Duke University

Open enrollment with an early-phase pipeline tilt

According to ClinicalTrials.gov-derived indexes, Duke University sits in the top decile of US sponsors by registered trial count (#9 of 15,742 sponsors by registered trial count).

1,725 total trials 187 currently recruiting 1244 completed early-phase tilt top decile by trial count

Duke University: 1,725 sponsored US clinical trials, 187 recruiting.

Duke University sponsors 1,725 registered US clinical trials on ClinicalTrials.gov, 187 of them currently recruiting, and 1,244 completed. 175 of these trials are in Phase 3-4 (later-stage) and 311 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Obesity, with 15 trials.

Top-decile sponsor footprint

Duke University ranks in the top decile of sponsors by registered trial count (#9 of 15,742 sponsors by registered trial count). Volume at this scale usually reflects a long institutional pipeline, read phase tilt and therapeutic areas below before treating it as current-year activity.

Trial completion reliability score

D 55/100

1,244 of 1,444 decided trials (Completed vs. Terminated on ClinicalTrials.gov) reached their planned completion (86.1%), vs. national p10 68.4% / p90 100% among 1,234 sponsors with at least 10 decided trials. Still-open trials (Recruiting, Active-not-recruiting, Not-yet-recruiting) are excluded since they have not reached an outcome yet.

Open and recent trials

1,725 total, page 35 of 35

COMPLETED Phase 1

Carmustine Plus O(6)-Benzylguanine in Treating Patients With Recurrent or Progressive Gliomas of the Brain

NCT00003348

COMPLETED Phase 1

Intrathecal Busulfan in Treating Patients With Recurrent, Refractory, or Metastatic Leptomeningeal Tumors

NCT00003462

COMPLETED Phase 2

Temozolomide in Treating Patients With Progressive Low-Grade Glioma

NCT00003466

COMPLETED Phase 2

Temozolomide in Treating Patients With Anaplastic Oligodendroglioma

NCT00003465

COMPLETED Phase 1

Radiolabeled Monoclonal Antibody Therapy in Treating Patients With Primary or Metastatic Brain Tumors

NCT00003461

COMPLETED Phase 2

Carmustine in Treating Adults With Recurrent Supratentorial Low-Grade Glioma

NCT00003467

COMPLETED

Determination of the Prevalence and Prognostic Importance of Unrecognized Non-Q-wave Myocardial Infarction by MRI

NCT00493168

COMPLETED Phase 1

Radiolabeled Monoclonal Antibody Therapy in Treating Patients With Primary Brain Tumors

NCT00003478

COMPLETED Phase 2

Temozolomide in Treating Adults With Newly Diagnosed Primary Malignant Glioblastoma Multiforme

NCT00003464

COMPLETED Phase 1

LMB-7 Immunotoxin in Treating Patients With Leptomeningeal Metastases

NCT00003020

COMPLETED Phase 1

Vaccine Therapy in Treating Patients With Metastatic Melanoma Who Are Undergoing Surgery for Lymph Node and Tumor Removal

NCT00003229

COMPLETED Phase 1

Irinotecan Plus Carmustine in Treating Patients With Recurrent Primary Malignant Glioma

NCT00002988

COMPLETED Phase 1

Chemotherapy in Treating Patients With Recurrent Malignant Glioma

NCT00002986

COMPLETED Phase 1

Biological Therapy in Treating Patients With Metastatic Cancer

NCT00004604

COMPLETED

Genetic Study in Patients Receiving Treatment for Hodgkin's Disease or Childhood Brain Tumor

NCT00006342

COMPLETED

Neurocognitive Outcomes of Depression in the Elderly

NCT00570583

COMPLETED

Genetics of Spina Bifida and Anencephaly

NCT00636233

COMPLETED Phase 1

Radiolabeled Monoclonal Antibody Therapy in Treating Patients With Primary or Metastatic Brain Cancers

NCT00002752

COMPLETED Phase 2

Carboplatin in Patients With Progressive Gliomas

NCT00002749

COMPLETED Phase 1

Monoclonal Antibody Therapy in Treating Patients With Primary or Metastatic Melanoma or Brain Tumors

NCT00002754

COMPLETED Phase 1

Melphalan in Patients With Neoplastic Meningitis

NCT00002750

COMPLETED Phase 1

Monoclonal Antibody Therapy in Treating Patients With Recurrent Gliomas

NCT00002753

COMPLETED Phase 1

Monoclonal Antibody Therapy in Treating Patients With Brain Metastases

NCT00002751

COMPLETED

Duke Urology Database and Specimen Bank

NCT00978991

COMPLETED NA

Improved Patient Handoffs to Prevent Sentinel Events

NCT01855646

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Phase Distribution

PhaseTrial count
Phase 1 136
Phase 2 175
Phase 3 41
Phase 4 134

What is open in the Duke University pipeline

187 recruiting of 1,725 indexed (11% open); 1,244 completed (72%).

Phase mix: 175 late (III/IV) vs 311 early (I/II) (early-phase heavy).

Top condition: Obesity (15 trials), 9 others listed.

How open-pipeline share is computed

Recruiting share is recruiting_count divided by trial_count for this sponsor in the public registry export. Status can change between pulls; treat the figure as a research-attention snapshot, not product availability.

Duke University: open-pipeline peers nationwide

Peers matched on 1,725 registered trials and 11% open enrollment, not the therapeutic-area sidebar.

Duke University sits at or above the median trial volume and at or above the median recruiting share among these 9 nationwide peers -- the two do not always move together. Source: ClinicalTrials.gov (2026-08-08 snapshot). 2×2 strategic matrix plotting 9 entities by Total trials (X) and Recruiting share (Y), with a crosshair dividing the plot into four quadrants. Higher volume & more openFocused & more openHigher volume, mostly closedSmaller & mostly closed 05001,0001,5002,000 5%10%15%20% Total trials Recruiting share Duke UniversityUniversity of California, San FranciscoStanford UniversityVA Office of Research and DevelopmentPfizerCarnegie Mellon UniversityCAMC Health SystemUConn HealthHartford Hospital
Duke University sits at or above the median trial volume and at or above the median recruiting share among these 9 nationwide peers -- the two do not always move together. Source: ClinicalTrials.gov (2026-08-08 snapshot).

Duke University sits at or above the median trial volume and at or above the median recruiting share among these 9 nationwide peers -- the two do not always move together.

Sponsors near 1,725 trials (± recruiting share)

Sponsors near 11% open enrollment (± trial volume)

What to do with this Duke University page

1,725 registered trials is a research-attention snapshot, not an endorsement of Duke University or any single study.

  • 187 of Duke University's trials are currently recruiting, check each one's own eligibility criteria before contacting a site. Browse recruiting trials
  • Obesity is the condition Duke University studies most, compare against other sponsors active in the same condition before evaluating a specific study. See Obesity trials
  • Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide

Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.

Duke University pipeline card: 1,725 registered trials from official public datasets.Report a data error.