Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT03109314 · ClinicalTrials.gov registry record · Phase 4
Combining Donepezil With Perceptual Learning in Normal and Amblyopic Human The Effect of Donepezil on Perceptual Learning in Adult Amblyopia
A Phase 4 study of Amblyopia, sponsored by Dennis Levi.
- Completed
- Registry status
- Phase 4
- Development phase
- 20
- Enrollment target
- 1
- Study location
NCT03109314: Completed Phase 4 study of Amblyopia, sponsored by Dennis Levi.
NCT03109314 is a Phase 4 study of Amblyopia that has completed, run by Dennis Levi. The registered enrollment target is 20 participants, below the 165-participant average among 24 other Amblyopia trials with a reported enrollment target (88% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03109314, a Phase 4 study of Amblyopia, has completed, sponsored by Dennis Levi.
- COMPLETED
- Registry status
- Phase 4
- Development phase
- 20 participants
- Enrollment target
- 1
- Study location
Study Summary
The research deals with amblyopia or lazy eye, a condition that affects about 3% of the population, and results in a variety of visual deficits. Recent work suggests that there is limited neural plasticity in the visual system of adults with amblyopia. This study is aimed at understanding and increasing this plasticity. In this study, the investigators aim to understand how the amblyopic brain learns and how this process is affected by a drug called donepezil, which is sometimes given as a treatment for Alzheimer's disease. The investigators hope that this study will help to identify the chemical components that help the brain to learn, as well as the mechanism of amblyopia. The investigators also plan to test the normal periphery, as control.
Primary Outcome
During training, for each trial, participants' responses can be categorized as correct or incorrect. The investigators will use the percent-correct performance to quantify the performance in each block, and this percent-correct performance will be measured throughout training (i.e. for each block on each day (10 blocks per day), and for 10 training days).
Conditions Studied
Interventions
- DRUG Donepezil
- BEHAVIORAL Single-letter training
- BEHAVIORAL Uncrowd training
Study Locations (1)
California
- University of California, Berkeley - Berkeley
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 20 participants |
| Start Date | 2012-05-01 |
| Est. Completion | 2018-12-01 |
| Phase | Phase 4 |
What the finished NCT03109314 record still lists
NCT03109314 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 20 participants, a relatively small participant target, below the 165-participant average among 24 other Amblyopia trials with a reported enrollment target (88% lower).
The record links to 1 condition, with Amblyopia appearing as the primary indexed condition, and to 3 interventions - of which Donepezil is the first listed.
NCT03109314 reports a single indexed study location in California.
Frequently Asked Questions
What is clinical trial NCT03109314 about?
NCT03109314 is a clinical study titled "Combining Donepezil With Perceptual Learning in Normal and Amblyopic Human The Effect of Donepezil on Perceptual Learning in Adult Amblyopia". The research deals with amblyopia or lazy eye, a condition that affects about 3% of the population, and results in a variety of visual deficits. Recent work suggests that there is limited neural plasticity in the visual system of adults with amblyopia. This study is aimed at understanding and increa...
What is the current status of trial NCT03109314?
This trial is currently completed. It is a Phase 4 study. The enrollment target is 20 participants. The study started on 2012-05-01. Estimated completion is 2018-12-01.
What conditions does trial NCT03109314 study?
This clinical trial studies the following conditions: Amblyopia.
What interventions are being tested in trial NCT03109314?
The interventions under investigation include: Donepezil (DRUG), Single-letter training (BEHAVIORAL), Uncrowd training (BEHAVIORAL).
Who is sponsoring clinical trial NCT03109314?
This trial is sponsored by Dennis Levi, which has 1 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT03109314 being conducted?
This trial has 1 study location across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Amblyopia
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT03109314's enrollment target sits among peer trials
20 23rd of 24 higher than 1 of 24 other Amblyopia trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Amblyopia trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
Noninvasive Brain Stimulation in Adult Amblyopia
RECRUITING · NA
-
OCT Eccentric Fixation and Amblyopia in Children
RECRUITING · NA
-
Visual Function Abnormalities in Strabismus and Amblyopia and Response to Therapy
RECRUITING
-
A Randomized Trial to Evaluate Sequential vs Simultaneous Patching
RECRUITING · Phase 3
-
Dichoptic Treatment for Amblyopia in Children 4 to 7 Years of Age
RECRUITING · Phase 3
-
Dichoptic Treatment for Amblyopia in Children 8 to 12 Years of Age
RECRUITING · Phase 3
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT00573339 · 20 participants
Cardiac Magnetic Resonance Imaging (MRI) Normal Reference Control Group Testing
- NCT00692939 · 20 participants · Phase 1
Autologous Stem Cell Transplantation for Crohn's Disease
- NCT00967785 · 20 participants · Phase 1
A Phase I Study of Mozobil in the Treatment of Patients With WHIMS
- NCT01406691 · 20 participants · Phase 4
Light Flashes to Treat Delayed Sleep Phase Disorder (DSPD)
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI