National Human Genome Research Institute (NHGRI)

Compiled by PlainTrial · August 8, 2026

Open enrollment with an early-phase pipeline tilt

According to ClinicalTrials.gov-derived indexes, National Human Genome Research Institute (NHGRI) sits in the top decile of US sponsors by registered trial count (#161 of 15,742 sponsors by registered trial count).

185 total trials 30 currently recruiting 143 completed early-phase tilt top decile by trial count

National Human Genome Research Institute (NHGRI): 185 sponsored US clinical trials, 30 recruiting.

National Human Genome Research Institute (NHGRI) sponsors 185 registered US clinical trials on ClinicalTrials.gov, 30 of them currently recruiting, and 143 completed. 0 of these trials are in Phase 3-4 (later-stage) and 18 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Proteus Syndrome, with 3 trials.

National Human Genome Research Institute (NHGRI) ranks in the top decile of sponsors by registered trial count (#161 of 15,742 sponsors by registered trial count). Volume at this scale usually reflects a long institutional pipeline, read phase tilt and therapeutic areas below before treating it as current-year activity.

Trial completion reliability score

C 75/100

143 of 152 decided trials (Completed vs. Terminated on ClinicalTrials.gov) reached their planned completion (94.1%), vs. national p10 68.4% / p90 100% among 1,234 sponsors with at least 10 decided trials. Still-open trials (Recruiting, Active-not-recruiting, Not-yet-recruiting) are excluded since they have not reached an outcome yet.

Open and recent trials

185 total, page 1 of 4

National Human Genome Research Institute (NHGRI)

Top-decile sponsor footprint

Open and recent trials

Deciphering the Genetic Architecture of Autoimmune Diseases

Observational Study of Advanced Data Analytics in Genetic Conditions

An Open-Label Phase 2 Study of N-Acetyl-D-Mannosamine (ManNAc) in Subjects With Primary Focal Segmental Glomerulosclerosis

Cybersickness Prevention and Mitigation in Virtual Reality for Healthy Volunteers

Study to Understand the Genetic Risk of Developing an Immune Response After Blood Transfusions Among Individuals With Sickle Cell Disease

Childhood-Onset Essential Hypertension Natural History Study

A Natural History Study Seeks to Understand the Clinical, Genomic, Pharmacological, Laboratory, and Dietary Determinates of Pyrimidine and Purine Metabolism Disorders

Caregiving Networks Across Disease Context and the Life Course

MK-7075 (Miransertib) in Proteus Syndrome

Acute Infection in Mitochondrial Disease: Metabolism, Infection and Immunity

IDENTIFY Study: Natural History of Maternal Neoplasia

A Phase 1/2 Study of Intravenous Gene Transfer With an AAV9 Vector Expressing Human Beta-galactosidase in Type I and Type II GM1 Gangliosidosis

Longitudinal Studies of Patient With FPDMM

Natural History, Physiology, Microbiome and Biochemistry Studies of Propionic Acidemia

Clinical and Genetic Evaluation of Individuals With Undiagnosed Disorders Through the Undiagnosed Diseases Network

Genomic Services Research Program

Clinical and Basic Investigations Into Known and Suspected Congenital Disorders of Glycosylation

The NIH MINI Study: Metabolism, Infection, and Immunity in Inborn Errors of Metabolism

A Natural History Study of Patients With GNE Myopathy and GNE-Related Diseases

Genome Medical Sequencing for Gene Discovery

Studies of Skin Microbes in Healthy People and in People With Skin Conditions

Clinical and Laboratory Study of Methylmalonic Acidemia

Study of Chediak-Higashi Syndrome

Natural History of Glycosphingolipid Storage Disorders and Glycoprotein Disorders

Study of Alkaptonuria

Clinical and Basic Investigations Into Hermansky-Pudlak Syndrome

Study of Proteus Syndrome and Related Congenital Disorders

Familial Mediterranean Fever and Related Disorders: Genetics and Disease Characteristics

Use of Cysteamine in the Treatment of Cystinosis

Diagnosis and Treatment of Patients With Inborn Errors of Metabolism

ClinSeq: A Large-Scale Medical Sequencing Clinical Research Pilot Study

Analysis of Specimens From Individuals With Pulmonary Fibrosis

Natural History Study of Smith-Magenis Syndrome

Care Choreographies and the Making of the Psychosocial in Genetic Counseling

Genomics, Environmental Factors and Social Determinants of Cardiovascular Disease in African-Americans Study (GENE-FORECAST): Prospective COVID-19 Natural History Study

Genetic and Social Network Correlates of Rheumatoid Arthritis Outcomes in Hispanic Populations: A Prospective Study

Living With Sickle Cell Disease in the COVID-19 Pandemic

Genetics of COVID-19 Susceptibility and Manifestations

New Approaches for Empowering Studies of Asthma in Populations of African Descent

Mapping Institutional Identities and the Production of Ethics

Adult Patients With Undiagnosed Conditions and Their Responses to Clinically Uncertain Results From Exome Sequencing

Study of People With Generalized Arterial Calcification of Infancy (GACI) or Autosomal Recessive Hypophosphatemic Rickets Type 2 (ARHR2)

Is it Feasible?: Self-Affirmation for Hereditary Breast and Ovarian Cancer Genetic Counseling

Pregnant Women s Views About the Ethics of Prenatal Whole Genome Sequencing

Examining the Knowledge, Attitudes, and Beliefs of Sickle Cell Disease Patients, Parents of Patients With Sickle Cell Disease, and Providers Towards the Integration of CRISPR in Clinical Care

Where Culture Meets Genetics: Exploring Latinas Causal Attributions of Breast and Colon Cancer and Models of Disease Inheritance

New Technology and Child Health

Dose Finding Trial of MK-7075 in Children and Adults With Proteus Syndrome

Are Genetic Counselors Screening for Adolescent Suicide Risk?

Study of Sirolimus Therapy for Segmental Overgrowth Caused by Somatic PI3K Activation

Phase Distribution

Therapeutic Areas

What is open in the National Human Genome Research Institute (NHGRI) pipeline

National Human Genome Research Institute (NHGRI): open-pipeline peers nationwide

Sponsors near 185 trials (± recruiting share)

Sponsors near 16% open enrollment (± trial volume)

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