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NCT02229565 · ClinicalTrials.gov registry record
Molecular Mechanisms Underlying Prostate Cancer Disparities
A clinical trial, sponsored by Duke University.
- Completed
- Registry status
- 226
- Enrollment target
NCT02229565: Completed study, sponsored by Duke University.
NCT02229565 is a clinical trial that has completed, run by Duke University. The registered enrollment target is 226 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02229565 has completed, sponsored by Duke University.
- COMPLETED
- Registry status
- 226 participants
- Enrollment target
Study Summary
The purpose of this study is to further elucidate the molecular mechanisms underlying prostate cancer disparities. In previous work the investigators have identified a set of differentially deregulated genes in African American versus Caucasian American prostate cancer. Based on these findings, they hypothesize that they will be able to validate these targets, originally identified in the previous work conducted at The George Washington University Medical Center, in an independent Duke University Medical Center cohort of prostate cancer specimens. In addition, the investigators hypothesize that they will be able to discover novel targets in the Duke University Medical Center cohort of prostate cancer specimens because of regional differences.
Primary Outcome
Total RNA will be interrogated for mRNA expression patterns with the Affymetrix Human Exon 1.0 ST GeneChip. Microarray data will be normalized by quantile normalization with background correction. Targeted RNA sequencing of the previously identified genetic factors specific to African American prostate cancer will confirm altered expression and alternative splicing in these deregulated genes. The Agilent Technologies SureSelect RNA Custom Capture Kit will capture and sequence transcripts. Epigen
Interventions
- DEVICE Biopsy or prostatectomy
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 226 participants |
| Start Date | 2014-11 |
| Est. Completion | 2019-10-14 |
What the finished NCT02229565 record still lists
NCT02229565 is an observational study that tracks outcomes without assigning an intervention. The registered 226 participants enrollment target is mid-sized for trials with a published cap.
The record links to 0 conditions, and to 1 intervention - of which Biopsy or prostatectomy is the first listed.
NCT02229565 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT02229565 about?
NCT02229565 is a clinical study titled "Molecular Mechanisms Underlying Prostate Cancer Disparities". The purpose of this study is to further elucidate the molecular mechanisms underlying prostate cancer disparities. In previous work the investigators have identified a set of differentially deregulated genes in African American versus Caucasian American prostate cancer. Based on these findings, they...
What is the current status of trial NCT02229565?
This trial is currently completed. The enrollment target is 226 participants. The study started on 2014-11. Estimated completion is 2019-10-14.
What interventions are being tested in trial NCT02229565?
The interventions under investigation include: Biopsy or prostatectomy (DEVICE).
Who is sponsoring clinical trial NCT02229565?
This trial is sponsored by Duke University, which has 1,725 total clinical trials registered on ClinicalTrials.gov.
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