National Human Genome Research Institute (NHGRI)

185 total trials 30 currently recruiting 143 completed

National Human Genome Research Institute (NHGRI) sponsors 185 registered US clinical trials on ClinicalTrials.gov, 30 of them currently recruiting, and 143 completed. 0 of these trials are in Phase 3-4 (later-stage) and 18 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Proteus Syndrome, with 3 trials.

Trial Pipeline

185 total, page 2 of 4

COMPLETED Phase 2

An Open Label Phase 2 Study of ManNAc in Subjects With GNE Myopathy

NCT02346461

COMPLETED

Maternal Inborn Errors of Metabolism in Pregnancy: A Pregnancy Registry Protocol

NCT02322177

COMPLETED Phase 2

Dabrafenib and Trametinib in People With BRAF V600E Mutation Positive Lesions in Erdheim Chester Disease

NCT02281760

COMPLETED

Physicians' Experiences With and Attitudes Toward Non-Medical Sex Selection Through Preimplantation Genetic Diagnosis

NCT02225171

COMPLETED

Where Does Hope Fit In? The Relationship Between Hope, Uncertainty, and Coping Efficacy in Mothers of Children With Duchenne/Becker Muscular Dystrophy

NCT02194725

COMPLETED

Insights Into Microbiome and Environmental Contributions to Sickle Cell Disease and Leg Ulcers Study (INSIGHTS Study)

NCT02156102

COMPLETED

Study on Moebius Syndrome and Congenital Facial Weakness Disorders

NCT02055248

COMPLETED

A Study of Consent Forms for Whole Exome and Whole Genome Sequencing

NCT01927770

COMPLETED Phase 1

Treatment of SCID Due to ADA Deficiency With Autologous Transplantation of Cord Blood or Hematopoietic CD 34+ Cells After Addition of a Normal Human ADA cDNA by the EFS-ADA Lentiviral Vector

NCT02022696

COMPLETED

Black Family Eating Behaviors Study

NCT02015078

COMPLETED

Participation in a Research Registry for Immune Disorders

NCT01953016

COMPLETED

The Genetic Basis of Congenital Heart Disease in Africa

NCT01952171

COMPLETED

Patient Perspectives and Doctor Visits

NCT01888913

COMPLETED

The Role of Uncertainty in Coping: The Experience of Parents of Children With Undiagnosed Medical Conditions

NCT01905865

COMPLETED

Adaptation to Living With a BRCA1/2 Mutation

NCT01866865

TERMINATED

Genetic Studies of Non-Alcoholic Fatty Liver Disease

NCT01629095

COMPLETED

Effect of Lung Cancer Diagnoses on Family Behaviors

NCT01862770

COMPLETED

Genetic, Brain Structure, and Environmental Effects on ADHD

NCT01721720

COMPLETED Phase 1

Phase I Clinical Trial of ManNAc in Patients With GNE Myopathy or Hereditary Inclusion Body Myopathy (HIBM)

NCT01634750

COMPLETED Phase 1

EPI-743 for Metabolism or Mitochondrial Disorders

NCT01642056

COMPLETED

The Clinical Study of Sex Chromosome Variants

NCT01661010

COMPLETED

Developing the Family Map: Looking at Communal Coping

NCT01633021

TERMINATED

Living With Frontotemporal Dementia

NCT01738386

COMPLETED

Testing Spanish-language Genetic Literacy

NCT01610583

COMPLETED

Uncertain Genetic Test Results for Lynch Syndrome

NCT01646112

COMPLETED

Weight Management Interactions in a Virtual Clinical Environment

NCT01443910

COMPLETED

Inherited Diseases, Caregiving, and Social Networks

NCT01498263

COMPLETED

Family Genetics Health Education and Healthy Behaviors

NCT01498276

TERMINATED

The NIH UNI Study: Urea Cycle Disorders, Nutrition and Immunity

NCT01421888

COMPLETED

Clinical and Pathophysiological Investigations Into Erdheim Chester Disease

NCT01417520

TERMINATED

Family Communication of Hereditary Breast and Ovarian Cancer Risk Among African Americans

NCT01374685

TERMINATED

The Role of Family Functioning in Promoting Adaptation in Siblings of Individuals With Duchenne Muscular Dystrophy (DMD)

NCT01386515

COMPLETED

Informed Consent for Whole Genome Sequencing: Ideals and Norms Referenced by Early Participants

NCT01369953

COMPLETED

Personalized Genomic Research

NCT01294345

COMPLETED NA

Mothers' Thoughts About Kids and Eating

NCT01087346

COMPLETED

The PTC124 (Ataluren) Clinical Trial for Duchenne Muscular Dystrophy: Exploration of the Experiences of Parents, Clinician Researchers, and the Industry Sponsor

NCT01182324

COMPLETED

The Role of Social Comparisons in Coping and Quality of Life Following a Prostate Cancer Diagnosis

NCT01176526

COMPLETED NA

A Coping Effectiveness Training Intervention for Caregivers of Children With Autism Spectrum: A Feasibility Study

NCT01168284

COMPLETED

The Perceived Impact of Children s Risk Status for Hypertrophic Cardiomyopathy on Families: an Exploratory Study

NCT01160536

COMPLETED

Parents With Bipolar Disorder: Relationship of Adaptation to Own Illness With Risk Perception and Coping With Perceived Risk to a Child

NCT01012180

COMPLETED

The Experience of Uncertainty in Parents of Children With an Undiagnosed Medical Condition

NCT00955370

COMPLETED NA

Reactions to Disease Risk Information

NCT00774254

COMPLETED

The Roles of Trust and Respect in Patient Reactions to Race-based and Personalized Medicine Vignettes: An Experimental Study

NCT00911833

COMPLETED

Adaptation Among Adolescents and Adults With Klinefelter Syndrome

NCT00896272

COMPLETED

The Role of Family Functioning in Adaptation to Being a Caregiver of an Individual With Rett Syndrome

NCT00891956

COMPLETED

The Nosology and Etiology of Leukodystrophies of Unknown Causes

NCT00889174

COMPLETED

Clinical, Cellular, and Molecular Investigation Into Oculocutaneous Albinism

NCT00808106

COMPLETED

Clinical and Genetic Studies of VACTERL Association

NCT00766571

TERMINATED

Cultural Congruence in International Genetics Research

NCT00767858

COMPLETED

Use of Population Descriptors in Human Genetic Research

NCT00767702

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What the Pipeline for National Human Genome Research Institute (NHGRI) Shows

According to the ClinicalTrials.gov registry, National Human Genome Research Institute (NHGRI) is linked to 185 US clinical trials across every stage of research activity. Of those, 30 studies are currently recruiting, about 16% of the sponsor's indexed portfolio, and 143 are already marked complete, representing roughly 77% of the total.

The phase mix for National Human Genome Research Institute (NHGRI) reports 0 late-stage studies (Phase 3 and Phase 4 combined) and 18 earlier-phase studies (Phase 1 and Phase 2).

The top therapeutic focus area indexed for National Human Genome Research Institute (NHGRI) is Proteus Syndrome with 3 linked trials, and 9 other condition areas appear in the top list above.

How to read these pipeline numbers

Recruiting share is one of the more practical signals here: it reflects how much of a sponsor's research is presently open to new participants, while the completed share indicates the depth of finished work that has already contributed registry results. Both counts come directly from the public ClinicalTrials.gov dataset and are refreshed on the registry side; this page mirrors the latest data pull without altering it.

A portfolio weighted toward Phase 3 usually reflects an organization advancing candidates toward regulatory review, where the research centers on comparative efficacy and broader safety across larger populations. A heavier Phase 1 and Phase 2 tilt generally indicates exploratory work, safety, dosing, and early signal detection, and is common among research-forward sponsors that seed many early programs. Phase 4 entries, when present, track interventions already in real-world use and typically focus on long-term safety, effectiveness across subgroups, or formulation comparisons.

That distribution is a quick read of where the organization concentrates its research attention; it does not imply product availability, market share, or any clinical endorsement. All numbers on this page come from ClinicalTrials.gov maintained by the National Library of Medicine, and counts can shift as new studies are registered or existing ones update their status. This information is provided for reference and educational purposes only, not as medical, investment, or regulatory advice, verify current details directly with ClinicalTrials.gov before relying on any figure here.

Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial from this sponsor, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.