Amgen
Amgen sponsors 558 registered US clinical trials on ClinicalTrials.gov, 55 of them currently recruiting, and 373 completed. 212 of these trials are in Phase 3-4 (later-stage) and 327 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Obesity, with 8 trials.
Trial Pipeline
558 total, page 9 of 12
Monoclonal Antibody Against PCSK9 to Reduce Elevated LDL-C in Subjects Currently Not Receiving Drug Therapy for Easing Lipid Levels-2
NCT01763827
Effect of Patient Education on Reported Bone Pain in Breast Cancer Patients Receiving Chemotherapy and Pegfilgrastim
NCT01752907
LDL-C Assessment With PCSK9 Monoclonal Antibody Inhibition Combined With Statin Therapy-2
NCT01763866
Safety/Effectiveness Study of Cysteamine Bitartrate Delayed-release Capsules (RP103) in Cysteamine Treatment Naive Patients With Cystinosis
NCT01744782
Abrilumab (AMG 181) in Adults With Moderate to Severe Crohn's Disease
NCT01696396
Abrilumab (AMG 181) in Adults With Moderate to Severe Ulcerative Colitis
NCT01694485
Safety and Efficacy Study to Evaluate Denosumab Compared With Zoledronic Acid in Postmenopausal Women With Osteoporosis
NCT01732770
NOLAN: Naproxen or Loratadine and Neulasta
NCT01712009
Investigate Effect of AMG 151 on 24-hour Ambulatory Blood Pressure & Glucose Levels in Type 2 Diabetes Mellitus Subjects
NCT01755442
Osteonecrosis of the Jaw (ONJ) Case Registry
NCT01666106
Phase 3b Safety and Efficacy Study of Apremilast to Treat Moderate to Severe Plaque-plaque Psoriasis
NCT01690299
First-Line Treatment for Locally Advanced or Metastatic Mesenchymal Epithelial Transition Factor (MET) - Positive Gastric, Lower Esophageal, or Gastroesophageal Junction (GEJ) Adenocarcinoma
NCT01697072
Evaluation of the Conversion From Peginesatide to Epoetin Alfa in Patients Receiving Hemodialysis
NCT01737879
Phase 1b/2 Trial of AMG386 With Pemetrexed and Carboplatin in Non-Small Cell Lung Cancer
NCT01666977
Strategies Using Darbepoetin Alfa to Avoid Transfusions in Chronic Kidney Disease
NCT01652872
A Study of Weekly Carfilzomib in Combination With Dexamethasone for Progressive Multiple Myeloma
NCT01677858
AMG 386 Drug-Drug Interaction Study With Paclitaxel
NCT01992341
Safety & Tolerability of Cinacalcet in Pediatric Patients With Chronic Kidney Disease and Secondary Hyperparathyroidism
NCT01439867
Phase 3 Study With Carfilzomib and Dexamethasone Versus Bortezomib and Dexamethasone for Relapsed Multiple Myeloma Patients
NCT01568866
Trial Assessing Long Term USe of PCSK9 Inhibition in Subjects With Genetic LDL Disorders
NCT01624142
Safety Study of AMG 557 in Subjects With Lupus Arthritis
NCT01683695
Denosumab Compared to Zoledronic Acid in the Treatment of Bone Disease in Patients With Multiple Myeloma
NCT01345019
Study to Determine the Efficacy and Safety of Romosozumab in the Treatment of Postmenopausal Women With Osteoporosis
NCT01631214
Study of Apremilast to Treat Subjects With Active Ankylosing Spondylitis
NCT01583374
20110165: Study to Evaluate the Effect of AMG 747 on Schizophrenia Negative Symptoms (Study 165)
NCT01568229
20101299: Study to Evaluate the Effect of AMG 747 on Schizophrenia Negative Symptoms
NCT01568216
Trial Evaluating PCSK9 Antibody in Subjects With LDL Receptor Abnormalities
NCT01588496
A Safety Study of VIMOVO in Adolescents With Juvenile Idiopathic Arthritis (JIA)
NCT01544114
Open-label Safety and Pharmacokinetic Study of DUEXIS® (Ibuprofen and Famotidine) Tablets in Juvenile Idiopathic Arthritis
NCT01563185
Transition From Alendronate to Romosozumab (AMG 785)
NCT01588509
Efficacy and Safety of Denosumab Compared With Risedronate in Individuals Taking Glucocorticoids
NCT01575873
Efficacy and Safety of Romosozumab Treatment in Postmenopausal Women With Osteoporosis
NCT01575834
A Drug-Drug Interaction Study to Evaluate the Effect of Rifampin on the Pharmacokinetics of Apremilast
NCT01561963
Effect of Food on the Pharmacokinetics of Apremilast (CC-10004) in Healthy Adults
NCT01634178
Effects of Age and Sex on the Pharmacokinetics of Apremilast in Healthy Adults
