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NCT00889174 · ClinicalTrials.gov registry record
The Nosology and Etiology of Leukodystrophies of Unknown Causes
A clinical trial, sponsored by National Human Genome Research Institute (NHGRI).
- Completed
- Registry status
- 76
- Enrollment target
NCT00889174: Completed study, sponsored by National Human Genome Research Institute (NHGRI).
NCT00889174 is a clinical trial that has completed, run by National Human Genome Research Institute (NHGRI). The registered enrollment target is 76 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00889174 has completed, sponsored by National Human Genome Research Institute (NHGRI).
- COMPLETED
- Registry status
- 76 participants
- Enrollment target
Study Summary
Background: \- A leukodystrophy is a disease affecting the white matter of the brain. The white matter conducts electricity from one part of the brain to the other. If the insulation, or myelin, is damaged, the brain s electrical pathways will not work properly. Researchers are trying to identify what causes leukodystrophy. Objectives: * To collect detailed clinical characterizations, including histories, physical examinations, biochemical tests, genetic studies, and neurophysiologic and neuroimaging studies in patients with unclassified leukodystrophies to comprehensively characterize such patients and obtain comparative clinical profiles. * To collect detailed clinical characterizations, including histories, physical examinations, biochemical tests, genomic and proteomic tissue, and neurophysiologic and neuroimaging studies in patients with known leukodystrophies to investigate the underlying pathogenesis of these disorders. * To better understand leukodystrophies of unknown cause and to identify the part of the DNA of the patient with leukodystrophy that is causing the problem. Eligibility: * Any individual with a known or suspected leukodystrophy is eligible to participate in this protocol, including * Patients with white matter disease that is unclassified or of unknown cause, including but not limited to leukoencephalopathies with calcifications, leukoencephalopathies with cysts, leukoencephalopathies with hypomyelination, and leukoencephalopathies with brainstem involvement. * Parents or siblings of these subjects. * Exclusion criteria include patients too ill to travel to the Clinical Center and patients for whom the leukoencephalopathy is felt to be secondary to an acquired cause (for example, traumatic or infectious). Design: * Patients will be seen either as an inpatient or outpatient depending on the tests that are planned. Patients may need to stay at the Clinical Center for 3 to 5 days. * The following tests will be conducted as part of sta
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 76 participants |
| Start Date | 2009-04-24 |
| Est. Completion | 2018-08-01 |
What the finished NCT00889174 record still lists
NCT00889174 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 76 participants, a relatively small participant target.
The record links to 0 conditions, and to 0 interventions.
NCT00889174 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00889174 about?
NCT00889174 is a clinical study titled "The Nosology and Etiology of Leukodystrophies of Unknown Causes". Background: \- A leukodystrophy is a disease affecting the white matter of the brain. The white matter conducts electricity from one part of the brain to the other. If the insulation, or myelin, is damaged, the brain s electrical pathways will not work properly. Researchers are trying to identify w...
What is the current status of trial NCT00889174?
This trial is currently completed. The enrollment target is 76 participants. The study started on 2009-04-24. Estimated completion is 2018-08-01.
Who is sponsoring clinical trial NCT00889174?
This trial is sponsored by National Human Genome Research Institute (NHGRI), which has 185 total clinical trials registered on ClinicalTrials.gov.
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