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NCT06948110 · ClinicalTrials.gov registry record
Deciphering the Genetic Architecture of Autoimmune Diseases
A clinical trial of Autoimmune Diseases, sponsored by National Human Genome Research Institute (NHGRI).
- Recruiting
- Registry status
- 300
- Enrollment target
- 2
- Study locations
NCT06948110: Recruiting study of Autoimmune Diseases, sponsored by National Human Genome Research Institute (NHGRI).
NCT06948110 is a study of Autoimmune Diseases that is actively recruiting participants, run by National Human Genome Research Institute (NHGRI). The registered enrollment target is 300 participants, below the 966-participant average among 25 other Autoimmune Diseases trials with a reported enrollment target (69% lower). The trial reports 2 study locations across 2 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06948110, a study of Autoimmune Diseases, is actively recruiting participants, sponsored by National Human Genome Research Institute (NHGRI).
- RECRUITING
- Registry status
- 300 participants
- Enrollment target
- 2
- Study locations
Study Summary
Background: Autoimmune diseases can be caused by genes people inherit from their parents. The gene changes that cause these diseases have been well studied in people with European and Asian ancestors. But some diseases behave differently in people who are native to North and South America. Researchers want to know more about the gene changes and other factors that may cause autoimmune diseases among these people. This project will be based in Peru. Objective: To study how gene changes can lead to autoimmune diseases in people native to Peru. Eligibility: People aged 18 years and older with an autoimmune disease. These may include systemic lupus erythematosus; Sjogren disease; scleroderma; rheumatoid arthritis; seronegative spondylo-arthropathies; and systemic vasculitis. Family members and healthy volunteers are also needed. Design: Participants will have 2 clinic visits; these will be 2 weeks apart. The clinics will be in Lima, Iquitos, and other sites in Peru. Visit 1: Participants will have a physical exam. They will answer questions about their health risks and habits. They will provide blood and urine samples. Visit 2: Participants will provide a second blood sample and a stool sample. They will talk about the results of their first clinical exam with researchers. The cost of travel to and from the clinics will be provided. Participants will get $30 per visit and a snack.
Primary Outcome
Successful recruitment and whole-genome sequencing of at least 20 multiplex families with high familial autoimmunity burden, enabling identification and preliminary annotation of rare or novel genetic variants potentially linked to autoimmune disease susceptibility.
Conditions Studied
Study Locations (2)
Maryland
- National Human Genome Research Institute (NHGRI) - Bethesda
Other
- Amazon Rainforest - Lima
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 300 participants |
| Start Date | 2026-03-26 |
| Est. Completion | 2030-04-22 |
What NCT06948110 shows while recruiting
NCT06948110 is an observational study that tracks outcomes without assigning an intervention. The registered 300 participants enrollment target is mid-sized for trials with a published cap, below the 966-participant average among 25 other Autoimmune Diseases trials with a reported enrollment target (69% lower).
The record links to 1 condition, with Autoimmune Diseases appearing as the primary indexed condition, and to 0 interventions.
NCT06948110 reports a single indexed study location in Maryland, Other.
Frequently Asked Questions
What is clinical trial NCT06948110 about?
NCT06948110 is a clinical study titled "Deciphering the Genetic Architecture of Autoimmune Diseases". Background: Autoimmune diseases can be caused by genes people inherit from their parents. The gene changes that cause these diseases have been well studied in people with European and Asian ancestors. But some diseases behave differently in people who are native to North and South America. Research...
What is the current status of trial NCT06948110?
This trial is currently recruiting. The enrollment target is 300 participants. The study started on 2026-03-26. Estimated completion is 2030-04-22.
What conditions does trial NCT06948110 study?
This clinical trial studies the following conditions: Autoimmune Diseases.
Who is sponsoring clinical trial NCT06948110?
This trial is sponsored by National Human Genome Research Institute (NHGRI), which has 185 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06948110 being conducted?
This trial has 2 study locations across Maryland. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Autoimmune Diseases
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06948110's enrollment target sits among peer trials
300 11th of 25 higher than 14 of 25 other Autoimmune Diseases trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Autoimmune Diseases trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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