Massachusetts General Hospital
Open enrollment with an early-phase pipeline tilt
According to ClinicalTrials.gov-derived indexes, Massachusetts General Hospital sits in the top decile of US sponsors by registered trial count (#4 of 15,742 sponsors by registered trial count).
Massachusetts General Hospital: 2,032 sponsored US clinical trials, 336 recruiting.
Massachusetts General Hospital sponsors 2,032 registered US clinical trials on ClinicalTrials.gov, 336 of them currently recruiting, and 1,284 completed. 240 of these trials are in Phase 3-4 (later-stage) and 515 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Depression, with 29 trials.
Top-decile sponsor footprint
Massachusetts General Hospital ranks in the top decile of sponsors by registered trial count (#4 of 15,742 sponsors by registered trial count). Volume at this scale usually reflects a long institutional pipeline, read phase tilt and therapeutic areas below before treating it as current-year activity.
Trial completion reliability score
1,284 of 1,487 decided trials (Completed vs. Terminated on ClinicalTrials.gov) reached their planned completion (86.3%), vs. national p10 68.4% / p90 100% among 1,234 sponsors with at least 10 decided trials. Still-open trials (Recruiting, Active-not-recruiting, Not-yet-recruiting) are excluded since they have not reached an outcome yet.
Open and recent trials
2,032 total, page 2 of 41
Effect of Intravenous and Topical Tranexamic Acid on Drain Output in Breast Reduction Surgery
NCT07131592
The Association Between Gut Microbiota Diversity and Postpartum Depression
NCT07227753
Pilot Study of a Behavioral Program for Resident Depression in Skilled Nursing Facilities
NCT07655232
45th Multicenter Airway Research Collaboration
NCT07166939
Behavioral Health Program for Short-Stay Nursing Facility Residents & Care Partners
NCT07220486
Effect of Tirzepatide and Bimagrumab on Body Composition, Insulin Sensitivity, and Bone in Adults With Obesity
NCT05933499
Effect of Mindfulness-based Neurofeedback for Adolescents With Elevated Repetitive Negative Thinking
NCT07055217
The PREGNANT (Pregnant Resident Empowerment, GuidaNce, and Advocacy iN Training) Coaching Project
NCT07221422
Well-being in IBS: Strengths and Happiness (WISH) 2.0
NCT06866106
Optimizing Care Transition Process for Older Colorectal Surgery Patients
NCT06752031
Mind-body Resilience Program for Cardiac Arrest Survivors and Their Caregivers: Recovering Together After Cardiac Arrest
NCT07143357
Spironolactone to Improve Pregnancy-Associated Hypertension Trajectories
NCT07041281
Cognitive Rehabilitation for Refugees With Traumatic Brain Injury and Cognitive Impairment
NCT06839079
Impact of Disclosing Coronary Artery Disease Polygenic Risk Score on Cardiovascular Health
NCT07087431
Impact of Earplugs on Mechanisms of Noise-Related Cardiovascular Disease
NCT07148817
Precision Biomarkers to Detect Brain Injury in Active-Duty United States Special Operations Forces With Repeated Blast Exposure
NCT07131475
Pain Disengagement Training (Open Pilot)
NCT06870162
Ivonescimab in Comb. With FOLFOX in Advanced HER2 Neg. GEA
NCT07070466
Prehabilitation for Aortic Aneurysm Surgery: Proof-of-concept Trial
NCT06998498
Substrates for Post-Stroke Arm Rehabilitation
NCT06998485
Two Post-Operative Pain Protocols at Discharge for Orthopaedic Patients
NCT07265557
PDAC-PATHWAYS: A Digital Informational and Supportive Care App for Patients Initiating Neoadjuvant Therapy for Pancreatic Ductal Adenocarcinoma
NCT07047807
Personalized Risk Estimation for Crohn's Disease (PRE-Crohn's): Implementation and Feasibility
NCT05332639
Targeted Palliative Care Intervention for Patients With Metastatic Breast Cancer
NCT06795529
BRIDGE: Blood Pressure Reduction and Intervention Delivery Via Group Engagement
NCT07091851
Pain Outcomes After Digital Amputation Using Tulavi Allay™ Nerve Cap
NCT06915662
Feasibility Testing of the "Face-Forward-Web" Program for Chronic Orofacial Pain
NCT06754917
Diet and Stress Management Combined With Advanced Therapy for Crohn's and Ulcerative Colitis
NCT07168499
Comparing the Efficacy of Heated Yoga and Sauna as a Treatment for Depression
NCT07082998
Online Parent Education for Child Anxiety
NCT07153250
Mindfulness-based Cognitive Therapy vs the Health Enhancement Program for Chronic Pain and Depression; The Quiet Focus Study
NCT07118722
Modulation Effect of tACS on Chronic Low Back Pain
NCT06568198
Towards Testing the Effectiveness of Recovery Community Centers (RCCs)
NCT07010978
ELISA in Relapsed/Refractory MM
NCT06832865
Multidisciplinary Intervention for Adults With Chronic Graft-versus-host Disease
NCT06910969
Building Connections
NCT07091032
Facilitation of Extinction Retention and Reconsolidation Blockade by IV Allopregnanolone in PTSD.
