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NCT02235077 · ClinicalTrials.gov registry record · Phase 2
Study of High-dose Spironolactone vs. Placebo Therapy in Acute Heart Failure
A Phase 2 study, sponsored by Duke University.
- Completed
- Registry status
- Phase 2
- Development phase
- 360
- Enrollment target
NCT02235077: Completed Phase 2 study, sponsored by Duke University.
NCT02235077 is a Phase 2 study that has completed, run by Duke University. The registered enrollment target is 360 participants, above the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (171% higher). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02235077, a Phase 2 study, has completed, sponsored by Duke University.
- COMPLETED
- Registry status
- Phase 2
- Development phase
- 360 participants
- Enrollment target
Study Summary
The primary objective of this study is to test the hypothesis that high-dose spironolactone will lead to greater proportional reduction in NT-proBNP levels from randomization to 96 hours over standard of care.
Primary Outcome
The Core Laboratory at Vermont will determine NT-proBNP levels for calculation of the endpoint from samples obtained at randomization and 96 hours respectively. NT-proBNP was converted to log scale.
Interventions
- DRUG Placebo
- DRUG Spironolactone
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 360 participants |
| Start Date | 2014-12-30 |
| Est. Completion | 2016-06-06 |
| Phase | Phase 2 |
What the finished NCT02235077 record still lists
NCT02235077 is an interventional study that assigns participants to a tested intervention. The registered 360 participants enrollment target is mid-sized for trials with a published cap, above the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (171% higher).
The record links to 0 conditions, and to 2 interventions - of which Placebo is the first listed.
NCT02235077 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT02235077 about?
NCT02235077 is a clinical study titled "Study of High-dose Spironolactone vs. Placebo Therapy in Acute Heart Failure". The primary objective of this study is to test the hypothesis that high-dose spironolactone will lead to greater proportional reduction in NT-proBNP levels from randomization to 96 hours over standard of care.
What is the current status of trial NCT02235077?
This trial is currently completed. It is a Phase 2 study. The enrollment target is 360 participants. The study started on 2014-12-30. Estimated completion is 2016-06-06.
What interventions are being tested in trial NCT02235077?
The interventions under investigation include: Placebo (DRUG), Spironolactone (DRUG).
Who is sponsoring clinical trial NCT02235077?
This trial is sponsored by Duke University, which has 1,725 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT02235077's enrollment target sits among peer trials
360 123rd of 2000 higher than 1,874 of 2,000 other Phase 2 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 2 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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