Amgen
Amgen sponsors 558 registered US clinical trials on ClinicalTrials.gov, 55 of them currently recruiting, and 373 completed. 212 of these trials are in Phase 3-4 (later-stage) and 327 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Obesity, with 8 trials.
Trial Pipeline
558 total, page 10 of 12
AMG 151 Amgen Protocol Number 20100761
NCT01464437
First-in-Human Study to Evaluate AMG 579 in Healthy Subjects and Patients With Stable Schizophrenia
NCT01568203
Goal Achievement After Utilizing an Anti-PCSK9 Antibody in Statin Intolerant Subjects
NCT01375764
Persistence With Prolia® (Denosumab) in Postmenopausal Women With Osteoporosis
NCT02732210
Monoclonal Antibody Against PCSK9 to Reduce Elevated Low-density Lipoprotein Cholesterol (LDL-C) in Adults Currently Not Receiving Drug Therapy for Easing Lipid Levels
NCT01375777
LAPLACE-TIMI 57: Low-density Lipoprotein Cholesterol (LDL-C) Assessment With PCSK9 monoclonaL Antibody Inhibition Combined With Statin thErapy
NCT01380730
Study of the Safety, Pharmacokinetics and Efficacy of HPN-100, in Pediatric Subjects With Urea Cycle Disorders (UCDs)
NCT01347073
Pediatric Chronic Kidney Disease Safety and Efficacy
NCT01277510
AMG 386 (Trebananib) in Ovarian Cancer (TRINOVA-2)
NCT01281254
AMG 319 Lymphoid Malignancy FIH
NCT01300026
Open Label Extension Study of Conatumumab and Ganitumab (AMG 479)
NCT01327612
Moderate Rheumatoid Arthritis (RA) With Etanercept (Enbrel)
NCT01313208
Effects of Denosumab on the Pharmacokinetics of Etanercept
NCT01294397
Long-term Safety Study of Brodalumab in Adults With Crohn's Disease
NCT01199302
Study to Evaluate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of AMG 181.
NCT01290042
Study to Evaluate Cinacalcet in Children With Chronic Kidney Disease
NCT01290029
Trial of Aeroquin Versus Tobramycin Inhalation Solution (TIS) in Cystic Fibrosis (CF) Patients
NCT01270347
Efficacy and Safety Study of Apremilast to Treat Active Psoriatic Arthritis (PsA)
NCT01307423
Study of Apremilast to Evaluate the Safety and Effectiveness for Patients With Rheumatoid Arthritis
NCT01285310
A Study of AMG 337 in Subjects With Advanced Solid Tumors
NCT01253707
Interventional Study in Adults With Immune Thrombocytopenia Purpura (ITP) Receiving Romiplostim
NCT01143038
Study to Evaluate Safety and Effectiveness of Oral Apremilast (CC-10004) in Patients With Moderate to Severe Plaque Psoriasis.
NCT01232283
Brodalumab (AMG 827) in Adults With Moderate to Severe Crohn's Disease
NCT01150890
MP-376 (Aeroquin™, Levofloxacin for Inhalation) in Patients With Cystic Fibrosis
NCT01180634
TRINOVA-1: A Study of AMG 386 or Placebo, in Combination With Weekly Paclitaxel Chemotherapy, as Treatment for Ovarian Cancer, Primary Peritoneal Cancer and Fallopian Tube Cancer
NCT01204749
A Study to Evaluate the Dosing of AMG 827 for Subjects With Inadequately Controlled Asthma
NCT01199289
To Evaluate the Safety of Long-term Use of HPN-100 in the Management of Urea Cycle Disorders (UCDs)
NCT01257737
To Evaluate the Preliminary Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Efficacy of CC-11050 in Subjects With Discoid Lupus Erythematosus and Subacute Cutaneous Lupus Erythematosus
NCT01300208
PALACE 3: Efficacy and Safety Study of Apremilast to Treat Active Psoriatic Arthritis
NCT01212770
PALACE 2: Efficacy and Safety Study of Apremilast to Treat Active Psoriatic Arthritis
NCT01212757
Long-Term Safety Follow-up Study of Cysteamine Bitartrate Delayed-release Capsules (RP103)
NCT01197378
Safety Study of AMG 811 in Subjects With Discoid Lupus Erythematosus
NCT01164917
Study Comparing Carfilzomib, Lenalidomide, and Dexamethasone (CRd) vs Lenalidomide and Dexamethasone (Rd) in Subjects With Relapsed Multiple Myeloma
NCT01080391
Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of AMG 181 in Healthy Subjects and Subjects With Mild to Moderate Ulcerative Colitis
NCT01164904
Study To Assess FRacTure Healing With SclerosTin Antibody - Hip
NCT01081678
Safety and Efficacy of AMG 827 in Subjects With RA
NCT01059448
Efficacy and Safety Study of Apremilast to Treat Active Psoriatic Arthritis
NCT01172938
