rochester
Missouri
- Washington University School of Medicine - St Louis
New Jersey
- Englewood Hospital and Medical Center - Englewood
New Mexico
- New Mexico Heart Institute - Albuquerque
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 75 participants |
| Start Date | 2007-09 |
| Est. Completion | 2011-10 |
| Phase | Phase 3 |
What the finished NCT00506493 record still lists
NCT00506493 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 75 participants, a relatively small participant target, below the 2,997-participant average among 202 other Atrial Fibrillation trials with a reported enrollment target (97% lower).
The record links to 1 condition, with Atrial Fibrillation appearing as the primary indexed condition, and to 2 interventions - of which Cardioblate Surgical Ablation System is the first listed.
NCT00506493 lists 15 locations in 13 states (California, Arizona, Florida).
Frequently Asked Questions
What is clinical trial NCT00506493 about?
NCT00506493 is a clinical study titled "Medtronic Concomitant Utilization of Radio Frequency for Atrial Fibrillation CURE-AF/Persistent". This investigation is a prospective, nonrandomized multicenter clinical trial evaluating the outcome of patients with atrial fibrillation (AF) requiring concomitant open heart surgery plus the Cardioblate Surgical Ablation System using the modified Maze III procedure. The trial population includes p...
What is the current status of trial NCT00506493?
This trial is currently completed. It is a Phase 3 study. The enrollment target is 75 participants. The study started on 2007-09. Estimated completion is 2011-10.
What conditions does trial NCT00506493 study?
This clinical trial studies the following conditions: Atrial Fibrillation.
What interventions are being tested in trial NCT00506493?
The interventions under investigation include: Cardioblate Surgical Ablation System (DEVICE), Surgical RF Ablation (PROCEDURE).
Who is sponsoring clinical trial NCT00506493?
This trial is sponsored by Medtronic Cardiac Surgery, which has 7 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT00506493 being conducted?
This trial has 15 study locations across Arizona, California, Florida, Illinois, Minnesota. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Atrial Fibrillation
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT00506493's enrollment target sits among peer trials
75 156th of 202 higher than 46 of 202 other Atrial Fibrillation trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Atrial Fibrillation trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
The Rhythm Evaluation for AntiCoagulaTion With Continuous Monitoring of Atrial Fibrillation
RECRUITING · Phase 3
-
Comparing Magnesium 2g Versus 4g Versus Placebo in the Incidence of Treating AFF RVR
RECRUITING · Phase 3
-
Anticoagulation in ICH Survivors for Stroke Prevention and Recovery
RECRUITING · Phase 3
-
Semaglutide for Metabolic Intervention and Adipose Loss to Treat Atrial Fibrillation
RECRUITING · Phase 3
-
Dapagliflozin in Patients With Atrial Fibrillation (DAPA-AF)
RECRUITING · Phase 3
-
Anticoagulation for New-Onset Post-Operative Atrial Fibrillation After CABG
RECRUITING · Phase 3
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT01535430 · 75 participants
Assessment of Eloquent Function in Brain Tumor Patients
- NCT01542879 · 75 participants · Phase 1
Development of Radiation Free Whole Body Magnetic Resonance (MR) Imaging Technique for Staging Children With Cancer
- NCT02232191 · 75 participants · Phase 2
Immunologic Response to Pneumococcal Polysaccharide Vaccine in Splenic Injury Patients
- NCT02754544 · 75 participants · NA
Electrocorticography in Mapping Functional Brain Areas During Surgery in Patients With Brain Tumors
Similar registry start date
- NCT05988463 · started 2027-01-01 · Phase 1
Dose-Escalation Study of Artesunate Patients With IPF
- NCT07219706 · started 2026-12-10 · NA
Dietary Fiber and Time Restricted Eating
- NCT02831335 · started 2026-12-01
Technical Development of Multi-Parametric Renocerebral MRI
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia