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NCT07055217 · ClinicalTrials.gov registry record · NA
Effect of Mindfulness-based Neurofeedback for Adolescents With Elevated Repetitive Negative Thinking
A NA study of Neurofeedback and Repetitive Negative Thinking, sponsored by Massachusetts General Hospital.
- Recruiting
- Registry status
- NA
- Development phase
- 100
- Enrollment target
- 1
- Study location
NCT07055217: Recruiting NA study of Neurofeedback and Repetitive Negative Thinking, sponsored by Massachusetts General Hospital.
NCT07055217 is a NA study of Neurofeedback and Repetitive Negative Thinking that is actively recruiting participants, run by Massachusetts General Hospital. The registered enrollment target is 100 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (93% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07055217, a NA study of Neurofeedback and Repetitive Negative Thinking, is actively recruiting participants, sponsored by Massachusetts General Hospital.
- RECRUITING
- Registry status
- NA
- Development phase
- 100 participants
- Enrollment target
- 1
- Study location
Study Summary
This study will test the hypotheses that adolescent with repetitive negative thinking who at at-risk for serious mental illness will show greater default mode network (DMN) connectivity than healthy controls, at-risk adolescents will show greater changes in DMN connectivity than healthy controls, and that a longer session of mindfulness based neurofeedback will lead to greater reduction in DMN connectivity. To do so, 50 adolescents with elevated repetitive negative thinking and 50 matched healthy control participants will be enrolled into a double-blind randomized clinical trial of a session of mindfulness training with either active mindfulness-basde neurofeedback or sham mindfulness-based neurofeedback.
Primary Outcome
We will test whether at-risk adolescents have higher default mode network (DMN) functional connectivity (i.e., hyperconnectivity) compared to healthy control participants. A matched-sample t-test will examine baseline functional connectivity between two canonical DMN nodes (personalized medial prefrontal cortex and posterior cingulate cortex).
Conditions Studied
Interventions
- BEHAVIORAL Mindfulness Training
- BEHAVIORAL Mindfulness-based Neurofeedback (Real mbNF)
- BEHAVIORAL Sham mindfulness-based neurofeedback (Sham mbNF)
Study Locations (1)
Massachusetts
- Massachusetts General Hospital, Center for Addiction Medicine, 101 Merrimac Street, Suite 320, Boston, MA 02114 - Boston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 100 participants |
| Start Date | 2025-11-04 |
| Est. Completion | 2027-04 |
| Phase | NA |
What NCT07055217 shows while recruiting
NCT07055217 is an interventional study that assigns participants to a tested intervention. The registered 100 participants enrollment target is mid-sized for trials with a published cap, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (93% lower).
The record links to 2 conditions, with Neurofeedback appearing as the primary indexed condition, and to 3 interventions - of which Mindfulness Training is the first listed.
NCT07055217 reports a single indexed study location in Massachusetts.
Frequently Asked Questions
What is clinical trial NCT07055217 about?
NCT07055217 is a clinical study titled "Effect of Mindfulness-based Neurofeedback for Adolescents With Elevated Repetitive Negative Thinking". This study will test the hypotheses that adolescent with repetitive negative thinking who at at-risk for serious mental illness will show greater default mode network (DMN) connectivity than healthy controls, at-risk adolescents will show greater changes in DMN connectivity than healthy controls, an...
What is the current status of trial NCT07055217?
This trial is currently recruiting. It is a NA study. The enrollment target is 100 participants. The study started on 2025-11-04. Estimated completion is 2027-04.
What conditions does trial NCT07055217 study?
This clinical trial studies the following conditions: Neurofeedback, Repetitive Negative Thinking.
What interventions are being tested in trial NCT07055217?
The interventions under investigation include: Mindfulness Training (BEHAVIORAL), Mindfulness-based Neurofeedback (Real mbNF) (BEHAVIORAL), Sham mindfulness-based neurofeedback (Sham mbNF) (BEHAVIORAL).
Who is sponsoring clinical trial NCT07055217?
This trial is sponsored by Massachusetts General Hospital, which has 2,032 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07055217 being conducted?
This trial has 1 study location across Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT07055217's enrollment target sits among peer trials
100 840th of 2000 higher than 1,081 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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