Duke University

Compiled by PlainTrial · August 8, 2026

Open enrollment with an early-phase pipeline tilt

According to ClinicalTrials.gov-derived indexes, Duke University sits in the top decile of US sponsors by registered trial count (#9 of 15,742 sponsors by registered trial count).

1,725 total trials 187 currently recruiting 1244 completed early-phase tilt top decile by trial count

Duke University: 1,725 sponsored US clinical trials, 187 recruiting.

Duke University sponsors 1,725 registered US clinical trials on ClinicalTrials.gov, 187 of them currently recruiting, and 1,244 completed. 175 of these trials are in Phase 3-4 (later-stage) and 311 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Obesity, with 15 trials.

Duke University ranks in the top decile of sponsors by registered trial count (#9 of 15,742 sponsors by registered trial count). Volume at this scale usually reflects a long institutional pipeline, read phase tilt and therapeutic areas below before treating it as current-year activity.

Trial completion reliability score

D 55/100

1,244 of 1,444 decided trials (Completed vs. Terminated on ClinicalTrials.gov) reached their planned completion (86.1%), vs. national p10 68.4% / p90 100% among 1,234 sponsors with at least 10 decided trials. Still-open trials (Recruiting, Active-not-recruiting, Not-yet-recruiting) are excluded since they have not reached an outcome yet.

Open and recent trials

1,725 total, page 27 of 35

Duke University

Top-decile sponsor footprint

Open and recent trials

ENLIGHTEN: Exercise and NutritionaL Interventions for coGnitive and Cardiovascular HealTh ENhancement

Isolation of Circulating Tumor Cells Using a Novel EMT-Based Capture Method

Magnetic Resonance Imaging (MRI) in Motion

Personalized Diabetic Kidney Disease Risk Info to Initiate and Maintain Health Behavior Changes

Prospective Randomized Evaluation of a Two and Three Piece Total Ankle Replacement

Vasospasm in Pediatric Traumatic Brain Injury

New Therapy for Patients With Severe Tinnitus

Identifying the Genetic Predictors of Severe Acne Vulgaris and the Outcome of Oral Isotretinoin Treatment

Improving Emergency Department Management of Adults With Sickle Cell Disease

RESULT (REflux Surgery in Lung Transplantation) Preliminary Study Protocol

Prospective Case-Series of Ligasure Advance Pistol Grip and LigaSure Blunt Tip

Right Ventricular (RV) Pacing in Early Post-operative Continuous Flow Left Ventricular Assist Device (LVAD)

Dose-varied Evaluation of Ablavar-enhanced MR Angiography of the Central Veins of the Chest in Healthy Participants

Meclizine as a Potential Smoking Cessation Treatment

Suppressive Therapy With Oral Antibiotics for Prevention of Postoperative Urinary Tract Infection (UTI)

Study Of Abraxane® And Carboplatin As First-Line Treatment For Triple Negative Metastatic Breast Cancer

Patient and Provider Interventions for Managing Osteoarthritis in Primary Care

Feasibility of a Stigma Reduction Intervention for Human Immunodeficiency Virus (HIV)-Infected Women

Mechanistic Evaluations of Pre-Cessation Therapies for Smoking Cessation

Milnacipran and Neurocognition, Pain and Fatigue in Fibromyalgia : A 13-week Randomized, Placebo Controlled Cross Over Trial

Treatment of Sickle Cell Patients Hospitalized in Pain Crisis With Prophylactic Dose Low-molecular-weight Heparin (LMWH) Versus Placebo

Statin Therapy to Improve Medication Adherence

Cross-over Study of Armodafinil Treatment of Daytime Sleepiness Associated With Treated Nocturia

Mindfulness-based Personalized Health Planning for Reducing Risk of Heart Disease and Diabetes

Trial To Evaluate the Efficacy of Intravenous Iron in Older Adults With Unexplained Anemia

Sildenafil in Single Ventricle Patients

Mila Blooms Intervention Study

Cognitive Behavioral Treatments for Depression in Chronic Illness

A Novel Optical Spectral Imaging System for Imaging Breast Tumor Margins

Gliadel, XRT, Temodar, Avastin Followed by Avastin, Temodar for Newly Diagnosed Glioblastoma Multiforme (GBM)

Concurrent Bupropion / Varenicline for Smoking Cessation

Patient Positioning in Lumbar Fusion Surgery and Its Impact on Spinal Sagittal Balance and Surgeon Satisfaction

Treatment Algorithm to Reduce the Use of Vancomycin in Adults With Blood Stream Infection

Impact of Blood Storage Duration on Physiologic Measures

Steps to Health: Targeting Obesity in the Health Care Workplace

Ehealth: Second Life Impacts Diabetes Education & Self-Management

Pacing Affects Cardiovascular Endpoints in Patients With Right Bundle-Branch Block (The PACE-RBBB Trial)

Open Label Use Of RiaStap During Aortic Reconstruction

Personalized Cardiovascular Risk Information to Initiate and Maintain Health Behavior Changes

The Effects of Respiratory Muscle Strength Training (RMST) on Inspiratory and Expiratory Muscle Strength in Adults and Children With Pompe Disease

Early Intervention for Morbidly Obese Patients After Roux-en-Y Gastric Bypass (RYGB) Surgery

Educational Videos to Improve Patient Decision Making and Race Disparities in Implantable Cardioverter Defibrillator Use

Cell Phone Intervention in Young Adults

Intervention Study of Communication in Oncologist-Patient Encounters

Open-label Milnacipran for Persistent Knee Pain One Year After Total Knee Arthroplasty (TKA)

Cognitive Remediation in 22q11DS

Reduced Radiation in Patients With Diffuse Large B-cell Lymphoma

Stress Reduction Training to Improve Sleep Quality, Stress Physiology & Cardiovascular Disease (CVD) Risk Markers

Phase II Study of Afinitor vs. Sutent in Patients With Metastatic Non-Clear Cell Renal Cell Carcinoma

Esmolol for Treatment of Perioperative Tachycardia

Phase Distribution

Therapeutic Areas

What is open in the Duke University pipeline

Duke University: open-pipeline peers nationwide

Sponsors near 1,725 trials (± recruiting share)

Sponsors near 11% open enrollment (± trial volume)

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