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NCT02164318 · ClinicalTrials.gov registry record · NA
Effects of Exercise and Improved Nitric Oxide Bioavailability on Arteriovenous Fistula Maturation
A NA study, sponsored by Duke University.
- Terminated
- Registry status
- NA
- Development phase
- 11
- Enrollment target
NCT02164318: Clinical Trial NA study, sponsored by Duke University.
NCT02164318 is a NA study that was terminated before completion, run by Duke University. The registered enrollment target is 11 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (99% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02164318, a NA study, was terminated before completion, sponsored by Duke University.
- TERMINATED
- Registry status
- NA
- Development phase
- 11 participants
- Enrollment target
Study Summary
This project will examine if enhancing Nitric Oxide (NO) bioavailability increases the rates of arteriovenous fistula (AVF) maturation in end stage renal disease patients requiring vascular access for hemodialysis. To enhance NO bioavailability the study team will utilize a program of forearm exercise training, application of nitroglycerin ointment or both. Goals of this study are (A) to measure if recruited subjects can tolerate the intervention protocols, and determine if dependent variable measures, including surgery outcome, and measurement of physiologic and biologic markers, can be obtained; (B) To measure subject compliance and adherence rates for each of the intervention arms and testing visits; (C) To examine which intervention or combination of interventions demonstrates the strongest preliminary effects in order to estimate power for a pivotal intent to treat trial; and (D) explore group differences in clinical vascular markers and biologic markers in vein tissue.
Primary Outcome
Use of AVF for dialysis for dialysis dependent participants, or fistula deemed mature based on physical exam in predialysis participants (diameter \>6 mm, blood flow \>600 ml by ultrasound or estimated by physical exam).
Interventions
- DRUG Nitroglycerin ointment
- OTHER Handgrip training
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 11 participants |
| Start Date | 2014-09-01 |
| Est. Completion | 2017-03-10 |
| Phase | NA |
Why NCT02164318 stopped before completion
NCT02164318 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 11 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (99% lower).
The record links to 0 conditions, and to 2 interventions - of which Nitroglycerin ointment is the first listed.
NCT02164318 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT02164318 about?
NCT02164318 is a clinical study titled "Effects of Exercise and Improved Nitric Oxide Bioavailability on Arteriovenous Fistula Maturation". This project will examine if enhancing Nitric Oxide (NO) bioavailability increases the rates of arteriovenous fistula (AVF) maturation in end stage renal disease patients requiring vascular access for hemodialysis. To enhance NO bioavailability the study team will utilize a program of forearm exerci...
What is the current status of trial NCT02164318?
This trial is currently terminated. It is a NA study. The enrollment target is 11 participants. The study started on 2014-09-01. Estimated completion is 2017-03-10.
What interventions are being tested in trial NCT02164318?
The interventions under investigation include: Nitroglycerin ointment (DRUG), Handgrip training (OTHER).
Who is sponsoring clinical trial NCT02164318?
This trial is sponsored by Duke University, which has 1,725 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT02164318's enrollment target sits among peer trials
11 1927th of 2000 higher than 74 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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