NCT07079761
Mindfulness and Behavior Change to Improve Cardiovascular Health of Older People With HIV
NCT06001814
HepHospital: A Pilot Trial of a Hepatology Home Hospital Intervention for Patients With Advanced Liver Disease
NCT05205954
Tesamorelin as an Adjunct to Exercise for Improving Physical Function in HIV
NCT06554717
Omalizumab Weight-Based Dosing Efficacy Trial
NCT06943534
Researching Heat and Yoga for Mood Enhancement
NCT06094088
Behavioral Intervention for Youth to Promote Vaping Cessation
NCT06765291
CRC Screening in Unscreened Individuals 45-54
NCT06757192
Positive Fit to Colonoscopy: Closing the Gap
NCT06763432
Outpatient Epcoritamab as 2L in NTE R/R DLBCL
NCT06811272
Feasibility of a Wireless Thermal Capsule Endoscopy to Detect Gastrointestinal Thermal Variance
NCT07033208
Assessing Tenapanor as a Treatment of CF-related Constipation.
NCT06810167
Facilitated Transitions From Postpartum to Primary Care Coordination for People With Chronic Conditions
NCT06557005
Flotufolastat F 18 PET in Men With Very Low PSA Recurrence
NCT06862856
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 226 |
| Phase 2 | 289 |
| Phase 3 | 58 |
| Phase 4 | 182 |
Therapeutic Areas
What is open in the Massachusetts General Hospital pipeline
336 recruiting of 2,032 indexed (17% open); 1,284 completed (63%).
Phase mix: 240 late (III/IV) vs 515 early (I/II) (early-phase heavy).
Top condition: Depression (29 trials), 9 others listed.
How open-pipeline share is computed
Recruiting share is recruiting_count divided by trial_count for this sponsor in the public registry export. Status can change between pulls; treat the figure as a research-attention snapshot, not product availability.
Massachusetts General Hospital: open-pipeline peers nationwide
Peers matched on 2,032 registered trials and 17% open enrollment, not the therapeutic-area sidebar.
Massachusetts General Hospital sits at or above the median trial volume and below the median recruiting share among these 9 nationwide peers -- the two do not always move together.
Sponsors near 2,032 trials (± recruiting share)
- National Institute of Allergy and Infectious Diseases (NIAID) · 2,006 trials · 8% recruiting
- Memorial Sloan Kettering Cancer Center · 1,884 trials · 17% recruiting
- Pfizer · 1,845 trials · 6% recruiting
- Stanford University · 1,744 trials · 15% recruiting
Sponsors near 17% open enrollment (± trial volume)
- Rush University Medical Center · 17% recruiting · 320 trials
- OHSU Knight Cancer Institute · 17% recruiting · 211 trials
- Adagene · 17% recruiting · 6 trials
- Agendia · 17% recruiting · 6 trials
Related
What to do with this Massachusetts General Hospital page
2,032 registered trials is a research-attention snapshot, not an endorsement of Massachusetts General Hospital or any single study.
- 336 of Massachusetts General Hospital's trials are currently recruiting, check each one's own eligibility criteria before contacting a site. Browse recruiting trials
- Depression is the condition Massachusetts General Hospital studies most, compare against other sponsors active in the same condition before evaluating a specific study. See Depression trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. Massachusetts General Hospital pipeline card: 2,032 registered trials from official public datasets. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.