NCT01634191
Etanercept Treatment in Patients With Moderate to Severe Plaque Psoriasis Who Lost Response to Adalimumab
NCT01543204
AMG 595 First-in-Human in Recurrent Gliomas
NCT01475006
Durable Effect of PCSK9 Antibody CompARed wiTh placEbo Study
NCT01516879
Safety and Efficacy Study of Romiplostim to Treat Immune Thrombocytopenia (ITP) in Pediatric Patients
NCT01444417
AMG 172 First in Human Study in Patients With Kidney Cancer
NCT01497821
TRINOVA-3: A Study of AMG 386 or AMG 386 Placebo in Combination With Paclitaxel and Carboplatin to Treat Ovarian Cancer
NCT01493505
AMG 761 in Adults With Asthma
NCT01514981
Multiple Dose Study to Evaluate the Safety of Multiple Doses of Denosumab 120 mg in Adults With Severe Chronic Kidney Disease (CKD) and CKD on Dialysis
NCT01464931
Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Clinical Effects of AMG 557 in Adults With Psoriasis
NCT01493518
Single Ascending Dose Trial in Patients With Type 2 Diabetes
NCT01492465
Open-label Study of the Safety and Activity of Oprozomib in Patients With Hematologic Malignancies
NCT01416428
Open Label Study of Long Term Evaluation Against LDL-C Trial
NCT01439880
Study Evaluating Orally Administered AMG 900 in Adult Subjects With Acute Myeloid Leukemia
NCT01380756
Safety Study of AMG 557 in Subjects With Subacute Cutaneous Lupus Erythematosus
NCT01389895
A Pharmacokinetic Study of AMG 386 in Cancer Subjects With Normal and Impaired Renal Function
NCT01331941
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 216 |
| Phase 2 | 111 |
| Phase 3 | 174 |
| Phase 4 | 38 |
What the Pipeline for Amgen Shows
According to the ClinicalTrials.gov registry, Amgen is linked to 558 US clinical trials across every stage of research activity. Of those, 55 studies are currently recruiting, about 10% of the sponsor's indexed portfolio, and 373 are already marked complete, representing roughly 67% of the total.
The phase mix for Amgen reports 212 late-stage studies (Phase 3 and Phase 4 combined) and 327 earlier-phase studies (Phase 1 and Phase 2).
The top therapeutic focus area indexed for Amgen is Obesity with 8 linked trials, and 9 other condition areas appear in the top list above.
How to read these pipeline numbers
Recruiting share is one of the more practical signals here: it reflects how much of a sponsor's research is presently open to new participants, while the completed share indicates the depth of finished work that has already contributed registry results. Both counts come directly from the public ClinicalTrials.gov dataset and are refreshed on the registry side; this page mirrors the latest data pull without altering it.
A portfolio weighted toward Phase 3 usually reflects an organization advancing candidates toward regulatory review, where the research centers on comparative efficacy and broader safety across larger populations. A heavier Phase 1 and Phase 2 tilt generally indicates exploratory work, safety, dosing, and early signal detection, and is common among research-forward sponsors that seed many early programs. Phase 4 entries, when present, track interventions already in real-world use and typically focus on long-term safety, effectiveness across subgroups, or formulation comparisons.
That distribution is a quick read of where the organization concentrates its research attention; it does not imply product availability, market share, or any clinical endorsement. All numbers on this page come from ClinicalTrials.gov maintained by the National Library of Medicine, and counts can shift as new studies are registered or existing ones update their status. This information is provided for reference and educational purposes only, not as medical, investment, or regulatory advice, verify current details directly with ClinicalTrials.gov before relying on any figure here.
Read our methodology - how this data is sourced, computed, and verified.
Related
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial from this sponsor, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.