National Human Genome Research Institute (NHGRI)
National Human Genome Research Institute (NHGRI) sponsors 185 registered US clinical trials on ClinicalTrials.gov, 30 of them currently recruiting, and 143 completed. 0 of these trials are in Phase 3-4 (later-stage) and 18 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Proteus Syndrome, with 3 trials.
Trial Pipeline
185 total, page 1 of 4
Deciphering the Genetic Architecture of Autoimmune Diseases
NCT06948110
Observational Study of Advanced Data Analytics in Genetic Conditions
NCT05657405
An Open-Label Phase 2 Study of N-Acetyl-D-Mannosamine (ManNAc) in Subjects With Primary Focal Segmental Glomerulosclerosis
NCT06664814
Cybersickness Prevention and Mitigation in Virtual Reality for Healthy Volunteers
NCT06552754
Study to Understand the Genetic Risk of Developing an Immune Response After Blood Transfusions Among Individuals With Sickle Cell Disease
NCT06944067
Childhood-Onset Essential Hypertension Natural History Study
NCT06778239
A Natural History Study Seeks to Understand the Clinical, Genomic, Pharmacological, Laboratory, and Dietary Determinates of Pyrimidine and Purine Metabolism Disorders
NCT06092346
Caregiving Networks Across Disease Context and the Life Course
NCT05007990
MK-7075 (Miransertib) in Proteus Syndrome
NCT04316546
Acute Infection in Mitochondrial Disease: Metabolism, Infection and Immunity
NCT04419870
IDENTIFY Study: Natural History of Maternal Neoplasia
NCT04049604
A Phase 1/2 Study of Intravenous Gene Transfer With an AAV9 Vector Expressing Human Beta-galactosidase in Type I and Type II GM1 Gangliosidosis
NCT03952637
Longitudinal Studies of Patient With FPDMM
NCT03854318
Natural History, Physiology, Microbiome and Biochemistry Studies of Propionic Acidemia
NCT02890342
Clinical and Genetic Evaluation of Individuals With Undiagnosed Disorders Through the Undiagnosed Diseases Network
NCT02450851
Genomic Services Research Program
NCT02595957
Clinical and Basic Investigations Into Known and Suspected Congenital Disorders of Glycosylation
NCT02089789
The NIH MINI Study: Metabolism, Infection, and Immunity in Inborn Errors of Metabolism
NCT01780168
A Natural History Study of Patients With GNE Myopathy and GNE-Related Diseases
NCT01417533
Genome Medical Sequencing for Gene Discovery
NCT01087320
Studies of Skin Microbes in Healthy People and in People With Skin Conditions
NCT00605878
Clinical and Laboratory Study of Methylmalonic Acidemia
NCT00078078
Study of Chediak-Higashi Syndrome
NCT00005917
Natural History of Glycosphingolipid Storage Disorders and Glycoprotein Disorders
NCT00029965
Study of Alkaptonuria
NCT00005909
Clinical and Basic Investigations Into Hermansky-Pudlak Syndrome
NCT00001456
Study of Proteus Syndrome and Related Congenital Disorders
NCT00001403
Familial Mediterranean Fever and Related Disorders: Genetics and Disease Characteristics
NCT00001373
Use of Cysteamine in the Treatment of Cystinosis
NCT00359684
Diagnosis and Treatment of Patients With Inborn Errors of Metabolism
NCT00369421
ClinSeq: A Large-Scale Medical Sequencing Clinical Research Pilot Study
NCT00410241
Analysis of Specimens From Individuals With Pulmonary Fibrosis
NCT00084305
Natural History Study of Smith-Magenis Syndrome
NCT00013559
Care Choreographies and the Making of the Psychosocial in Genetic Counseling
NCT06280833
Genomics, Environmental Factors and Social Determinants of Cardiovascular Disease in African-Americans Study (GENE-FORECAST): Prospective COVID-19 Natural History Study
NCT05484882
Genetic and Social Network Correlates of Rheumatoid Arthritis Outcomes in Hispanic Populations: A Prospective Study
NCT05457816
Living With Sickle Cell Disease in the COVID-19 Pandemic
NCT04417673
Genetics of COVID-19 Susceptibility and Manifestations
NCT04371432
New Approaches for Empowering Studies of Asthma in Populations of African Descent
NCT03937804
Mapping Institutional Identities and the Production of Ethics
NCT03983863
Adult Patients With Undiagnosed Conditions and Their Responses to Clinically Uncertain Results From Exome Sequencing
NCT03605004
Study of People With Generalized Arterial Calcification of Infancy (GACI) or Autosomal Recessive Hypophosphatemic Rickets Type 2 (ARHR2)
NCT03478839
Is it Feasible?: Self-Affirmation for Hereditary Breast and Ovarian Cancer Genetic Counseling
NCT03225170
Pregnant Women s Views About the Ethics of Prenatal Whole Genome Sequencing
NCT03105492
Examining the Knowledge, Attitudes, and Beliefs of Sickle Cell Disease Patients, Parents of Patients With Sickle Cell Disease, and Providers Towards the Integration of CRISPR in Clinical Care
NCT03167450
Where Culture Meets Genetics: Exploring Latinas Causal Attributions of Breast and Colon Cancer and Models of Disease Inheritance
NCT02767986
New Technology and Child Health
NCT02622035
Dose Finding Trial of MK-7075 in Children and Adults With Proteus Syndrome
NCT02594215
Are Genetic Counselors Screening for Adolescent Suicide Risk?
NCT02486120
Study of Sirolimus Therapy for Segmental Overgrowth Caused by Somatic PI3K Activation
NCT02428296
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 11 |
| Phase 2 | 7 |
Therapeutic Areas
What the Pipeline for National Human Genome Research Institute (NHGRI) Shows
According to the ClinicalTrials.gov registry, National Human Genome Research Institute (NHGRI) is linked to 185 US clinical trials across every stage of research activity. Of those, 30 studies are currently recruiting, about 16% of the sponsor's indexed portfolio, and 143 are already marked complete, representing roughly 77% of the total.
The phase mix for National Human Genome Research Institute (NHGRI) reports 0 late-stage studies (Phase 3 and Phase 4 combined) and 18 earlier-phase studies (Phase 1 and Phase 2).
The top therapeutic focus area indexed for National Human Genome Research Institute (NHGRI) is Proteus Syndrome with 3 linked trials, and 9 other condition areas appear in the top list above.
How to read these pipeline numbers
Recruiting share is one of the more practical signals here: it reflects how much of a sponsor's research is presently open to new participants, while the completed share indicates the depth of finished work that has already contributed registry results. Both counts come directly from the public ClinicalTrials.gov dataset and are refreshed on the registry side; this page mirrors the latest data pull without altering it.
A portfolio weighted toward Phase 3 usually reflects an organization advancing candidates toward regulatory review, where the research centers on comparative efficacy and broader safety across larger populations. A heavier Phase 1 and Phase 2 tilt generally indicates exploratory work, safety, dosing, and early signal detection, and is common among research-forward sponsors that seed many early programs. Phase 4 entries, when present, track interventions already in real-world use and typically focus on long-term safety, effectiveness across subgroups, or formulation comparisons.
That distribution is a quick read of where the organization concentrates its research attention; it does not imply product availability, market share, or any clinical endorsement. All numbers on this page come from ClinicalTrials.gov maintained by the National Library of Medicine, and counts can shift as new studies are registered or existing ones update their status. This information is provided for reference and educational purposes only, not as medical, investment, or regulatory advice, verify current details directly with ClinicalTrials.gov before relying on any figure here.
Read our methodology - how this data is sourced, computed, and verified.
Related
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial from this sponsor, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.