Study of Denosumab as Adjuvant Treatment for Women With High Risk Early Breast Cancer Receiving Neoadjuvant or Adjuvant Therapy (D-CARE)
NCT01077154
Phase 3 Study of Cysteamine Bitartrate Delayed-release (RP103) Compared to Cystagon® in Patients With Cystinosis
NCT01000961
Study to Evaluate the Prospective Payment System
NCT01717989
A Phase 1 Dose Escalation Study of AMG 780 in Adult Subjects With Advanced Solid Tumors
NCT01137552
Double-Blind Randomized Crossover Trial to Access Electrocardiogram Effects of HPN-100
NCT01135680
Registry Study for Talimogene Laherparepvec
NCT02173171
Phase 1 Study of Oprozomib Administered Orally in Patients With Advanced Refractory or Recurrent Solid Tumors
NCT01129349
Efficacy and Safety Study of Cinacalcet for the Treatment of Hypercalcemia in Patients With Primary Hyperparathyroidism Unable to Undergo Parathyroidectomy
NCT00975221
Study of the Safety and Tolerability of HPN-100 Compared to Sodium Phenylbutyrate in Children With Urea Cycle Disorders
NCT00947544
ASPECCT: A Study of Panitumumab Efficacy and Safety Compared to Cetuximab in Patients With KRAS Wild-Type Metastatic Colorectal Cancer
NCT01001377
A Study Evaluating the Safety and Efficacy of Long-term Dosing of Romiplostim in Thrombocytopenic Pediatric Patients With Immune (Idiopathic) Thrombocytopenia Purpura
NCT01071954
Treatment of Autonomous Hyperparathyroidism in Post Renal Transplant Recipients
NCT00975000
A Study of Safety and Efficacy of HPN-100 in Subjects With Cirrhosis and Episodic Hepatic Encephalopathy
NCT00999167
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 216 |
| Phase 2 | 111 |
| Phase 3 | 174 |
| Phase 4 | 38 |
What the Pipeline for Amgen Shows
According to the ClinicalTrials.gov registry, Amgen is linked to 558 US clinical trials across every stage of research activity. Of those, 55 studies are currently recruiting, about 10% of the sponsor's indexed portfolio, and 373 are already marked complete, representing roughly 67% of the total.
The phase mix for Amgen reports 212 late-stage studies (Phase 3 and Phase 4 combined) and 327 earlier-phase studies (Phase 1 and Phase 2).
The top therapeutic focus area indexed for Amgen is Obesity with 8 linked trials, and 9 other condition areas appear in the top list above.
How to read these pipeline numbers
Recruiting share is one of the more practical signals here: it reflects how much of a sponsor's research is presently open to new participants, while the completed share indicates the depth of finished work that has already contributed registry results. Both counts come directly from the public ClinicalTrials.gov dataset and are refreshed on the registry side; this page mirrors the latest data pull without altering it.
A portfolio weighted toward Phase 3 usually reflects an organization advancing candidates toward regulatory review, where the research centers on comparative efficacy and broader safety across larger populations. A heavier Phase 1 and Phase 2 tilt generally indicates exploratory work, safety, dosing, and early signal detection, and is common among research-forward sponsors that seed many early programs. Phase 4 entries, when present, track interventions already in real-world use and typically focus on long-term safety, effectiveness across subgroups, or formulation comparisons.
That distribution is a quick read of where the organization concentrates its research attention; it does not imply product availability, market share, or any clinical endorsement. All numbers on this page come from ClinicalTrials.gov maintained by the National Library of Medicine, and counts can shift as new studies are registered or existing ones update their status. This information is provided for reference and educational purposes only, not as medical, investment, or regulatory advice, verify current details directly with ClinicalTrials.gov before relying on any figure here.
Read our methodology - how this data is sourced, computed, and verified.
Related
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial from this sponsor, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.