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NCT01727440 · ClinicalTrials.gov registry record
Identifying the Genetic Predictors of Severe Acne Vulgaris and the Outcome of Oral Isotretinoin Treatment
A clinical trial, sponsored by Duke University.
- Completed
- Registry status
- 123
- Enrollment target
NCT01727440: Completed study, sponsored by Duke University.
NCT01727440 is a clinical trial that has completed, run by Duke University. The registered enrollment target is 123 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01727440 has completed, sponsored by Duke University.
- COMPLETED
- Registry status
- 123 participants
- Enrollment target
Study Summary
The goal of this study is to enroll 250 participants that have joined the MURDOCK Study Horizon 1.5 (Duke IRB Pro00011196) with a current or prior diagnosis of severe acne AND current or prior treatment with oral isotretinoin. All 250 participants will answer a 5-page questionnaire designed to collect information on the diagnosis of severe acne and response to oral isotretinoin treatment. The aim is to identify genetic predictors of severe acne vulgaris and the outcome of oral isotretinoin treatment.
Primary Outcome
All 250 patients with severe acne will be genotyped using the Illumina 610 BeadChip. Whole-exome sequencing will be performed on 100 extremely severe acne vulgaris patients, selected based on severity and response to oral isotretinoin treatment. A case-control GWAS analysis will be performed (250 recruited patients vs. 1000 normal controls of convenience available in other studies at CHGV). Additionally, an association analyses will be conducted using complete exome sequencing data for the most
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 123 participants |
| Start Date | 2011-09 |
| Est. Completion | 2015-08 |
What the finished NCT01727440 record still lists
NCT01727440 is an observational study that tracks outcomes without assigning an intervention. The registered 123 participants enrollment target is mid-sized for trials with a published cap.
The record links to 0 conditions, and to 0 interventions.
NCT01727440 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT01727440 about?
NCT01727440 is a clinical study titled "Identifying the Genetic Predictors of Severe Acne Vulgaris and the Outcome of Oral Isotretinoin Treatment". The goal of this study is to enroll 250 participants that have joined the MURDOCK Study Horizon 1.5 (Duke IRB Pro00011196) with a current or prior diagnosis of severe acne AND current or prior treatment with oral isotretinoin. All 250 participants will answer a 5-page questionnaire designed to colle...
What is the current status of trial NCT01727440?
This trial is currently completed. The enrollment target is 123 participants. The study started on 2011-09. Estimated completion is 2015-08.
Who is sponsoring clinical trial NCT01727440?
This trial is sponsored by Duke University, which has 1,725 total clinical trials registered on ClinicalTrials.gov.
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