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NCT01780389 · ClinicalTrials.gov registry record · Phase 4
Open-label Milnacipran for Persistent Knee Pain One Year After Total Knee Arthroplasty (TKA)
A Phase 4 study of Knee Pain After Total Knee Arthroplasty and Osteoarthritis Pain, sponsored by Duke University.
- Completed
- Registry status
- Phase 4
- Development phase
- 5
- Enrollment target
- 1
- Study location
NCT01780389: Completed Phase 4 study of Knee Pain After Total Knee Arthroplasty and Osteoarthritis Pain, sponsored by Duke University.
NCT01780389 is a Phase 4 study of Knee Pain After Total Knee Arthroplasty and Osteoarthritis Pain that has completed, run by Duke University. The registered enrollment target is 5 participants, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (99% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01780389, a Phase 4 study of Knee Pain After Total Knee Arthroplasty and Osteoarthritis Pain, has completed, sponsored by Duke University.
- COMPLETED
- Registry status
- Phase 4
- Development phase
- 5 participants
- Enrollment target
- 1
- Study location
Study Summary
The current study examines the effects of milnacipran in patients who have chronic persistent knee pain one year or longer after total knee arthroplasty (TKA) to evaluate for a pain-relieving effect.
Primary Outcome
The primary outcome is change in pain VAS from baseline to 12 weeks (baseline score minus 12 week or endpoint score; positive number reflects reduction in pain score). The effect size was calculated using the VAS scores measured on a scale of 0 to 100 mm: 0= absence of pain or no pain noted 100 = worst imaginable pain/as bad as can be The higher the score the greater the over all pain intensity.
Conditions Studied
Interventions
- DRUG Open-label flexibly dosed milnacipran
Study Locations (1)
North Carolina
- Duke University Medical Center - Durham
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 5 participants |
| Start Date | 2010-10 |
| Est. Completion | 2011-07 |
| Phase | Phase 4 |
What the finished NCT01780389 record still lists
NCT01780389 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 5 participants, a relatively small participant target, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (99% lower).
The record links to 2 conditions, with Knee Pain After Total Knee Arthroplasty appearing as the primary indexed condition, and to 1 intervention - of which Open-label flexibly dosed milnacipran is the first listed.
NCT01780389 reports a single indexed study location in North Carolina.
Frequently Asked Questions
What is clinical trial NCT01780389 about?
NCT01780389 is a clinical study titled "Open-label Milnacipran for Persistent Knee Pain One Year After Total Knee Arthroplasty (TKA)". The current study examines the effects of milnacipran in patients who have chronic persistent knee pain one year or longer after total knee arthroplasty (TKA) to evaluate for a pain-relieving effect.
What is the current status of trial NCT01780389?
This trial is currently completed. It is a Phase 4 study. The enrollment target is 5 participants. The study started on 2010-10. Estimated completion is 2011-07.
What conditions does trial NCT01780389 study?
This clinical trial studies the following conditions: Knee Pain After Total Knee Arthroplasty, Osteoarthritis Pain.
What interventions are being tested in trial NCT01780389?
The interventions under investigation include: Open-label flexibly dosed milnacipran (DRUG).
Who is sponsoring clinical trial NCT01780389?
This trial is sponsored by Duke University, which has 1,725 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT01780389 being conducted?
This trial has 1 study location across North Carolina. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT01780389's enrollment target sits among peer trials
5 1989th of 2000 higher than 7 of 2,000 other Phase 4 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 4 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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