Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT07227753 · ClinicalTrials.gov registry record
The Association Between Gut Microbiota Diversity and Postpartum Depression
A clinical trial of Depression During Pregnancy, sponsored by Massachusetts General Hospital.
- Recruiting
- Registry status
- 30
- Enrollment target
- 1
- Study location
NCT07227753: Recruiting study of Depression During Pregnancy, sponsored by Massachusetts General Hospital.
NCT07227753 is a study of Depression During Pregnancy that is actively recruiting participants, run by Massachusetts General Hospital. The registered enrollment target is 30 participants. The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07227753, a study of Depression During Pregnancy, is actively recruiting participants, sponsored by Massachusetts General Hospital.
- RECRUITING
- Registry status
- 30 participants
- Enrollment target
- 1
- Study location
Study Summary
This study aims to examine whether naturally occurring bacteria in the gastrointestinal tract are associated with mood changes following childbirth, including postpartum depression. Biological samples will be collected before and after delivery to determine whether specific patterns in gut bacterial composition are linked to emotional states. The purpose of the research is to improve understanding of whether such microbial changes can help identify individuals at higher risk for postpartum depression, enabling earlier recognition and intervention.
Primary Outcome
Compare gut microbiota composition between participants with postpartum depression (defined as Edinburgh Postnatal Depression Scale (EPDS; range 0-30; higher scores indicate more depressive symptoms) ≥13) and without postpartum depression (EPDS \<13).
Conditions Studied
Study Locations (1)
Massachusetts
- Meikun Wang - Boston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 30 participants |
| Start Date | 2025-11-17 |
| Est. Completion | 2026-05 |
What NCT07227753 shows while recruiting
NCT07227753 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 30 participants, a relatively small participant target.
The record links to 1 condition, with Depression During Pregnancy appearing as the primary indexed condition, and to 0 interventions.
NCT07227753 reports a single indexed study location in Massachusetts.
Frequently Asked Questions
What is clinical trial NCT07227753 about?
NCT07227753 is a clinical study titled "The Association Between Gut Microbiota Diversity and Postpartum Depression". This study aims to examine whether naturally occurring bacteria in the gastrointestinal tract are associated with mood changes following childbirth, including postpartum depression. Biological samples will be collected before and after delivery to determine whether specific patterns in gut bacterial...
What is the current status of trial NCT07227753?
This trial is currently recruiting. The enrollment target is 30 participants. The study started on 2025-11-17. Estimated completion is 2026-05.
What conditions does trial NCT07227753 study?
This clinical trial studies the following conditions: Depression During Pregnancy.
Who is sponsoring clinical trial NCT07227753?
This trial is sponsored by Massachusetts General Hospital, which has 2,032 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07227753 being conducted?
This trial has 1 study location across Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Depression During Pregnancy
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT00977977 · 30 participants · Phase 2
Rituximab Plus Cyclosporine in Idiopathic Membranous Nephropathy
- NCT01459107 · 30 participants · Phase 2
Human Upper Extremity Allotransplantation
- NCT01666080 · 30 participants · NA
Second or Greater Allogeneic Hematopoietic Stem Cell Transplant Using Reduced Intensity Conditioning (RIC)
- NCT01720836 · 30 participants · Phase 1
Study of the Immune Response of MUC1 (Mucin1) Peptide Vaccine for Non-small Cell Lung Cancer
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI