National Human Genome Research Institute (NHGRI)

Compiled by PlainTrial · August 8, 2026

Open enrollment with an early-phase pipeline tilt

According to ClinicalTrials.gov-derived indexes, National Human Genome Research Institute (NHGRI) sits in the top decile of US sponsors by registered trial count (#161 of 15,742 sponsors by registered trial count).

185 total trials 30 currently recruiting 143 completed early-phase tilt top decile by trial count

National Human Genome Research Institute (NHGRI): 185 sponsored US clinical trials, 30 recruiting.

National Human Genome Research Institute (NHGRI) sponsors 185 registered US clinical trials on ClinicalTrials.gov, 30 of them currently recruiting, and 143 completed. 0 of these trials are in Phase 3-4 (later-stage) and 18 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Proteus Syndrome, with 3 trials.

National Human Genome Research Institute (NHGRI) ranks in the top decile of sponsors by registered trial count (#161 of 15,742 sponsors by registered trial count). Volume at this scale usually reflects a long institutional pipeline, read phase tilt and therapeutic areas below before treating it as current-year activity.

Trial completion reliability score

C 75/100

143 of 152 decided trials (Completed vs. Terminated on ClinicalTrials.gov) reached their planned completion (94.1%), vs. national p10 68.4% / p90 100% among 1,234 sponsors with at least 10 decided trials. Still-open trials (Recruiting, Active-not-recruiting, Not-yet-recruiting) are excluded since they have not reached an outcome yet.

Open and recent trials

185 total, page 2 of 4

COMPLETED Phase 2

An Open Label Phase 2 Study of ManNAc in Subjects With GNE Myopathy

NCT02346461

National Human Genome Research Institute (NHGRI)

Top-decile sponsor footprint

Open and recent trials

An Open Label Phase 2 Study of ManNAc in Subjects With GNE Myopathy

Maternal Inborn Errors of Metabolism in Pregnancy: A Pregnancy Registry Protocol

Dabrafenib and Trametinib in People With BRAF V600E Mutation Positive Lesions in Erdheim Chester Disease

Physicians' Experiences With and Attitudes Toward Non-Medical Sex Selection Through Preimplantation Genetic Diagnosis

Where Does Hope Fit In? The Relationship Between Hope, Uncertainty, and Coping Efficacy in Mothers of Children With Duchenne/Becker Muscular Dystrophy

Insights Into Microbiome and Environmental Contributions to Sickle Cell Disease and Leg Ulcers Study (INSIGHTS Study)

Study on Moebius Syndrome and Congenital Facial Weakness Disorders

A Study of Consent Forms for Whole Exome and Whole Genome Sequencing

Treatment of SCID Due to ADA Deficiency With Autologous Transplantation of Cord Blood or Hematopoietic CD 34+ Cells After Addition of a Normal Human ADA cDNA by the EFS-ADA Lentiviral Vector

Black Family Eating Behaviors Study

Participation in a Research Registry for Immune Disorders

The Genetic Basis of Congenital Heart Disease in Africa

Patient Perspectives and Doctor Visits

The Role of Uncertainty in Coping: The Experience of Parents of Children With Undiagnosed Medical Conditions

Adaptation to Living With a BRCA1/2 Mutation

Genetic Studies of Non-Alcoholic Fatty Liver Disease

Effect of Lung Cancer Diagnoses on Family Behaviors

Genetic, Brain Structure, and Environmental Effects on ADHD

Phase I Clinical Trial of ManNAc in Patients With GNE Myopathy or Hereditary Inclusion Body Myopathy (HIBM)

EPI-743 for Metabolism or Mitochondrial Disorders

The Clinical Study of Sex Chromosome Variants

Developing the Family Map: Looking at Communal Coping

Living With Frontotemporal Dementia

Testing Spanish-language Genetic Literacy

Uncertain Genetic Test Results for Lynch Syndrome

Weight Management Interactions in a Virtual Clinical Environment

Inherited Diseases, Caregiving, and Social Networks

Family Genetics Health Education and Healthy Behaviors

The NIH UNI Study: Urea Cycle Disorders, Nutrition and Immunity

Clinical and Pathophysiological Investigations Into Erdheim Chester Disease

Family Communication of Hereditary Breast and Ovarian Cancer Risk Among African Americans

The Role of Family Functioning in Promoting Adaptation in Siblings of Individuals With Duchenne Muscular Dystrophy (DMD)

Informed Consent for Whole Genome Sequencing: Ideals and Norms Referenced by Early Participants

Personalized Genomic Research

Mothers' Thoughts About Kids and Eating

The PTC124 (Ataluren) Clinical Trial for Duchenne Muscular Dystrophy: Exploration of the Experiences of Parents, Clinician Researchers, and the Industry Sponsor

The Role of Social Comparisons in Coping and Quality of Life Following a Prostate Cancer Diagnosis

A Coping Effectiveness Training Intervention for Caregivers of Children With Autism Spectrum: A Feasibility Study

The Perceived Impact of Children s Risk Status for Hypertrophic Cardiomyopathy on Families: an Exploratory Study

Parents With Bipolar Disorder: Relationship of Adaptation to Own Illness With Risk Perception and Coping With Perceived Risk to a Child

The Experience of Uncertainty in Parents of Children With an Undiagnosed Medical Condition

Reactions to Disease Risk Information

The Roles of Trust and Respect in Patient Reactions to Race-based and Personalized Medicine Vignettes: An Experimental Study

Adaptation Among Adolescents and Adults With Klinefelter Syndrome

The Role of Family Functioning in Adaptation to Being a Caregiver of an Individual With Rett Syndrome

The Nosology and Etiology of Leukodystrophies of Unknown Causes

Clinical, Cellular, and Molecular Investigation Into Oculocutaneous Albinism

Clinical and Genetic Studies of VACTERL Association

Cultural Congruence in International Genetics Research

Use of Population Descriptors in Human Genetic Research

Phase Distribution

Therapeutic Areas

What is open in the National Human Genome Research Institute (NHGRI) pipeline

National Human Genome Research Institute (NHGRI): open-pipeline peers nationwide

Sponsors near 185 trials (± recruiting share)

Sponsors near 16% open enrollment (± trial volume)

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